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Synclar (Clarithromycin)
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Synclar

Synclar is used for the treatment of various infections in the body like infections of the throat, sinus, skin, soft tissue, chest (infection of lungs and windpipe). It is also used in the treatment of ulcers in the intestine caused by bacteria known as helicobacter pylori. It is also used for pneumonia as well as for skin infections.

Other names for this medication:
Clabel, Clacee, Clamycin, Clarimac, Clarimycin, Claripen, Clariston, Claritron, Claritt, Clarix, Clarocin, Clarogen, Claryl, Cleanomisin, Emimycin, Euromicina, Fromilid, Hecobac, Italclar, Kalixocin, Karid, Karin, Klabion, Klarithran, Klarithrin, Klerimed, Krobicin, Likmoss, Lyoclar, Macromicina, Onexid, Rocin, Rolacin, Uniklar, Veclam, Xylar, Zeclaren

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Also known as: Clarithromycin

Description

Synclar is used to treat many different types of bacterial infections affecting the skin and respiratory system. Synclar is also used together with other medicines to treat stomach ulcers caused by Helicobacter pylori. Synclar fights bacteria in the body. Synclar is also known as Clarithromycin, Maclar, Klaricid, Klacid, Clarimac, Claribid.

Dosage

The recommended daily dosage is 15 mg/kg/day divided every 12 hours for 10 days (up to the adult dose). Refer to dosage regimens for mycobacterial infections in pediatric patients for additional dosage information.

For the treatment of disseminated infection due to Mycobacterium avium complex (MAC), Synclar Filmtab and Synclar Granules are recommended as the primary agents. Synclar Filmtab and Synclar Granules should be used in combination with other antimycobacterial drugs (e.g. ethambutol) that have shown in vitro activity against MAC or clinical benefit in MAC treatment.

For treatment and prophylaxis of mycobacterial infections in adults, the recommended dose of Synclar is 500 mg every 12 hours.

For treatment and prophylaxis of mycobacterial infections in pediatric patients, the recommended dose is 7.5 mg/kg every 12 hours up to 500 mg every 12 hours.

Synclar therapy should continue if clinical response is observed. Synclar can be discontinued when the patient is considered at low risk of disseminated infection.

Overdose

If you overdose Synclar and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Synclar overdosage: nausea, vomiting, diarrhea, abdominal discomfort.

Storage

Store Synclar at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Synclar out of the reach of children and away from pets.

Side effects

The most common side effects associated with Synclar are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Synclar if you are allergic to its components or to clarithromycin or to similar medicines such as azithromycin (Zithromax), dirithromycin (Dynabac), erythromycin (E.E.S., E-Mycin, Ery-Tab, Erythrocin), troleandomycin (Tao). Do not take Synclar if you're pregnant or you plan to have a baby, or you are a nursing mother. Do not take Synclar if you take astemizole (Hismanal), cisapride (Propulsid), ergot medicine such as ergotamine (Ergomar, Ergostat, Cafergot, Ercaf, Wigraine), or dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), pimozide (Orap), terfenadine (Seldane). Do not take Synclar if you have liver disease, kidney disease, myasthenia gravis, porphyria; personal or family history of "Long QT syndrome". Try to be careful with Synclar usage in case you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement. Avoid consuming alcohol. It can be dangerous to stop Synclar taking suddenly.

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Sympathetic ganglia are composed of noradrenergic and cholinergic neurons. Aortic dissection after aortic valve replacement in patients with valvular aortic stenosis. Modulation of nitric oxide-induced apoptotic death of HL-60 cells by protein kinase C and protein kinase A through mitogen-activated protein kinases and CPP32-like protease pathways. Diaphorase-positive neurons in the cingulate cortex of human fetuses during the second half of gestation. In the present experiment, stereopsis based on spatial disparity cues was evaluated in cats using Julesz random-dot stereograms before and after sections of the optic chiasm, the corpus callosum or both. Histochemical staining of cadmium with 2-(8-quinolylazo)-4,5-diphenylimidazole. Changes of some immune functions after percutaneous transluminal coronary angioplasty (PTCA). Surprisingly, loss of Rtf1 or Cdc73, with little phenotypic consequence, results in loss of Paf1 factors from chromatin and a significant reduction in Paf1/Pol II association. We present the development of a family of biomimetic scaffolds composed of chemically crosslinked, elastin-like proteins designed to support neural regeneration through a combination of cell adhesion and cell-induced degradation and remodeling.

