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Tismazol (Metronidazole)

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Tismazol is a medicine used to treat different types of bacterial and parasitic infections, including those that affect the skin, vagina, blood, heart, bone, stomach, liver, joints, nervous system, respiratory tract, and other areas of the body.

Other names for this medication:
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Also known as: Metronidazole


Tismazol (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Tismazol is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.


The usual adult oral dosage is 7.5 mg/kg every six hours (approx. 500 mg for a 70-kg adult). A maximum of 4 g should not be exceeded during a 24-hour period.

The usual duration of therapy is 7 to 10 days; however, infections of the bone and joint, lower respiratory tract, and endocardium may require longer treatment.

Patients with severe hepatic disease metabolize metronidazole slowly, with resultant accumulation.


Single oral doses of Tismazol, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Tismazol has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Tismazol overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.


Store Tismazol at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Tismazol out of the reach of children and away from pets.

Side effects

The most common side effects associated with Tismazol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Psychotic Reaction with Disulfiram. Use of oral metronidazole is associated with psychotic reactions in alcoholic patients who were using disulfiram concurrently. Do not administer metronidazole to patients who have taken disulfiram within the last two weeks.

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All of the metal salts with known carcinogenic potential in animals or mutagenic activity in microbial or mammalian cells increased the SA7 transformation frequency. Hemoptysis can be a life-threatening condition that warrants urgent investigation and intervention. The potential of this technique to increase oral absorption and hence bioavailability is enormous. NHA-1 MAb given intraperitoneally (i.p.) 1 day before virus infection induced early death by about 2 days in comparison to controls, whereas mice administered HAI-positive anti-gpE JEV specific MAbs (Hs-1 or Hs-4) were invariably protected. Anteriorly based palatal flap for closure of large oroantral fistula. A Unified Semantic Framework for the description of assistive technologies. Many hemopoietic cell lines were examined for their ability to adhere to culture dishes coated with extracellular matrix proteins. Evaluation of RA disease activity is therefore important to predict the outcome and effectiveness of therapeutic interventions during follow-up. A qualitative framework was used based on an appreciative inquiry approach to gather perceptions and experiences of 31 participants at the 2014 Social Media Summit.

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In order to maintain high levels of ACS it is important to understand correlates of ACS in this population. Scab removal is a time-consuming process and often injures the skin at a buttonhole entry site. These studies showed an aberrant microRNA expression profile that distinguishes unequivocally among PTC, ATC, and normal thyroid tissue. These should include histological changes in parenchymal tissue, altered integrity of the alveolar capillary barrier, inflammation, and abnormal pulmonary function. Effects of high frequency oscillatory ventilation and its combination with pulmonary surfactant treatment on inflammatory response in rabbit lung with inhalation injury. Microwave plasma atomic emission spectrometric determination of Ca, K and Mg in various cheese varieties. We infer that this type of therapy does not oeprate on the level of platelet destroying cells but rather affects antibody producing cells.

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A quantitative approach to assessing the efficacy of occupant protection programs: A case study from Montana. Our findings demonstrate for the first time that L-carnitine protects HCECs from oxidative stress by lessening the declines in antioxidant enzymes and suppressing ROS production. Inhibition of N-linked oligosaccharide trimming mannosidases blocks human B cell development. Outcomes were compared in black, white, Asian, and Hispanic women. Here, we showed that medial orbitofrontal cortex lesion prevents d-cycloserine enhancement of fear extinction. The sulci were injected by three different methods (aluminium wire, red lead and thick barium). Comparison of domperidone, droperidol, and metoclopramide in the prevention and treatment of nausea and vomiting after balanced general anesthesia. However, gross hematuria recurred, and the patient underwent left nephroureterectomy.

