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Tetracin (Oxytetracycline)
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Tetracin

Tetracin was the second of the broad-spectrum tetracycline group of antibiotics to be discovered. Tetracin works by interfering with the ability of bacteria to produce essential proteins. Without these proteins, the bacteria cannot grow, multiply and increase in numbers.

Other names for this medication:
Betacycline, Cotet, Dynoxytet, Ecomycin, Geomicina, Innolyre, Oxyteracin, Oxytetracycline, Tetracin

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Also known as: Oxytetracycline

Description

Tetracin is primarily bacteriostatic and is thought to exert its antimicrobial effect by the inhibition of protein synthesis. Tetracin is active against a wide range of gram-negative and gram-positive organisms.

The drugs in the Tetracin class have closely similar antimicrobial spectra, and cross resistance among them is common. Microorganisms may be considered susceptible if the M.I.C. (minimum inhibitory concentration) is not more than 4.0 mcg/ml and intermediate if the M.I.C. is 4.0 to 12.5 mcg/ml.

Susceptibility plate testing: A Tetracin disc may be used to determine microbial susceptibility to drugs in the Tetracin class. If the Kirby-Bauer method of disc susceptibility testing is used, a 30 mcg Tetracin disc should give a zone of at least 19 mm when tested against a Tetracin-susceptible bacterial strain.

Tetracins are readily absorbed and are bound to plasma proteins in varying degree. They are concentrated by the liver in the bile, and excreted in the urine and feces at high concentrations and in a biologically active form.

Dosage

Adults: Usual daily dose, 1–2 g divided in four equal doses, depending on the severity of the infection.

For children above eight years of age: Usual daily dose, 10–20 mg per pound (25–50 mg/kg) of body weight divided in four equal doses.

Therapy should be continued for at least 24–48 hours after symptoms and fever have subsided.

For treatment of brucellosis, 500 mg Tetracin four times daily for 3 weeks should be accompanied by streptomycin, 1 gram intramuscularly twice daily the first week, and once daily the second week.

For treatment of uncomplicated gonorrhea, when penicillin is contraindicated, tetracycline may be used for the treatment of both males and females in the following divided dosage schedule: 1.5 grams initially followed by 0.5 gram q.i.d. for a total of 9.0 grams.

For treatment of syphilis, a total of 30–40 grams in equally divided doses over a period of 10–15 days should be given. Close follow-up, including laboratory tests, is recommended.

Administration of adequate amounts of fluid along with capsule and tablet forms of drugs in the tetracycline class is recommended to wash down the drugs and reduce the risk of esophageal irritation and ulceration.

Concomitant therapy: Antacids containing aluminum, calcium, or magnesium impair absorption and should not be given to patients taking oral tetracyclines.

Food and some dairy products also interfere with absorption. Oral forms of tetracyclines should be given 1 hour before or 2 hours after meals. Pediatric oral dosage forms should not be given with milk formulas and should be given at least 1 hour prior to feeding.

In patients with renal impairment. Total dosage should be decreased by reduction of recommended individual doses and/or by extending time intervals between doses.

In the treatment of streptococcal infections, a therapeutic dose of Tetracin should be administered for at least 10 days.

Overdose

If you overdose Generic Tetracycline and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Tetracin overdosage: retching, diarrhoea, nausea.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Tetracin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not use Tetracin if you are allergic to Tetracin components. Do not use Tetracin if you take antacids containing aluminum, calcium, or magnesium impair absorption. Do not use Tetracin if you have liver problems, kidney disease. Do not take Tetracin if you're pregnant or you plan to have a baby, or you are breastfeeding. Tetracin is not to use in children under 8 years old. Do not take Tetracin if you suffer from porphyria. Use of Tetracin in children may cause permanent discoloring of the teeth. Do not drive, operate machinery or perform other possibly unsafe tasks until you know how you react to Tetracin. Try to be careful with sunbeams. Tetracin makes skin sensitive to sunlight. Protect skin from the sun. It's not recommended to use hormonal birth control as it may not work. To prevent pregnancy, use an extra form of birth control.

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