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Sitrox (Azithromycin)
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Sitrox

Sitrox is in a group of drugs called macrolide antibiotics. Sitrox fights bacteria in the body. Sitrox is used to treat many different types of infections caused by bacteria, such as respiratory infections, skin infections, ear infections, and sexually transmitted diseases. Sitrox may also be used for purposes other than those listed in this medication guide.

Other names for this medication:
Atizor, Azenil, Azibiot, Azifast, Azimax, Azimex, Azimit, Azimycin, Azithral, Azitropharma, Azomax, Azomycin, Aztrin, Azyter, Bactexina, Doromax, Ericiclina, Imbys, Magnabiotic, Naxocina, Novatrex, Pretir, Rarpezit, Triamid, Unizitro, Zaret, Zicho, Zimax, Zithrin, Zithrocin, Zithrogen, Zithrox, Zitrex, Zitrim, Zitroken, Zitrolid, Zitrotek, Zival, Zomax, Zymycin

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Cipro, Chloromycetin, Avelox, Flagyl, Biaxin

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Also known as: Azithromycin

Description

Sitrox (Sitrox tablets and Sitrox for oral suspension) contain the active ingredient azithromycin, a macrolide antibacterial drug, for oral administration. Sitrox has the chemical name (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl) oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one. Sitrox is derived from erythromycin; however, it differs chemically from erythromycin in that a methyl-substituted nitrogen atom is incorporated into the lactone ring. Its molecular formula is C38H72N2O12, and its molecular weight is 749.00.

Sitrox, as the dihydrate, is a white crystalline powder with a molecular formula of C38H72N2O12∙2H2O and a molecular weight of 785.0.

Sitrox is supplied as tablets containing azithromycin dihydrate equivalent to either 250 mg or 500 mg azithromycin and the following inactive ingredients: dibasic calcium phosphate anhydrous, pregelatinized starch, sodium croscarmellose, magnesium stearate, sodium lauryl sulfate, hypromellose, lactose, titanium dioxide, triacetin, and D&C Red #30 aluminum lake.

Sitrox for oral suspension is supplied in bottles containing azithromycin dihydrate powder equivalent to 300 mg, 600 mg, 900 mg, or 1200 mg azithromycin per bottle and the following inactive ingredients: sucrose; sodium phosphate, tribasic, anhydrous; hydroxypropyl cellulose; xanthan gum; FD&C Red #40; and spray dried artificial cherry, creme de vanilla, and banana flavors. After constitution, each 5 mL of suspension contains 100 mg or 200 mg of azithromycin.

Dosage

Dosage of Sitrox is setted individually according to nosology, disease severity and sensitivity of the pathogen. Dosage for adults for oral administration is 0.25-1 g 1 time/day; for children - 5-10 mg/kg 1 time/day. The duration of administration is 2-5 days.

Overdose

Adverse reactions experienced at higher than recommended doses were similar to those seen at normal doses particularly nausea, diarrhea, and vomiting. In the event of overdosage, general symptomatic and supportive measures are indicated as required.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not refrigerate or freeze the extended-release oral liquid. After water has been added to the powder, use the dose within 12 hours and throw away any unused liquid after your dose.

You may store the oral liquid at room temperature or in the refrigerator. Do not freeze the bottle. Do not keep the oral liquid for more than 10 days. Throw away any unused liquid after all doses are completed.

Side effects

The most common side effects associated with Sitrox are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You are allergic to any ingredient in Sitrox, to other macrolide antibiotics (eg, erythromycin), or to ketolide antibiotics (eg, telithromycin).

You are taking dofetilide, nilotinib, pimozide, propafenone, or tetrabenazine.

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