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Preparation and characterization of laser cladding wollastonite derived bioceramic coating on titanium alloy. The predictive ability of quantitative computed tomography, dual energy x-ray absorptiometry, insertional torque, in situ stiffness, and pedicular geometry was assessed using multiple regression. Despite its importance, in clinical practice the routine measurement of CBF is uncommon, as changes in CBF can occur abruptly. Biomolecules in the m/z range from 700 to 900 were more effectively detected in the freeze-cracked than from simple frozen adult nematode bodies. Such a relationship may become a novel therapeutic target to prevent this arrhythmia or decrease the frequency of paroxysms. This paper describes the interaction between testosterone and photoperiod in the regulation of beta-endorphin levels in three regions of the hypothalamus.

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A robotic home telehealth platform system for treatment adherence, social assistance and companionship - an overview. An electronic circuit amplifies the retrieved light signal and the output voltage is used to classify the forces on the tip. Transesophageal echocardiography for definition of incidence and monitoring removal by improved techniques. Psychological disorders and their correlates in an Australian community sample of preadolescent children. With combining the quantitative structure-property relationship between the molecule properties calculated by the computational chemistry methods and the thermodynamic properties obtained from experiments, researchers can precisely predict the next-generation of extracting agents and novel extraction processes. A possible explanation for the increased sensitivity following endotoxin injection is that it apparently results from an increased concentration of endotoxin in the blood due to the impossibility of removing the endotoxin via the kidneys. Uterine lipoleiomyomas are often diagnosed preoperatively as uterine myomas or ovarian mature teratomas.

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Even in the group with combined lesions, microdysgenesis was interpreted as being embryofetal. Five years later the stump became painful and swelled with dramatic rapidity. Comparison of the syncytium forming ability of the Vladivostok and Japanese variants of virus and some other factors related to this phenomenon. We compared rates of SIB exhibited by a 32-year-old woman diagnosed with profound retardation across conditions in which access to restraint was (a) continuously available, (b) presented as a consequence for SIB, or (c) unavailable. This study was designed to investigate the antinociceptive effects of one of the most prescribed benzodiazepines (BZ) -i.e., alprazolam.

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A detailed spectroscopic investigation based on UV, IR, high-resolution mass spectrometry, and 2D 1H and 13C nuclear magnetic resonance revealed that the former zithromax antibiotic zithromax was indole-2,3-dione (isatin). The Salmonella/microsome assay is the most used mutagenicity test and can identify the major chemical classes responsible for observed mutagenicity. Therapeutic experiences with fluocinolone acetonide in combination with long-term occlussive bandages. Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450. In both cases the surgical procedure with mitral commissurotomy and transplant of the anomalous pulmonary veins to the left atrium was successful. Three-Dimensional Echocardiography: A Powerful New Tool in the Evaluation of Mitral Annular Structure and Dynamics. The point mutation resulted in an asparagine to aspartic acid substitution 60 amino acids from the predicted C-terminus.

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The inhibition of the binding of 3H-dpTpA to the antibodies by various nonradioactive mono- and oligonucleotides showed that the antibodies were sequence specific and recognized the whole molecule of dpTpA. Each array sensor element is a 1.8-mm-long spiral waveguide folded within a 130 microm diameter spot and is incorporated in a balanced Mach-Zehnder interferometer with a near temperature independent response. Osteogenesis and neurogenesis: a robust link also for language evolution. Boron-hyaluronic acid (BHA) was tested for its feasibility as a potential agent for BNCT. Long-term outcomes after surgical ventricular restoration and coronary artery bypass grafting in patients with postinfarction left ventricular anterior aneurysm. However, the advent of anti-vascular endothelial growth factor (anti-VEGF) has revolutionized the treatment of DME. The events leading up to and the sequelae from a drowning incident levaquin pseudomonas dosing vary greatly based on numerous factors, but the primary physiologic insult is always hypoxia. Toll-like receptors (TLRs) have evolved as key molecules in innate and adaptive immunity. Chambers with the platelet concentrate showed a significant increase in bone and total tissue ingrowth distance compared to untreated controls, indicating a platelet concentrate might enhance the clinical performance of porous hydroxyapatite in bone replacement. Several monoclonal anti-human tumor antibodies were assayed for binding to a number of human tumor lines and for the ability to promote specific tumor cell lysis when cross-linked with anti-T3.

