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Roksolit (Roxithromycin)
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Roksolit

Roksolit is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Roksolit is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring.

Other names for this medication:
Acevor, Aristomycin, Asmetic, Assoral, Bazuctril, Biaxsig, Biostatik, Claramid, Crolix, Dorolid, Elrox, Erybros, Infectoroxit, Macrolid, Macrosil, Makrodex, Monobac, Nirox, Odonticina, Overal, Pedilid, Ramivan, Redotrin, Remora, Renicin, Ritosin, Rokilide, Roksimin, Rolicyn, Rolid, Romyk, Rossitrol, Rotramin, Roxacine, Roxithromycin, Roxithromycine, Roxithromycinum, Roxitromicina, Rulid

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Chloromycetin, Avelox, Cipro, Ceftin, Ilosone, Amoxil, Duricef, Myambutol, Cefixime, Rulide

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Also known as: Roxithromycin

Description

Roksolit is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Roksolit is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring. It is also currently undergoing clinical trials for the treatment of male-pattern hair loss.

Roksolit is available under several brandnames. Roksolit is not available in the United States. Roksolit is available in Australia, Israel and New Zealand. Roksolit has also been tested to possess antimalarial activity.

Roksolit prevents bacteria from growing, by interfering with their protein synthesis. Roksolit binds to the subunit 50S of the bacterial ribosome, and thus inhibits the synthesis of peptides. Roksolit has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila.

Dosage

Take Generic Roksolit by mouth with food. If you have trouble swallowing the tablet whole, it may be crushed or chewed with a little water. Swallow Generic Roksolit tablets whole with a glass of water. Generic Roksolit should be taken at least 15 minutes before food or on an empty stomach (i.e. more than 3 hours after a meal). Generic Roksolit works best if you take it on an empty stomach. For treating bacterial infections, Generic Roksolit is usually taken for 5 to 10 days. If you want to achieve most effective results do not stop taking Generic Roksolit suddenly.

Overdose

Immediately telephone your doctor or pharmacist. Do this even if there are no signs of discomfort or poisoning.

Storage

Keep your tablets in the blister pack until it is time to take them. If you take the tablets out of the blister pack they may not keep well.

Keep the medicine in a cool, dry place where the temperature stays below 25 degrees C.

Do not store it or any other medicine in the bathroom, near a sink or on windowsill.

Do not leave it in the car. Heat and damp can destroy some medicines.

Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Side effects

The most common side effects associated with Roksolit are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

The safety of roxithromycin has not been demonstrated in patients with impaired hepatic or renal function. Caution should be exercised if roxithromycin is administered to patients with impaired hepatic or renal function. If administered to patients with severe impaired hepatic function (eg. hepatic cirrhosis with jaundice and/or ascites), consideration should be given to reducing the daily dosage to half the usual dosage.

Prolonged or repeated use of antibiotics including roxithromycin may result in superinfection by resistant organisms. In the event of superinfection, roxithromycin should be discontinued and appropriate therapy instituted.

When indicated, incision, drainage or other appropriate surgical procedures should be performed in conjunction with antibiotic therapy.

Antibiotic associated pseudomembranous colitis has been reported with many antibiotics. A toxin produced by Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosis in patients who develop diarrhoea or colitis in association with antibiotic use (this may occur up to several weeks after cessation of antibiotic therapy). Mild cases usually respond to drug discontinuation alone. However, in moderate to severe cases, appropriate therapy with a suitable oral antibacterial agent effective against Clostridium difficile should be considered. Fluids, electrolytes and protein replacement therapy should be provided when indicated.

Roxithromycin, like erythromycin, has been shown in vitro to elicit a concentration - dependent lengthening in cardiac action potential duration. Such an effect is manifested only at supra – therapeutic concentrations. Accordingly, the recommended doses should not be exceeded. In certain conditions macrolides, including roxithromycin, have the potential to prolong the QT interval. Therefore roxithromycin should be used with caution in patients with congenital prolongation of the QT interval, with ongoing proarrhythmic conditions (ie uncorrected hypokalemia or hypomagnesaemia, clinically significant bradycardia), and in patients receiving Class IA and III antiarrhythmic agents.

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Increased hepatocytic mitotic activity as a diagnostic marker of acute arsenic intoxication. More recent studies suggest higher cumulative conception rates in women with PCOS when compared with controls. The adenovirus E1A gene product trans-activates a number of viral and cellular promoters. Osmotic stress induces changes in the expression of various genes including those associated with drought tolerance, cell wall metabolism and defense. Isolation and characterization of lectin binding proteins from murine lymphoid cells. Expression of luminal and basal cytokeratins in human breast carcinoma. The population is aging leading to an increase of potential retirees. Other colleges and schools are encouraged to collaborate with an instructional design and development expert to improve the pharmacy curriculum.

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Theoretical study for the treatment of pancreatic cancer using electric pulses. Administration of intravenous gamma globulin resulted in rapid improvement. Absolute configuration of 2,3-dihydroxy-3-methylpentanoic acid, an intermediate in the biosynthesis of isoleucine, and its identity with the esterifying acid of the pyrrolizidine alkaloid strigosine. This disorder appears to be caused by a malfunction of the normal equilibrial control mechanism related to the brainstem or the central nervous system. Present status of invasive examinations in the diagnosis of heart valve diseases in adults. Decoy oligonucleotide characterization of GATA-4 transcription factor in hypertrophic agonist induced responses of cardiac myocytes. The effect of acute third ventricle cadmium administration on the drinking behavior of adult male rats under different situations was studied.

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We used the crystal structure of the GDPRan-NTF2 complex to design mutants in the switch II loop of Ran to probe the contribution of Lys71, Phe72 and Arg76 to this interaction. Simple radiological examination of the thorax in pectus excavatum. A 63-year-old woman with muscle weakness, myotonia, and parkinsonism. The authors found the antimicrobial spray can reduce pain during the recovery period, while providing equivalent antibacterial protection to the control treatment (AQUACEL Hydrofiber Wound Dressing, ConvaTec, Bridgewater, NJ) based on skin culture tests. Protection of Neonatal Broiler Chickens Following in ovo Delivery of Oligodeoxynucleotides Containing CpG Motifs (CpG-ODN) Formulated with Carbon Nanotubes or Liposomes. Without OFRS, a marked increase of endothelaemia was observed after 30-60 min ischaemia showing a second peak after the release of the ligature. A family history in one of these two cases and in another case reported in the literature raises the problem of a possible recurrence. Tandem application of sodium lauryl sulfate and n-propanol does not lead to enhancement of cumulative skin irritation. The results indicate that this sequence actually functions as the active site in CPase Taq, showing that CPase Taq is a novel type of zinc-dependent CPase that possesses the His-Glu-X-X-His active-site motif. Similar to FUS, the RBM14 PLD also forms hydrogels with amyloid-like properties.

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Epidemiological characteristic of first case of locally identified A/H1N1 secondary cases caused by imported source of infection in China. Future considerations for the medical management of nerve-agent intoxication. The review is based on the scientific literature and own professional experiences. Impairment of performance when a discriminative stimulus is correlated with a reinforcement contingency. Therapeutic percutaneous injections in the treatment of malignant acetabular osteolyses. We present a pediatric LTH grading scale with substantial interrater reliability to facilitate standardization of endoscopy findings and promote outcomes-based research for OSA surgery in children. The Medweb server used the Linux/UNIX operating system on a Pentium 333-MHz processor with 128 MB of RAM. The pharmacological investigations of the central action of benzydamine. The other twin, who amoxil 500 mg dosage instructions has suffered infrequent epileptic seizures since the age of 6 days, is still grossly autistic.

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