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Roxithromycine (Roxithromycin)
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Roxithromycine

Roxithromycine is indicated for the treatment of the following mild to moderately severe infections in children caused by or likely to be caused by susceptible micro-organisms: acute pharyngitis, acute tonsillitis and impetigo.

Other names for this medication:
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Also known as: Roxithromycin

Description

Each Roxithromycine tablet contains either 150mg or 300mg of the active ingredient roxithromycin. Each tablet also contains: hydroxypropylcellulose, poloxamer, povidone, colloidal anhydrous silica, magnesium stearate (470), purified talc (553), maize starch, hypromellose, anhydrous glucose, titanium dioxide (171), propylene glycol (1520). Roxithromycine does not contain gluten, sucrose, lactose, tartrazine or any other azo dyes.

Dosage

Roxithromycine is typically prescribed for a period of 7 to 14 days and patients should take the medication for as long as it has been prescribed to prevent the infection from returning even if they become asymptomatic. Patients should not however, take doses larger than has been prescribed as this can result in an overdose. Overdosing requires immediate medical intervention and may present with symptoms which include abdominal pain, nausea, diarrhea, vomiting, and a general and prolonged feeling of illness.

Overdose

Immediately telephone your doctor or pharmacist. Do this even if there are no signs of discomfort or poisoning.

Storage

Keep your tablets in the blister pack until it is time to take them. If you take the tablets out of the blister pack they may not keep well.

Keep the medicine in a cool, dry place where the temperature stays below 25 degrees C.

Do not store it or any other medicine in the bathroom, near a sink or on windowsill.

Do not leave it in the car. Heat and damp can destroy some medicines.

Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Side effects

The most common side effects associated with Roxithromycine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

The safety of roxithromycin has not been demonstrated in patients with impaired hepatic or renal function. Caution should be exercised if roxithromycin is administered to patients with impaired hepatic or renal function. If administered to patients with severe impaired hepatic function (eg. hepatic cirrhosis with jaundice and/or ascites), consideration should be given to reducing the daily dosage to half the usual dosage.

Prolonged or repeated use of antibiotics including roxithromycin may result in superinfection by resistant organisms. In the event of superinfection, roxithromycin should be discontinued and appropriate therapy instituted.

When indicated, incision, drainage or other appropriate surgical procedures should be performed in conjunction with antibiotic therapy.

Antibiotic associated pseudomembranous colitis has been reported with many antibiotics. A toxin produced by Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosis in patients who develop diarrhoea or colitis in association with antibiotic use (this may occur up to several weeks after cessation of antibiotic therapy). Mild cases usually respond to drug discontinuation alone. However, in moderate to severe cases, appropriate therapy with a suitable oral antibacterial agent effective against Clostridium difficile should be considered. Fluids, electrolytes and protein replacement therapy should be provided when indicated.

Roxithromycin, like erythromycin, has been shown in vitro to elicit a concentration - dependent lengthening in cardiac action potential duration. Such an effect is manifested only at supra – therapeutic concentrations. Accordingly, the recommended doses should not be exceeded. In certain conditions macrolides, including roxithromycin, have the potential to prolong the QT interval. Therefore roxithromycin should be used with caution in patients with congenital prolongation of the QT interval, with ongoing proarrhythmic conditions (ie uncorrected hypokalemia or hypomagnesaemia, clinically significant bradycardia), and in patients receiving Class IA and III antiarrhythmic agents.

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Nuclear IRS-1 was detected in T-antigen-positive cell lines and in T-antigen-positive biopsies from patients diagnosed with medulloblastoma. Percutaneous techniques have become widely accepted for the management of many patients with renal calculi. Echocardiographic predictors of survival in patients undergoing radiofrequency ablation of postinfarct clinical ventricular tachycardia. This has shown that temperature measurement by means of the chemical shift has experimental limits as well as the fact that overlapping signals may cause problems. This case indicates that a wide spectrum of neurological complications may develop in association with a varicella-zoster virus infection. All live newborn infants delivered at 35 gestational weeks or more were eligible. Rats, implanted chronically with monopolar electrodes in the MPC, received subcutaneous injections of nicotine (0.2, 0.4 and 0.8 mg/kg), mecamylamine (2.0, 4.0 and 8.0 mg/kg), pilocarpine (0.5, 1.0, 2.0 and 4.0 mg/kg), scopolamine (0.05, 0.1, 0.2, 0.4 and 0.8 mg/kg) and physostigmine (0.1, 0.2 and 0.4 mg/kg).

