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Polibiotic (Metronidazole)
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Polibiotic

Flagyl is an oral antiprotozoal and antibacterial. It is thought to work by entering the bacterial cell, acting on some components of the cell, and destroying the bacteria. Treating certain infections caused by bacteria or amoebas. It may also be used for other conditions as determined by your doctor.

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Also known as: Metronidazole

Description

Polibiotic (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Polibiotic is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.

Dosage

The usual adult oral dosage is 7.5 mg/kg every six hours (approx. 500 mg for a 70-kg adult). A maximum of 4 g should not be exceeded during a 24-hour period.

The usual duration of therapy is 7 to 10 days; however, infections of the bone and joint, lower respiratory tract, and endocardium may require longer treatment.

Patients with severe hepatic disease metabolize metronidazole slowly, with resultant accumulation.

Overdose

Single oral doses of Polibiotic, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Polibiotic has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Polibiotic overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.

Storage

Store Polibiotic at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Polibiotic out of the reach of children and away from pets.

Side effects

The most common side effects associated with Polibiotic are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Meningitis Not Caused by an Infection, Decreased Neutrophils a Type of White Blood Cell, Habit of Drinking Too Much Alcohol, Alcohol Intoxication, Lower Seizure Threshold, Disorder of the Brain, peripheral neuropathy, prolonged QT interval on EKG, Severe Liver Disease, seizures, Cockayne syndrome

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Remaining challenges and exciting prospective directions are also presented. These findings indicate that Group 1 and Group 2 endometrial carcinomas may constitute two different biologic entities and, thus, encourage further basic and clinical research to develop specific therapies for patients diagnosed to have endometrial cancer. Hematological analysis including complete blood counts and quantification of Hb levels were performed by capillary electrophoresis. Soldiers are now primarily involved in peacekeeping or humanitarian missions. This volume, a measure of the cardiac motion effect on coronary artery stent position during the cardiac cycle, represents a moving gross target for stereotactic external beam radiation therapy. Research on no-suicide contracts (frequency surveys, assessments of behavior after contracting, and opinions of users) has limitations common to naturalistic studies, and is now ready for more rigorous methods. Although the relative weight of different physiological and molecular mechanisms and the dose-response on arterial wall properties have yet to be determined, n-3 PUFA have the potential to beneficially impact arterial wall remodeling and cardiovascular outcomes by targeting arterial wall stiffening and endothelial dysfunction.

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The hyperthermic response to MK-212 was attenuated 1 hr and 48 hr (but not 8, 24 or 96 hr) after the administration of mianserin. The importance of such granulomas for the interpretation of lymphoscintigraphic findings is pointed out. Electronic databases including Scopus, SciFinder, Pubmed, Google Scholar and Google were used as data sources. In this study, we compared the efficacy of citalopram and venlafaxine in major depression, which has not yet been studied in Iran. In cadaver ears, a helical rim defect of 5 mm was enlarged sequentially to 10 mm, 15 mm, and finally 20 mm. Collected systemic and local reactions after vaccination and calculated the incidence of adverse reactions.

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To evaluate the effect of prednisone alone, compared with a combination of prednisone and vincristine, on platelet counts in bleeding dogs with severe primary immune-mediated thrombocytopenia (IMT). The same two size- and ionic-strength-dependent transitions in sedimentation behaviour are observed as for other chromatins (rat liver, chicken erythrocyte) with shorter DNA repeat lengths. The aberrant pharmacodynamic responses to neuromuscular relaxants in burn patients include the potential for lethal hyperkalemia with the administration of depolarizing relaxant, succinylcholine, and a 2.5- to 5.0-fold increase in the dose or plasma concentration requirement for nondepolarizing relaxant, including D-tubocurarine, metocurine, pancuronium, and atracurium. Further studies indicate that Fra-2 containing AP-1 complexes can transactivate the MyoD enhancer/promoter. Human umbilical vein endothelial cells(HUVECs) were cultured and the effect of CD226 on the adhesion between activated HUVEC and activated PBMC were observed by Leica inverted microscope and scanning electron microscope. Nonpathogenesis of simian immunodeficiency virus infection is associated with reduced inflammation and recruitment of plasmacytoid dendritic cells to lymph nodes, not to lack of an interferon type I response, during the acute phase. The AgInSbTe nanopillar type phase change device with 200 nm of diameter was fabricated by nanoimprint lithography and was reversibly changed between the resistances of 10(4) and 10(6) Omega by applying set/reset pulses using conducting atomic force microscopy. Porokeratosis ptychotropica is a rare variant of porokeratosis that is classically located on the gluteal and perianal regions, seldom extending to the genitalia. Cells were positive by terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labelling (TUNEL) staining under these exposure conditions. Inhibition of GABA-transaminase activity was particularly marked in postconvulsive period.