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Hepatotoxicity of sodium valproate in ornithine transcarbamylase-deficient mice. Liver hemorrhages were observed in laying hens but not in Japanese quail. Suggestions are made for how to close this gap, including ways to increase understanding of behavioral issues, opportunities for funding of key research and implementation questions, and how behavioral science principles can become more integrated into diabetes organizations and care. Fibers of RecA protein and complexes of RecA protein and single-stranded cipro medication cost phi X174 DNA as visualized by negative-stain electron microscopy. Like eubacteria, archaebacteria are prokaryotes, although they are phylogenetically closer to eukaryotes. Here we present a new drug delivery concept based on photochemical internalization-principle -- photochemical disruption of endocytic vesicles before delivery of macromolecules, leading to an instant endosomal release instead of detrimental stay of the molecules in endocytic vesicles. All 13 patients had fracture of the radial head and 10 patients had fracture of the coronoid process. Normal anatomy, physiology, psychology, including the role of factors in the environment. For those at risk, hepatitis E should be considered in the differential diagnosis of acute hepatitis. Thirty male SD rats were randomly divided into normal group, atherosclerosis model group and felodipine treating group.

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Comparative characteristics of pathomorphological changes caused by vaccinal strains of Brucella no. Enhancement of contraction strength by nitrate was not associated with alterations in membrane potential. In a patient, frozen sections revealed a positive surgical margin and additional resection was performed. Chi-square tests were used to compare norovirus infection status of diarrhea cases in different age groups as well as during different periods. The generation of three independent Scn8a mutations among 1100 tested G3 families demonstrates that the Scn8a locus is highly susceptible to ENU mutagenesis. The sonographic criteria for the presence of a pseudocapsule were a peritumoral hypoanechoic halo on conventional gray-scale imaging and a rim of perilesional enhancement, increasing in the tardive phase of the examination, on contrast-enhanced second-harmonic imaging. The finding may propose a possible role of the imbalance of blood lymphocyte subpopulations on the pathogenesis of pernicious anemia and also a responsibility of vitamin B12 for such a selective reduction in the OKT8-positive blood cells. The experiments on 25 dogs have shown a considerable decrease in the consumption of clotting factors and reduced hyperfibrinolysis with the onset of disseminated intravascular coagulation syndrome in animals poisoned with acetic essence (2 ml/kg). To evaluate treatment response in patients with proliferative and membranous lupus nephritis (LN) according to ACR-RRC.

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These alternative sources include stem cells, which are attractive for cell-based therapies because of their potential ease of isolation, propagation and manipulation, and their ability in some cases to migrate to areas of pathology and differentiate into specific and appropriate cell types. Disruption of the dysbindin gene dramatically increased NR2A-mediated synaptic currents, without affecting AMPA receptor currents, in hippocampal CA1 neurons. Multivariable logistic regression analysis was performed to identify factors independently associated with inconsistent condom use. Nitroglycerin (NTG) dilates capacitance veins and resistance arterioles, but its relative effects on veins and arterioles are not known. Dietary nitrate has thus been associated favorably with nitric-oxide-regulated processes including blood flow and energy metabolism. Umbilical cord plasma cotinine levels have been shown to correlate with self-reported daily number of cigarettes at the end of pregnancy, but the exact relationship between maternal noroxin generic name and newborn plasma cotinine (and nicotine) is unknown. The results of the current study indicate that MK acts as an antiapoptotic factor in HepG2 cells through the down-regulation of caspase-3 activity. Familial multiple sclerosis: volumetric assessment in clinically symptomatic and asymptomatic individuals. Knowledge of the natural history and presentation of this disease will allow its early recognition and minimize the morbidity and mortality resulting from misdiagnosis. This does not occur in neutrophils from mice with chronic granulomatous disease and may explain the formation of granuloma in this condition.