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The group additivity method for Arrhenius parameters is applied to hydrogen addition to alkenes and alkynes and the reverse beta-scission reactions, an important family of reactions in thermal processes based on radical chemistry. Cerebrospinal fluid S-100 protein levels in neurological pathologies. The alkane-degrader MPN method uses hexadecane as the selective growth substrate and positive wells are detected by reduction of iodonitrotetrazolium violet, which is added after incubation for 2 weeks at 20 degrees C. Using real-time RT-PCR, the relative expression levels of ERbeta1, ERbeta2 (ERbetacx), ERbeta3, ERbeta4 and ERbeta5 were studied. The influence of combretastatin A-4 and vinblastine on interstitial fluid pressure in BT4An rat gliomas. Factors in improved morbidity and mortality rates after total aortic valve replacement. The sensitivity that can be obtained depends on the background noise of the low noise preamplifier coupled to the device under test (DUT) that, at very low frequencies, is dominated by flicker noise.

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The menstrual cycle in the 28 study subjects remained under control during treatment, and there were no pregnancies. Spontaneous dissection of the exocranial internal carotid artery. So, in this way, we were able to focus only in the charge effects. A nationwide cross-sectional telephone survey of 505 Korean women aged 20 to 49 years was conducted using a proportionate quota and systematic random sampling method. It is unclear whether this is the result of platysmal weakness alone, or attributable to coinnervation of the lip depressor muscles by the cervical and marginal mandibular branches of the facial nerve.

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The MCF-7DXR/monocytes co-culture supernatant showed higher levels of IL-6 and IL-8 than the MCF-7S/monocytes co-culture supernatant. An extensive body of evidence has established that OC protect women against dysmenorrhea and menorrhagia, menstrual cycle irregularities, iron deficiency anemia, ectopic pregnancy, pelvic inflammatory disease, ovarian cysts, benign breast disease, endometrial cancer, and ovarian cancer. Secondary objective was evaluation of certain physiological changes in the animal following the induced menopause. ES in combination with PPI facilitates increased healing of ESD-induced ulcers, and can also improve the quality of ulcer healing. Some of the perineurial cells appeared hypertrophic and often showed mitotic figures. In addition to these cells, some cells grouped in the inner areas of the posterior PPD were revealed by catfish alpha, beta-GTH antiserum. We describe the operative technique and outcome in 6 patients with this unusual anomaly. Recombinant adenovirus was chosen as gene delivery vector to transfer and express the antisense RNA component of telomerase in tumor cells. Hallway versus treadmill 6-minute-walk tests in patients with chronic obstructive pulmonary disease.

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Assessing the transvalvular gradient of a Chinese-made jiuling solid pyrolytic carbon bileaflet heart valve prosthesis. Equally important to the patient and his family are efforts to function as well and as comfortably as possible throughout the remainder of his life. Clinical heterogeneity in cobalamin C variant of combined homocystinuria and methylmalonic aciduria. The prognosis for primary CNS malignant melanomas better than that for cutaneous melanoma. Recommendations were quantified using the evaluation of evidence guidelines developed by the Canadian Task Force on Preventive Health Care. For the fist time LP addendum into the perfusion medium was shown to provoke the activation of interstitial macrophages.

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PIP(2) signaling to the actin cytoskeleton transduces specific signals necessary for changes in morphology, motility, endocytosis, exocytosis, phagocytosis, and cell activation. Measuring central-chemoreflex sensitivity in man: rebreathing and steady-state methods compared. These strategies could be useful for analyzing downstream genes of ERalpha, and may contribute to elucidating the extensive signaling network of estrogen stimuli. Surgical treatment of experimental liver injuries in dogs with special evaluation of Polish-made cyanoacrylic glue. In 2 FAP patients in the early stage, both high (HFC: 0.12-0.4 Hz) and low frequency components (LFC: 0.04-0.12 Hz) in the heart rate spectrum, and basic (BW) and reflex waves (RW) in the vasomotion were all markedly suppressed. The clinician also must consider the costs in terms of available manpower and resources. Major focus is placed upon recent developments of novel NO donors, NO releasing device(s) as well as innovative improvements to conventional NO donors. To examine the relationship between polymorphism of serum amyloid A (SAA) 1, SAA 2 and Apolipoprotein E (Apo E) and susceptibility to AA amyloidosis (AA) in rheumatoid arthritis (RA).