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Desired features of the cage self-assembly process, such as reversibility in the presence of a competitive ligand and self-recognition of the cavitand components, have been assessed. This is a costly piece of research and it is important to select the most appropriate animal. Urinary markers of estrogen metabolism 2- and 16 alpha-hydroxylation in premenopausal women. How have these crucial changes affected AIDS policies in America?. Ferritinemia as an indicator of systemic disease activity in children with systemic juvenile rheumatoid arthritis. These altered genes encode proteins with a wide range of functions within cells, and thus deletion of normal gap junction expression appears to result in globally altered glial functions in addition to disruption of intercellular communication. Comparison with the classical linear method showed that neglecting nonlinearities leads to an overestimation of the forward and backward pressure wave amplitudes. Several platforms have been used to generate the primary data for microsatellite analysis of malaria parasite genotypes.

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The cases of twenty-six patients who received a massive allotransplant of frozen bone, with a known degree of histocompatibility between the donor and the recipient, were studied. Class-specific antibodies to Streptococcus mutans in human serum, saliva and breast milk. A functional polymorphism in the upstream regulatory region of the serotonin transporter gene (5-HTTLPR) has been recently reported to be associated with mood disorders. Giant Condyloma Acuminatum of Vulva Frustrating Treatment Challenge. On the other hand SMCs in sacs obtained from boys with hydrocele are in an intermediate state of differentiation-dedifferentiation. Clinical inflammation and inflammatory cell numbers were less in rats injected with the Mutant I strain. To distinguish procedural from working memory components, a forced-choice paradigm of the radial maze was used in the second experiment. Sensitivity to perceptual context (anchoring) has been suggested to contribute to the development of both oral- and written-language skills, but studies of this idea in children have been rare. AGE-HSA increased the migration capacity and inflammatory responses of rat AFs via RAGE-MAPK-NF-kappaB pathways. Their demographic (age, gender, race/ethnicity, education, relationship status, employment, and income), cancer-related (diagnosis, current health problem, age at diagnosis, and years since diagnosis), and psychosocial (social support and optimism) PTG correlates were examined using descriptive, correlational, and regression analyses.

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A comparative method for protein extraction and 2-D gel electrophoresis from different tissues of Cajanus cajan. Given the heterogeneity of this disease process and the potential risk of immunoediting out a selected, treatment-refractory tumor cell population, the concurrent use of multiple modalities that target disparate tumor characteristics may be of greatest therapeutic relevance. This column also separated BCG85B from a 17-kDa protein with an N-terminal amino acid sequence of A-V-P-I-T-G-K-L-G-S-E-L-T-M-T-D-( )-V-G-Q, which is similar to the sequence of MPT63. Additionally, there was serologic evidence for involvement of bovine adenovirus type 3 in the epizootics in 2 of the groups of calves, but not in the 3rd. In this article, we outline our view of how concentration shields against distraction. To examine the short-term effects of STN stimulation on several tests sensitive to executive function and the long-term effects of STN stimulation on a global cognitive scale. Extensive cutaneous necrosis (ECN) associated with antiphospholipid antibodies is a rare presentation.

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Effect of an inorganic ion on the activity of parathyroid glands. Relapse infection after chemotherapy in goats experimentally infected with Trypanosoma brucei: pathological changes in central nervous system. Development of form 2 mycobacteria on autoclaved Lowenstein-Jensen medium. OVX ADSCs also increased tenocyte proliferation and healing rate but less compared with sham ADSCs. An operon with homology to the dppABCDF genes required to transport dipeptides in bacteria was identified in the N2-fixing symbiont, Rhizobium leguminosarum. Nevertheless, recent reports have provided new evidence on a putative atherogenic role of LDL(-).

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Pulmonary hypertension, cardiac surgery, administration of steroids and calcium chloride, in addition to transitory acute renal failure may be the multicausal factors that produced this myocardial calcification. The diagnosis was established by measuring anti-CMV serum antibodies (IgM and IgG) using the Enzyme-Linked Fluorescent Assay (ELFA) technique, and by detecting CMV-DNA using the PCR technique. Assessment took place 26 weeks and 12-18 months after inclusion in the study with a pain questionnaire and a physical examination. Just under 900 worker health and safety representatives in Ontario completed surveys which asked them to report on the amount of time they devoted to different types of representation activities (i.e., technical activities such as inspections and report writing vs. Many genes were identified that are differentially expressed in the different MDS subtypes and AML. Using nationally representative data from the 2005 National Health Interview Survey, we examined the relationship between obesity and CRC screening for white and African-American women aged 50 and older. Mechanism of DNA gyrase-mediated illegitimate recombination: characterization of Escherichia coli gyrA mutations that confer hyper-recombination phenotype. In one animal all clones were V beta 8 positive, whereas in the others, all clones were negative. The binding surface on PLCgamma1 that mediates recognition by Itk highlights a nonclassical binding activity of the well-studied SH2 domain providing further evidence that SH2 domains participate in important signaling interactions beyond recognition of phosphotyrosine.