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A new anticonvulsant compound, zonisamide (1,2 benzisoxazole-methanesulfonamide), was studied in 10 adults with medically refractory partial seizures. Rhinophyma, a florid overgrowth of the tip of the nose with hypervascularity and nodularity, is an unusual progression of acne rosacea of unknown cause. Exercise and/or behaviour therapy appear to improve weight loss when added to diet. However single parameter DNA analysis, as currently used, can give inaccurate information when drug effects are associated with cytokinesis perturbations, in spite of various statistical and mathematical analyses. In general, sodium channel blocker is superior for defibrillation and potassium channel blocker is superior for prophylaxis of atrial fibrillation. Regulation of androgen receptor mRNA expression in hamster facial motoneurons: differential effects of non-aromatizable and aromatizable androgens. We used more frequently reported data on treatment efficacy (E) and risks (Rrx) to obtain an equation for the treatment threshold probability above which treatment should be given and below which it should be withheld. Flux determination allows the identification of target pathways for modification as validated by subsequent overexpression of the corresponding gene. coli endotoxin (250 micrograms/kg i.p.) was administered 24 h before they were given tetrachlormethane (CCl4) (1.5 ml/kg intragastrically), stimulation of liver DNA synthesis was observed during the first 48 h after administration of the hepatatoxin. In vivo implants containing 50 ng to 1 microgram adrenal-derived growth factors stimulate neovascularization in the chorioallantoic membrane of the chick embryo.

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The effect of age on the pharmacokinetics of the opioid antagonist nalmefene. The results of the study show that glyderinine possesses a marked cardioprotective effect. and terricolous Cladonia furcata (Huds.) Schrad., collected from an area with background arsenic concentrations, were exposed to 0, 0.1, 1 and 10 microg mL(-1) arsenate (As(V)) solutions for 24 h. Three patients developed colitis-like pictures, two of whom died as a result. An active area of research in STS is the use of novel combinations of agents, such as chemotherapy combined with multi-targeted agents. Since it is possible for the same weight of an enzyme to possess different activity levels, it is felt that activity rather than weight of an enzyme should be used in arriving at the above ratio. Conservative treatment is successful in most patients and if intervention is deemed medically necessary, endoscopic stent placement should be the procedure of choice. A highly hydrophobic and protruding loop at the base of the first repeat bears a critical virus-binding residue, thereby defining an important recognition epitope. Association and/or linkage studies to candidate genes have yielded a considerable number of reports showing significant genetic effects for the major histocompatibility complex (MHC), immunoglobulin heavy chain, T cell antigen receptor, and myelin basic protein loci.

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Furthermore, in sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) adult Thai S. Specific symptoms of depression reported most commonly in the elderly include loss of self-esteem, feelings of helplessness, and complaints of cognitive deficit. One student portrayed a patient presenting with cancer pain and was interviewed by the other medical student. Age is the principal determinant of quitting and neither educational achievement nor gender play a significant role in our study. However, the transport of AsIII and MAsIII in in any fish species has not been characterized. Specificity controls by enzyme immunoassay showed that antiserum to A.

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Peer support in the early postpartum period is effective in the prevention of postpartum depression among women identified as high-risk. A complete system should include data acquisition, data base management and archiving of data. This can be regarded as an adaptive mechanism to save energy, and thus to conserve protein and to protect organ function. The extent in the tumoral germinative compartment and the peritumoral microvascular network are explored and should in a near future make clear the progressive potential of cutaneous melanoma. Pleiotropic effects of statins in hypercholesterolaemia: a prospective observational study using a lipoproteomic based approach. Stimulation of prostaglandin E2 release in canine gastric parietal cells. Regional myocardial infarction of low-flow type in a neonate with tricuspid atresia. The MMDs obtained using the electrospray deposition method were compared with those obtained for hand-spotted samples. Cost-effectiveness was compared to recently published data on penetrating keratoplasty (PK).

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A nuclear translocation mechanism was hypothesized as a necessary link between the two forms. For this step, we also develop a simple univariate regression and extension method MFURE to extract candidate TFBSs from a large number of genes in the availability of microarray gene expression data. Linear pain scores for several gynecologic and digestive symptoms and impact on quality of life were recorded. A variety of doses of adrenocorticotropic hormone (2-2000 mU) caused the release of both catecholamines in situ which was unaffected by pre-treatment with the ganglion blocker, hexamethonium, or the serotonergic receptor antagonist, methysergide, but was abolished in calcium-free media. Saccharides as efficacious solubilisers for highly lipophilic compounds in aqueous media. The procedure was used in a 17 year old girl with an excellent hemodynamic result. These results indicate that telomere shortening in mTR-/- mice leads to progressive loss of organismal viability. The first mammalian Wnt to be discovered, Wnt-1, was found to be essential for the development of a large part of the mouse brain over 25 years ago. Further study of long-term effects of GLN in BMT seems warranted. Levamisole-contaminated cocaine can induce severe systemic vasculitis.