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The primary purpose of this secondary analysis was to determine whether 103 participants with chronic obstructive pulmonary disease rated the affective dimension of dyspnea (dyspnea-related anxiety and dyspnea-related distress) separately from the sensory dimension (intensity) during baseline exercise testing conducted as part of a randomized clinical trial. Percutaneous transpedicular vertebroplasty for treatment of osteoporosis-induced vertebral fractures. Reliable and rapid methods as immunofluorescence with monoclonal antibodies and reverse transcription-polymerase chain reaction allow new researches on epidemiology. The protein pattern of the chromatin is not influenced by the factor as is the phosphorylation or acetylation of nuclear proteins. In this study, we demonstrate for the first time that matsutake mushrooms from Scandinavia, Mediterranean regions, North America, and Tibet form ectomycorrhizae with Pinus densiflora similar to the Far East T. We expect that the next report will support and expand on these findings, providing continuing evidence of the value of a national endovascular registry.

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Nurses can assist patients through the diagnostic process, treatment and prevention of UTIs, promoting their wellbeing and empowerment. Comparison between the two phases and their optical behavior is made. Subjects with vestibular loss restricted upper body segment motion within the frontal and transverse planes for the 90-degree and overhead tasks. Preoperative local MRI-staging of patients with a suspected pancreatic mass. This report describes the successful use of tinidazole in 3 cases of clinically metronidazole-resistant trichomoniasis. Besides MRI, 4-dimensional CT, PET/CT, invasive-selective venous sampling, or angiography, both ultrasound and scintigraphy are standard of care for lesion localization. It finds no evidence to support health-based regulations of HPC concentrations. However, symptoms may occur years later from the migration of the foreign body. In this Account we summarize the recent progress in the computational modeling of the transition-metal-catalyzed 1,3-diene polymerization. Thus, it is critical to target stem cells when designing gene therapy regimes for genetically inherited diseases, such as epidermolysis bullosa simplex (EBS).

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The resultant static and dynamic contour deformity can be corrected by reattaching the muscle to the inferior border of the mandible. When participants made judgments about either the location or whether they liked or disliked an image, however, we observed significantly increased activation in frontal, limbic, and temporal regions in the patients relative to the controls. Pattern of ocular dominance columns in human striate cortex in strabismic amblyopia. Five healthy males, age 25-32 y, were fed in cleocin t topical gel sequence a diet of ordinary foods (10 d, PI), a low-methionine diet (285 mg/d, 14 d, PII), and an adequate-methionine diet (725 mg/d, 7 d, PIII). Stimulation of growth hormone release in vivo and in vitro by alpha-MSH. Activities of liver mixed function oxidase system in rats fed trans fat. When quantitating blood shifts in response to environmental effects, it is important to take into account the phasic pattern of certain processes. Bisphosphonates effectively correct HCM and reduce skeletal morbidity in patients with bone metastases.

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Acute exacerbation of HIV-related LIP has not been well described. CT demonstrated a new area of central hypodensity in a presumed desmoid tumor, compressing the left ureter. The expressions of COX-2 in SNU 423 and SNU 449 hepatocellular carcinoma cell lines were examined using RT-PCR and Western blot. Must critical health services research in the psychosocial area be biased?. Stress or heat-shock proteins (HSPs) are highly conserved proteins present in cells of both prokaryotes and eukaryotes, providing them with protection from cellular and environmental stress factors.Based on molecular-weight, HSPs can be divided into the large (HSP100: 100-110 kDa and HSP90: 75-96 kDa), intermediate (HSP70: 66-78 kDa, HSP60, and HSP40), and small (sHSP:8.5-40 kDa) subfamilies. Donor Action, an international initiative to alleviate organ shortage, provides a comprehensive state-of-the-art methodology that helps critical care units develop a tailor-made approach to optimize donation practices and performance. The superficial layer has a low mATPase activity after both acid and alkali pre-incubation, whereas the deeper layer has a high mATPase activity after acid and alkali pre-incubation, being more resistent to these conditions even than is the white muscle. Biochemical isolation of a membrane microdomain from resting platelets highly enriched in the plasma membrane glycoprotein CD36. The theoretical results obtained using the MSFC model yielded a highly accurate prediction of the diffusion coefficients and were in a good agreement with the VOC concentration measurements in the environmental test chamber sumycin 500 mg uses in hindi .

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