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Terramycin (Oxytetracycline)
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Terramycin

Terramycin was the second of the broad-spectrum tetracycline group of antibiotics to be discovered. Terramycin works by interfering with the ability of bacteria to produce essential proteins. Without these proteins, the bacteria cannot grow, multiply and increase in numbers.

Other names for this medication:
Betacycline, Cotet, Dynoxytet, Ecomycin, Geomicina, Innolyre, Oxyteracin, Oxytetracycline, Tetracin

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Ilosone, Amoxil, Duricef, Sumycin, Zithromax, Myambutol, Terramycin, Keflex

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Also known as: Oxytetracycline

Description

Terramycin is primarily bacteriostatic and is thought to exert its antimicrobial effect by the inhibition of protein synthesis. Terramycin is active against a wide range of gram-negative and gram-positive organisms.

The drugs in the Terramycin class have closely similar antimicrobial spectra, and cross resistance among them is common. Microorganisms may be considered susceptible if the M.I.C. (minimum inhibitory concentration) is not more than 4.0 mcg/ml and intermediate if the M.I.C. is 4.0 to 12.5 mcg/ml.

Susceptibility plate testing: A Terramycin disc may be used to determine microbial susceptibility to drugs in the Terramycin class. If the Kirby-Bauer method of disc susceptibility testing is used, a 30 mcg Terramycin disc should give a zone of at least 19 mm when tested against a Terramycin-susceptible bacterial strain.

Terramycins are readily absorbed and are bound to plasma proteins in varying degree. They are concentrated by the liver in the bile, and excreted in the urine and feces at high concentrations and in a biologically active form.

Dosage

Take Terramycin by mouth with a full glass of water on an empty stomach at least 1 hour before or 2 hours after eating. Do not lie down for 30 minutes after taking Terramycin. Avoid taking milk, dairy products, calcium-enriched juices before and after consuming the drug. It is better to take Terramycin every day at the same time. Terramycin treats different types of bacterial infections and can be used both by adults and by children. Thus, each age has different instructions. For children above 8 years of age: the usual daily dose is 25–50 mg per kg of body weight divided into 4 equal doses. For Adults: the usual daily dose is 1–2 g divided in 4 equal doses, depending on the severity of the infection. For treatment of brucellosis, 500 mg oxytetracycline four times daily for 3 weeks should be accompanied by streptomycin, 1 gram intramuscularly twice daily the first week, and once daily the second week. For treatment of uncomplicated gonorrhea, when penicillin is contraindicated, tetracycline may be used for the treatment of both males and females in the following divided dosage schedule: 1.5 grams initially followed by 0.5 gram q.i.d. for a total of 9.0 grams. For treatment of syphilis, a total of 30–40 grams in equally divided doses over a period of 10–15 days should be given. Do not stop taking Terramycin suddenly. Therapy should be continued for at least 24–48 hours after symptoms and fever have subsided.

Overdose

If you overdose Generic Tetracycline and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Terramycin overdosage: retching, diarrhoea, nausea.

Storage

Store Terramycin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Keep away from heat, moisture, and light. Do not store in the bathroom. Keep Terramycin out of the reach of children and away from pets.

Side effects

The most common side effects associated with Terramycin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not use Terramycin if you are allergic to Terramycin components. Do not use Terramycin if you take antacids containing aluminum, calcium, or magnesium impair absorption. Do not use Terramycin if you have liver problems, kidney disease. Do not take Terramycin if you're pregnant or you plan to have a baby, or you are breastfeeding. Terramycin is not to use in children under 8 years old. Do not take Terramycin if you suffer from porphyria. Use of Terramycin in children may cause permanent discoloring of the teeth. Do not drive, operate machinery or perform other possibly unsafe tasks until you know how you react to Terramycin. Try to be careful with sunbeams. Terramycin makes skin sensitive to sunlight. Protect skin from the sun. It's not recommended to use hormonal birth control as it may not work. To prevent pregnancy, use an extra form of birth control.

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