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Opiate addiction is a chronic, relapsing behavioral disorder where learned associations that develop between the abused opiate and the environment in which it is consumed are brought about through Pavlovian (classical) conditioning processes. An outbreak of neurological autoimmunity with polyradiculoneuropathy in workers exposed to aerosolised porcine neural tissue: a descriptive study. Chemical reversibility and stable low-potential NADH detection with nonconventional conducting polymer nanotubule modified glassy carbon electrodes. The third paper presents an innovative application that uses pharmacogenomic information to support personalized medicine. At room temperature, in Tris-HCl buffer (pH 7.4), both ASC and BH(4) were readily oxidized by dissolved O(2) or H(2)O(2). Growth and differentiation of fast and slow muscles in fetal sheep, and the effects of hypophysectomy. We found that the 5-HT3 receptors are widely distributed in the PG.

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Standard delay eyeblink classical conditioning is independent of awareness. The dominant Hg species in precipitation was mainly in the form of dissolved Hg, which indicates the pivotal role of reactive gaseous Hg within-cloud scavenging to wet Hg deposition. Importance of the alternative oxidase (AOX) pathway in regulating cellular redox and ROS homeostasis to optimize photosynthesis during restriction of the cytochrome oxidase pathway in Arabidopsis thaliana. SOD-1 and -2 staining was normal in the ALS cortical, brain stem and spinal motoneurons. For instance, vaginismus is akin to anismus and vesicourethral dyssynergia.

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The soluble fragment of this receptor (sCD23) participates in the regulation of IgE synthesis. Acute injuries were sustained mainly as a result of the nature of the terrain over which athletes train and compete. Novel OCT technologies offer crucial insight into corresponding changes at the level of the photoreceptor--retinal pigment epithelial--choriocapillary unit, identifying the biological limits of therapeutic interventions. Antigen 17NM was absent from 21 carcinomas, with some antigen-positive cells present in the others. We conducted a descriptive study of 23 women (35 pregnancies) with a history of stroke. The aim is to examine associations between bullying involvement in adolescence and mental health problems in adulthood. Pigs with side-to-end anastomoses had as rapid an evacuation as animals with straight coloanal reconstruction. Chlorpheniramine significantly reduced increase in microvascular permeability associated with immediate hypersensitivity, although cimetidine did not.

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Regeneration occurred on both sides of the resected tendon simultaneously. We studied here the clinical significance of GHRF test in evaluating therapeutic results in patients with acromegaly. Pharmacological modulation of cellular proteins as a means to block virus replication has been proposed as an alternative antiviral strategy that may be less susceptible than others to the development of viral drug resistance. Enlargement of the parathyroid gland, bone resorption and metastatic calcification in the solf tissues were found in rats with severe nephropathy. Ro 17-2301 had qualitatively similar activity to aztreonam and activity superior to that all the other antibiotics against the Enterobacteriaceae, but against Pseudomonas aeruginosa ceftazidime had equal or marginally better activity. Coherent wave transmission is shown to occur through a mechanism similar to that responsible for coherent backscattering. Choice of one more application compartments, of kinetics describing the input procedure and of elimination pathways is free. All three flavonoids resulted in prominent increase of G2/M population in Hep G2 cells, whereas an accumulation of sub G1 (hypoploid) peak in Hep 3B cells was observed. Over-all, operative intervention was successful, with 22 of 25 patients leaving the hospital alive. Rural interhospital helicopter transport of motor vehicle trauma victims: causes for delays and recommendations.

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Key questions in human bioenergetics await these results, and our laboratory is currently undertaking these studies. Point mutations in mitochondrial DNA, as found in MELAS, MERRF, NARP and other syndromes, are inherited via the maternal lineage. A content analysis was conducted on interview data to determine meaning and components of QOL perceived by the participants. The detection and confirmation of doping using endogenous substances are especially difficult for urine testing. We studied the effect of thymectomy on the development of hypertension in spontaneously hypertensive rats (SHR). Cystic artery pseudoaneurysm is a rare entity and as such there is no consensus on the clinical management of this condition. Rapid nongenomic E2 effects on p42/p44 MAPK, activator protein-1, and cAMP response element binding protein in rat white adipocytes.

