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Ritosin (Roxithromycin)
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Ritosin

Ritosin is an antibiotic that is used to treat infections such as infections of the chest, tonsils, skin or genitals. It works by killing or stopping the growth of bacteria (bugs). Like all antibiotics, Ritosin is not effective against infections caused by viruses.

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Acevor, Asmetic, Assoral, Bazuctril, Biostatik, Dorolid, Erybros, Floxid, Infectoroxit, Klomicina, Macrolid, Macrosil, Makrodex, Monobac, Overal, Ramivan, Remora, Ritosin, Rokilide, Rokithrid, Roksimin, Rolicyn, Romyk, Roxacine, Roxithromycine, Rulid

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Also known as: Roxithromycin

Description

Each Ritosin tablet contains either 150mg or 300mg of the active ingredient roxithromycin. Each tablet also contains: hydroxypropylcellulose, poloxamer, povidone, colloidal anhydrous silica, magnesium stearate (470), purified talc (553), maize starch, hypromellose, anhydrous glucose, titanium dioxide (171), propylene glycol (1520). Ritosin does not contain gluten, sucrose, lactose, tartrazine or any other azo dyes.

Dosage

Take Generic Ritosin by mouth with food. If you have trouble swallowing the tablet whole, it may be crushed or chewed with a little water. Swallow Generic Ritosin tablets whole with a glass of water. Generic Ritosin should be taken at least 15 minutes before food or on an empty stomach (i.e. more than 3 hours after a meal). Generic Ritosin works best if you take it on an empty stomach. For treating bacterial infections, Generic Ritosin is usually taken for 5 to 10 days. If you want to achieve most effective results do not stop taking Generic Ritosin suddenly.

Overdose

Immediately telephone your doctor or pharmacist. Do this even if there are no signs of discomfort or poisoning.

Storage

Keep the tablets in the foil until it is time to take them.

Keep the tablets/in a cool dry place where the temperature stays below 30 degrees C.

Do not store Ritosin or any other medicine in the bathroom or near a sink.

Do not leave it in the car on hot days or on window sills.

Heat and dampness can destroy some medicines.

Keep it where children cannot reach it.

A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Side effects

The most common side effects associated with Ritosin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

The safety of roxithromycin has not been demonstrated in patients with impaired hepatic or renal function. Caution should be exercised if roxithromycin is administered to patients with impaired hepatic or renal function. If administered to patients with severe impaired hepatic function (eg. hepatic cirrhosis with jaundice and/or ascites), consideration should be given to reducing the daily dosage to half the usual dosage.

Prolonged or repeated use of antibiotics including roxithromycin may result in superinfection by resistant organisms. In the event of superinfection, roxithromycin should be discontinued and appropriate therapy instituted.

When indicated, incision, drainage or other appropriate surgical procedures should be performed in conjunction with antibiotic therapy.

Antibiotic associated pseudomembranous colitis has been reported with many antibiotics. A toxin produced by Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosis in patients who develop diarrhoea or colitis in association with antibiotic use (this may occur up to several weeks after cessation of antibiotic therapy). Mild cases usually respond to drug discontinuation alone. However, in moderate to severe cases, appropriate therapy with a suitable oral antibacterial agent effective against Clostridium difficile should be considered. Fluids, electrolytes and protein replacement therapy should be provided when indicated.

Roxithromycin, like erythromycin, has been shown in vitro to elicit a concentration - dependent lengthening in cardiac action potential duration. Such an effect is manifested only at supra – therapeutic concentrations. Accordingly, the recommended doses should not be exceeded. In certain conditions macrolides, including roxithromycin, have the potential to prolong the QT interval. Therefore roxithromycin should be used with caution in patients with congenital prolongation of the QT interval, with ongoing proarrhythmic conditions (ie uncorrected hypokalemia or hypomagnesaemia, clinically significant bradycardia), and in patients receiving Class IA and III antiarrhythmic agents.

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To study the change of levels of plasma heat stress protein 70 (HSP70) and cytokine and their interrelationship in pathogenicity of heat apoplexy. Recent findings suggest an upregulation of renin-angiotensin system (Lam SY, Liu Y, Ng KM et al. The majority of heterozygote positions identified are non-synonymous, i.e. The total protein concentration in the exudate reached a maximum 4 days after carrageenan injection and then slightly decreased, whereas the concentration of S100A9 reached a maximum at day 3 and then decreased rapidly. The results suggest that dipolar interactions associated with atomic-scale charge displacements or molecules can be probed by noncontact atomic force microscopy. The present innovative approach is capable of providing a membrane with anti-adhesive and antiproliferative properties, thus encouraging in vivo studies to provide a better simulation of the clinical situation. Data analysis showed a high level of heterogeneity of gene expression between MDS patients, most probably reflecting the underlying karyotypic and genetic heterogeneity.

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