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Simpli (Azithromycin)
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Simpli

Simpli is a macrolide antibiotic of azalides group. Simpli inhibits RNA-dependent protein synthesis of sensitive microorganisms. It active against gram-positive bacteria: Staphylococcus aureus, Streptococcus spp. (including Streptococcus pneumoniae, Streptococcus pyogenes group A); gram-negative bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Neisseria gonorrhoeae, Campylobacter spp., Legionella pneumophila; anaerobic bacteria: Bacteroides fragilis.

Other names for this medication:
Azalid, Azenil, Azicin, Azigram, Azihexal, Azimycin, Aziphar, Azithrex, Azithrocin, Azithromycinum, Azithrus, Azitrin, Azitrix, Azomex, Azyth, Cinalid, Goldamycin, Hemomycin, Imbys, Macromax, Momicine, Neozith, Novatrex, Opeazitro, Oranex, Orobiotic, Ricilina, Sumamed, Tromic, Zifin, Zinfect, Zithromycin, Zithrox, Zitrim, Zitroneo, Zival

Similar Products:
Cipro, Sumycin, Omnicef, Amoxil, Rulide, Keflex, Chloromycetin, Avelox, Terramycin, Cleocin

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Also known as: Azithromycin

Description

The drug is an antibiotic used to treat a variety of bacterial infections, such as cat-scratch disease, ear infections, infections of the skin or surrounding tissue, and throat or tonsil infections.

Simpli is also used to treat lung and other respiratory infections, such as bronchitis, sinusitis, community acquired pneumonia, some cases of chronic obstructive pulmonary disease (COPD), and whooping cough (pertussis).

Doctors may also prescribe azithromycin for genital infections and sexually transmitted diseases, such as gonorrhea, infections of the urethra or cervix, genital ulcers, and severe pelvic inflammatory disease.

Simpli belongs to group of drugs known as macrolide antibiotics. They work by preventing bacteria from making their own proteins.

As with other antibiotics, to prevent the spread of drug-resistant infections, the Food and Drug Administration (FDA) strongly advises doctors to prescribe the drug only when there is proof, or a strong suspicion, that the infection is caused by bacteria against which Simpli is effective.

The FDA first approved Simpli under the brand name Zithromax in 1991. Pfizer Pharmaceuticals manufactures the drug.

Dosage

Dosage of Simpli is setted individually according to nosology, disease severity and sensitivity of the pathogen. Dosage for adults for oral administration is 0.25-1 g 1 time/day; for children - 5-10 mg/kg 1 time/day. The duration of administration is 2-5 days.

Overdose

If you overdose Generic Simpli and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Simpli overdosage: discomfort feeling in stomach, diarrhea, retching, nausea.

Storage

Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.

Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Simpli Tablet.

Side effects

The most common side effects associated with Simpli are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use this medication if you have ever had jaundice or liver problems caused by taking azithromycin. You should not use azithromycin if you are allergic to it or to similar drugs such as erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), clarithromycin (Biaxin), telithromycin (Ketek), or troleandomycin (Tao).

There are many other medicines that can interact with azithromycin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Take this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Azithromycin will not treat a viral infection such as the common cold or flu.

Avoid taking an antacid within 2 hours before or after you take azithromycin. Some antacids can make it harder for your body to absorb azithromycin.

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Analysis of variance and the Wilcoxon signed rank test were used to evaluate the distribution of Doppler signals within the prostate. Yersinia enterocolitica septicemia in an infant presenting as fever of unknown origin. Increases in preterm birth because of obstetric intervention among twins have not led to increases in twin neonatal mortality rates in the United States. Our results indicate that carboplatin possesses higher myelotoxic activity compared to cisplatin. Convulsions induced by the combination of enoxacin, a new antimicrobial, and nonsteroidal anti-inflammatory drugs including nimesulide, ketoprofen, pranoprofen and loxoprofen sodium, were investigated in mice. Changes in regional brain glucose metabolism in response to benzodiazepine agonists have been used as indicators of benzodiazepine-GABA receptor function. Fraction analysis showed that the total allergenic potency was distributed along pI values from 4.4 to 7, and most native proteins within this pI range bound specific human IgE as demonstrated by immunoblotting. None of the patients benefited from the use of sodium valproate therapy, however, pimozide reduced the severity of the dyskinesia in the two with longstanding hemiballismus. Although these agents are potent dilators of systemic venous capacitance vessels, present evidence indicates that they do not exert their beneficial hemodynamic and clinical effects by decreasing venous return to the heart. Sensitivity, specificity, and positive and negative predictive values for DGF were compared.

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Src family kinases are maintained in an assembled, inactive conformation by intramolecular interactions of their SH2 and SH3 domains. Association between alkaptonuria and selected polymorphic systems. Patients entering the initial study had received a diagnosis of active acromegaly within the previous 5 years. Our first-principles calculations indicate that in a confined nanospace, relative stabilities of the high-pressure B2 phase and the low-pressure B1 phase of KI are not necessarily flagyl dosage dogs giardia determined by their external pressures. In each catalytic cleft of the dimeric enzyme, substrates are recognized predominantly through van der Waals interactions with two tryptophan residues, and thereby the N-glycosidic bond of NAD is correctly exposed near a catalytic glutamate residue. Flow cytometry and immunohistochemical studies were performed on 48 small tumors with diameters less than 3 cm. A review of the reported cases of posttraumatic locked-in syndrome has allowed the authors to differentiate between two types: the first is due to primary brainstem injury and the second is due to secondary brainstem ischemia. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11682-007-9003-2) contains supplementary material, which is available to authorized users. The high rates of homicide observed in this typical rural South African population - particularly among men - underscore the need for urgent interventions to reduce this tragic and theoretically preventable loss of life in this population and similar South African settings. The Methanococcus jannaschii tRNA(Tyr)/tyrosyl-tRNA synthetase pair has been engineered to incorporate unnatural amino acids into proteins in Escherichia coli site-specifically.

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Aminophylline reduces hypoxic ventilatory depression: possible role of adenosine. Having a better understanding of the joint effects of these trends on longevity and quality of life will facilitate more efficient targeting of health care resources. Morphological and physiological characterization of different genotypes of faba bean under heat stress. Injured nerve block alters adjacent nerves spinal interaction in neuropathic rats. Specificity of the requirements for magnesium and calcium in the growth and metabolism of chick embryo fibroblasts. Despite the controversial discussions, which have accompanied it since its first introduction of into clinical medicine particularly in Switzerland, assisted reproductive medicine has come to acquire a firm standing in present-day society. The abnormal neurotransmission has been attributed to altered expressions of C-terminal products chloromycetin cost of the dystrophin gene in the outer plexiform layer, where photoreceptor cells form synapses with secondary neurons. Enhancement of enterotoxin production by carbon dioxide in Vibrio cholerae. The organ of growth for diaphysis is the epiphyseal disk und represents real a diaphyseal disk. It is well known that phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) plays important roles not only as a precursor lipid for generating second messengers but also as a regulator of cytoskeletal re-organization.

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