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Biodegradation of malachite green by Brevibacillus laterosporus MTCC 2298. Induction of pleckstrin by the Epstein-Barr virus nuclear antigen 3 family. Occupational health injuries: a brief review of three disorders. This concentration procedure was validated for Dermatophagoides pteronyssinus, timothy pollen, birch pollen and cat dander extracts and used in a stability study in which three batches were stored for 1 year at 6 degrees C and 25 degrees C. Clinical impact of dyslipidemia for coronary plaque vulnerability in acute coronary syndrome without metabolic syndrome. Only vitamin A and carotenoid levels were positively correlated to body mass index. Multi-morphologic polymer nano-assemblies, such as micelles and vesicles, have been intensively myambutol online studied recently by scientists in the multidisciplinary fields for their promising applications in bioengineering, biomedicine and pharmaceutics. The correlation of results with those obtained with standard reference methods, reproducibility, and ease of operation were investigated. Use of fax-back surveillance to determine epidemiologic and clinical characteristics of patients diagnosed with hepatitis C in Waterbury, Connecticut.

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In vitro comparative activity of meropenem with 15 other antimicrobial agents against 1798 Pseudomonas aeruginosa isolates in a French multicenter study. The phosphatidylinositol 3-kinase (PI3-K) inhibitor wortmannin and the mammalian target of rapamycin (mTOR) inhibitor rapamycin, but not the mitogen-activated protein kinase (MAPK)-activating kinase (MEK) inhibitor PD98059, reversed the IGF-1-induced effects observed on eIF-4E/4G assembly and phosphorylation status of 4E-BP1, eIF-4E, and eIF-4G. Drug discovery for amyotrophic lateral sclerosis (ALS) has experienced a surge in clinical studies and remarkable preclinical milestones utilizing a variety of mutant superoxide dismutase 1 model systems. Cycle detection, which does not identify individual episodes, recorded LH and FSH episode frequencies similar to those detected by the more stringent method of visual appraisal. Cytochrome P450s are found associated with membranes of endoplasmic reticulum where they catalyse the oxidation and biotransformation of a wide range of substances. Our results provide new information about a subclass of regionally expressed genes in the cortical plate at the late embryonic stage, which may help understand the molecular mechanisms of neocortical arealization. Teleradiology increases the ability of radiologists to provide service to remote and underserved locations as well as coverage at times when direct reading of images is not possible. After the NGF administration, a significant reversion of these functional changes was observed. HBV-DNA levels predict overall mortality in HIV/HBV coinfected individuals.

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On the other hand, the rate of extracellular PN-II accumulation markedly increased after long-term serum-free maintenance of the confluent culture. Analyses assessed the predictive utility of various risk and protective factors, normative influences, demographic variables, and marijuana-related attitudes, intentions, and behaviors on campaign message exposure. Among the European-identified loci that are transferable to individuals of African ancestry, allelic heterogeneity as well as differential linkage disequilibrium and risk allele frequencies pose challenges and opportunities for fine mapping and identification of causal variant(s) by trans-ancestry meta-analysis. Data from previous and present studies support a hypothesis that a change in soleus activity elicits PE catabolism, changes in cytosolic and muscular calcium, in calcium-dependent phospholipase activity, in PG biosynthesis, and in soleus size. Changes in PTCA in candidates for coronary artery bypass grafting. Service increment for teaching (SIFT): a review of its origins, development and current role in supporting undergraduate medical education in England and Wales.

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Pathophysiological processes involved in schizophrenia appear to act primarily on general abilities required in all tasks rather than on specific abilities within different memory domains and modalities. The technique provided complete forefoot anaesthesia, and was considered easier and less cumbersome to perform. There are still many Oncomelania snails that inhabit the Kofu Basin, Yamanashi Prefecture, Japan, which had been declared free of schistosomiasis japonica. Time spent walking was associated with a reduced risk for all-cause mortality, especially among nonsmoking men and women. The membrane attack complex of complement induces caspase activation and apoptosis. To describe the clinical course and treatment of an infant with acute pulmonary toxicity following intralesional administration of bleomycin for a lymphovenous malformation. SABA reliever use is a predictor of short- and long-term exacerbation risk in moderate-to-very-severe COPD patients with a history of exacerbations receiving budesonide/formoterol or formoterol. In the following six months specific chemotherapy had encouraging effects on the bypassed area. In Experiment 2, anagrams that when unscrambled formed high-imagery words were compared to those that formed low-imagery words.

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