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Heart failure in a macaw with atherosclerosis of the aorta and brachiocephalic arteries. The in vitro activation of murine macrophages by horseradish peroxidase (HRP) induced nitric oxide production in a dose-dependent manner, and increased the induction of NO-synthase by LPS. Duplex scan-directed placement of inferior vena cava filters: a five-year institutional experience. Throughout the secretory and maturation stages, a moderate and/or weak enzymatic reaction for both Ca- and Mg-ATPase was seen in the plasma membranes of the cells of the stratum intermedium and the papillary layer when incubated in media with levamisole. Multidrug resistance and the appearance of incurable diseases inspire the quest for potent therapeutics. There is a lack of published microsatellite data which characterizes Ribes spp. These were: first, a substance active on a rat fundic strip preparation and antagonized by N,N-DMT. In general, one of the main goals in stroke reduction is to control vascular risk factors such as hypertension, diabetes, dyslipidemia, and smoking cessation. The study comprised 149 524 white postmenopausal women aged 50 to 104 years (mean age, 64.5 years). Independently from the gestational age, placental and decidual cells expressed urocortin mRNA, with a 145 bp DNA band corresponding to the expected length.

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Malaysian isolates were branched into both groups, indicating multiple origins for contemporaneous outbreaks in that country. alphaENaC, GLUT1 and GLUT4 may be used as phenotypic markers of metabolically active, differentiated equine laminar keratinocytes. Mental work capacity of first-graders with different degrees of physical preparation having studied in a beginning kindergarten class. To investigate the efficacy of duloxetine in the treatment of pain and improvement in functional impairment and quality of life in patients with fibromyalgia from a pooled analysis of 4 placebo-controlled, double-blind, randomized trials. Radical cystectomy was selected as the initial treatment in 60 cases (the planned radical cystectomy group). When compared with normal controls, Zn, Br, and Rb levels in lung, liver, and skeletal muscle and Zn and Sr levels in bone from tumor-bearing mice exhibited large fluctuations at critical points in the tumor life cycle. In addition, we find that the size of LA endplates and the number of TSCs per LA junction were also increased by the testosterone treatment. Posterior registration as well as emission computed tomography was performed in 29 patients. Motivated by studies of clustering in self-propelled rods, we hypothesized that M. To apply the modified Hagerman score to patients with mental retardation and to relate clinical findings with cytogenetic and molecular diagnosis.

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Immunohistochemical analysis for IL-8 and VEGF was performed using specimens from 33 cancer patients and 6 control patients. Drug withdrawal and supplementation with niacin led to a rapid and sustained clinical improvement. A standardized method for measuring anti-F VIII: C inhibitors in haemophilia A by coagulation inhibition in agarose gel. This study suggests that with careful patient selection and follow levaquin antibiotic coverage -up, infectious corneal ulcers can be successfully managed on an outpatient basis. However, this association with generalized anxiety disorder was limited to females. Progress in resuscitation medicine allows an increasing proportion of patients to survive an out-of-hospital cardiac arrest.

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Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is caused by mutations in the SACS gene. For further optimization, new amino acid substitutions were introduced by rational design, based on the mutations identified during directed evolution. In this paper, we have investigated whether the pH-dependent membrane disruptive activity of PPAAc is retained after binding to a protein. Inhibition of thrombosis in an arterio-venous shunt occurs at low doses, which are almost ineffective cleocin gel cost in modifying the anticoagulant activity of plasma. Generally, neurons are more susceptible to Hg species induced cytotoxicity as compared to astrocytes.

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Cardiotocograms (CTG) evaluated qualitatively (visual) and quantitatively by biaxin antibiotic a moving window technique (width 10, shift 5 minutes) for baseline FHR, variability, and periodic alterations (accelerations and decelerations). CD4 T cells purified from infected mice proliferated in vitro in response to IOE Ags. To study this question, we measured the circulating thymic factor called thymulin (Zn-FTS) in hyperthyroid and hypothyroid patients. We describe a case of childhood growth hormone deficiency and hyperprolactinemia associated with absent pituitary stalk. Trends were determined using data collected at 5,214 visits of 653 heterosexual injection drug users who participated in the Amsterdam Cohort Study in Amsterdam, the Netherlands between April 1989 and May 1995. The strongest association was found between the total I-PSS and the QoL.

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