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Oxidative stress induces the levels of a MafG homolog in hamster HA-1 cells. However, some subgroups need special consideration when planning interventions to increase PA levels. Collectively, these data indicate immunologic control is a key determinant of early HTLV-1 spread and have important implications for therapeutic intervention during HTLV-1-associated diseases. Furthermore, high-resolution melting and denaturing high-pressure liquid chromatography are reliable presequencing screening methods that reduce the sample amount for Sanger sequencing. What is the Surgical Benefit of Utilizing 5-Aminolevulinic Acid for Fluorescence-Guided Surgery of Malignant Gliomas?. HIV-related stigma and knowledge in the United States: prevalence and trends, 1991-1999. With highly myopic eyes excluded, the optic disc shape as single variable is not markedly important for pathogenesis, early diagnosis and differential diagnosis of the glaucomas. In the dsy2 mutant, localization of ASY1 is affected, and loading of the central element ZIPPER1 (ZYP1) is disrupted.

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Identification of a DinB/UmuC homolog in the archeon Sulfolobus solfataricus. The effect of follicle stimulating hormone (FSH) and chorionic gonadotropin (HCG) on the rat ovary in experimental follicular persistence. Observed longevity was compared to industry-projected longevity obtained from product performance reports. Feeding clays also causes morphological changes in the intestinal mucosa such as an increase in villus height and an increase in the villus height to crypt depth ratio. The immunohistochemical profile, especially S100 protein expression and absence of epithelial membrane antigen, was useful to recognize the microglandular adenosis and the carcinoma of alveolar architecture, while invasion was suggested by the basement membrane disruption highlighted with anti-collagen IV immunostaining.

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GCFs were collected from 10 individuals with filter strips from two healthy sites and four sites with deep pathological periodontal pockets, two of which showed horizontal bone loss and two with angular bone loss. The syndrome, involving the left ankle and hindfoot, developed twelve days after a classical gouty attack involving the first metatarso-phalangeal joint of the same foot. Improved detection of lung cancer arising in diffuse lung diseases on chest radiographs using temporal subtraction. Heritable alteration of DNA methylation induced by whole-chromosome aneuploidy in wheat. Reproducibility of measurements of regional resting and hyperemic myocardial blood flow assessed with PET. Several phosphorylations are known to occur in the N-terminal transactivation domain of human p53. Hypertensive emergencies and urgencies: pathophysiology and clinical aspects. Vaccination of gilts with low level (passive) immunity resulted in antibody responses comparable to those recorded in susceptible pigs. No evidence of mu-calpain autolysis, calpain-mediated alpha-spectrin degradation, or hematoxylin and eosin neuronal pathology was detected in the contralateral cortex. In this study, we aimed to use FT-IR spectroscopy to determine serum concentrations of chylomicron-triglyceride (TG) and very low density lipoprotein (VLDL)-TG.

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Protein containing quality control (QC) material in ampoules for blood gas, pH and electrolyte analysers has been manufactured using buffered protein (Bovine Serum Albumine, BSA) solution with sodium bicarbonate and chloride salts. Compound 5 is prepared by catalytic hydrogenation of bilobol isolated from Ginkgo biloba. Mucin production in the middle ear in response to lipopolysaccharides. We present a case of a 56-year-old African American woman with slurred speech and altered mental status that was initially suspected to have stroke. An improved method for the isolation of high yields of bacteriophage lambda DNA. RAI gene was isolated in a yeast two-hybrid screen using the central region of p65 as bait. We present the development of a Comprehensive database of 12 076 invariant Peptide Signatures (CoPS) derived from 52 bacterial genomes with a minimum occurrence in at least seven organisms. The meningeal cells stained intensely with periodic acid-Schiff stain and intracellular contrast medium was ultrastructurally apparent in phagolysosomes. The clinical presentation of DAVFs with spinal venous drainage was compared with the extent of the drainage.

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Human fibronectin contains distinct adhesion- and motility-promoting domains for metastatic melanoma cells. The molecular compositions were observed to change during development of the chick brain. This group was compared with a matched group of normal children walking on their toes and to a group of patients with cerebral palsy and equinus deformities. Variables known to influence ICP, such as medications, cerebrospinal fluid (CSF) drainage, suctioning, and other interventions, were taken into account. The linear lesion on the chest CT is uncommon in paragonimiasis, but the finding is thought to be useful for the diagnosis of this disease. Our results indicated that glucose could acted as an essential electron donor, and clay minerals significantly enhanced microbial Cr(VI) reduction rates by improving the consumption rate of glucose and stimulating the growth and propagation of P.

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Altered diffusivity and reduced volume of the caudate nucleus amoxil 500 mg in presymptomatic HD gene carriers indicate that the neostriatum is affected well before the onset of symptoms. The administration of intravenous sulfamethoxazole and trimethoprim, erythromycin lactobionate, and tobramycin sulfate therapy correlated with recovery. Anomalous signal of solvent bromides used for phasing of lysozyme. Our data suggest that the mechanism of cAMP accumulation in stimulated Treg involves the AC7 activation and provide new insight into the modulation of Treg activities via AC inhibition or stimulation in various pathological processes like tumor and autoimmune diseases. Immunoglobulin-A and the pathogenesis of schistosomal glomerulopathy.

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The procedure is performed by the neurotologist and causes minimum morbidity. Irritable bowel syndrome and bronchial hyperresponsiveness: is there a link?. This suggests that protection of GC by heated NGPS did not occur on the surface of GC. The data show that severe arthroses without any synovitic reactions as well as cases with inactive chronic synovitis showed small total activities of LDH, whereas cases with clinical and macroscopic-anatomically active synovitis (including the so-called activated arthroses) showed a great total activity of LDH. This phenomenon of spontaneous reappearance after forced embolization can be followed during several hours. The functions of beta-arrestin1 to facilitate clathrin-mediated endocytosis of the beta2-adrenergic receptor and to promote agonist-induced activation of extracellular signal-regulated kinases (ERK) are regulated by its phosphorylation/dephosphorylation at Ser-412. Validation of an integral conceptual model of frailty in older residents of assisted living facilities. Severe forebrain ischemia in rats was induced by four-vessel occlusion with reducing the systolic arterial pressure to 100 mmHg. In db/db mice that had received MIN6 cells, blood insulin levels were restored and blood glucose levels were reduced to those of non-diabetic sumycin antibiotic mice, although they remained obese. The effects of PDE inhibitors on TNF-alpha secretion from rat heart were evaluated in this study.

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To study the safety and effect of Leptospiral outer membrane vaccine. High concentrations of SHS constituents known to cause health effects indicate that indoor air quality in waterpipe tobacco venues may adversely affect the health of employees and customers. Early intervention is being tested 1) in a randomised controlled multi-centre trial consisting of a specially developed cognitive-behavioural therapy in the early (prepsychotic) prodromal state and 2) on additional treatment with appropriate doses of amisulpride in the late prodromal (early psychotic) state. Ubiquitination and proteasome degradation of the E6 proteins of human papillomavirus types 11 and 18. Significant clinical signs were loss of body weight and reduced feed consumption. Growth factor(s) produced during infection with an adenovirus variant stimulates proliferation of nonestablished epithelial cells. The algorithm can also be used with virtually any type of matrix-based symmetry, including conjugate symmetry.

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CAD/DFF40 is responsible for the degradation of chromosomal DNA into nucleosomal fragments and subsequent chromatin condensation during apoptosis. Two published subcellular subfractionation techniques employing Ficoll-sucrose or sucrose-density gradient centrifugation, respectively, are evaluated for their capacity to yield fractions containing free mitochondria and synaptosomes from a single rat forebrain. Only patients receiving less than 50 rad show early complete recovery 12 months after radiation therapy. These findings should be taken into account when conducting clinical and epidemiological studies in which patients with both heart failure and hypertension are included. Trends in incidence rate, health care consumption, and costs for patients admitted with a humeral fracture in The Netherlands between 1986 and 2012. Influences of inactivity and indomethacin on soleus phosphatidylethanolamine and size. The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts. In this paper, we describe the karyotypic stability of human fibroblasts immortalized by expression of hTERT.

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The presence of intraarticular hemorrhage and cyst fluid in bone cavities was recorded. The total activity, extracted at both low and high ionic strengths, does not change throughout the differentiative process, although DNA synthesis stops at the moment of fusion. The representation of the category was assessed by category generation, category ratings, and item sortings. It is attempted to solve some problems in modernization and datalization of the collation of ancient literatures of Traditional Chinese Medicine. Preparation of monoclonal antibodies against neurotoxic agent raised from an organophosphorus hapten and its characterization. The Cytochrome P450 Enzymes of Hepatic Drug Metabolism: How are their Activities Assessed In Vivo, and what is their Clinical Relevance?.

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