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Perilox (Metronidazole)
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Perilox

Perilox is an antibiotic and antiprotozoal medication. It is used either alone or with other antibiotics to treat pelvic inflammatory disease, endocarditis, and bacterial vaginosis. It is effective for dracunculiasis, giardiasis, trichomoniasis, and amebiasis.

Other names for this medication:
Amebidal, Amevan, Aminidazole, Amobin, Amodis, Amotein, Amotrex, Anaerobex, Aristogyl, Clont, Dazotron, Elyzol, Emedal, Entizol, Flagystatin, Flazol, Ginerella, Gynomix, Kilpro, Litagyl, Medamet, Metazol, Metrajil, Metrazol, Metren, Metrocream, Metrofusin, Metrolag, Metronidazole, Metrovax, Metrozol, Nidagel, Nipazol, Orogyl, Otrozol, Patryl, Perilox, Promuba, Protogyl, Riazole, Robaz, Rosalox, Rozacrme, Rozamet, Suanatem, Torgyl, Trichodazol, Vagilen

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Also known as: Metronidazole

Description

Perilox (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Perilox is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.

Dosage

The dosage regimen should be individualized. Single-dose treatment can assure compliance, especially if administered under supervision, in those patients who cannot be relied on to con- tinue the seven-day regimen. A seven-day course of treatment may minimize reinfection by pro- tecting the patient long enough for the sexual con- tacts to obtain appropriate treatment. Further, some patients may tolerate one treatment regi- men better than the other.

Overdose

Single oral doses of Perilox, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Perilox has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Perilox overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.

Storage

Store below 77 degrees F (25 degrees C) and protect from light.

Side effects

The most common side effects associated with Perilox are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Metronidazole is mainly metabolised by hepatic oxidation. Substantial impairment of Metronidazole clearance may occur in the presence of advanced hepatic insufficiency. The risk/benefit ratio of using Metronidazole to treat trichomoniasis in such patients should be carefully considered. Plasma levels of Metronidazole should be closely monitored.

Cases of severe hepatotoxicity/acute hepatic failure, including cases with a fatal outcome with very rapid onset after treatment initiation in patients with Cockayne syndrome have been reported with products containing metronidazole for systemic use. In this population, metronidazole should therefore be used after careful benefit-risk assessment and only if no alternative treatment is available. Liver function tests must be performed just prior to the start of therapy, throughout and after end of treatment until liver function is within normal ranges, or until the baseline values are reached. If the liver function tests become markedly elevated during treatment, the drug should be discontinued.

Patients with Cockayne syndrome should be advised to immediately report any symptoms of potential liver injury to their physician and stop taking metronidazole.

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Primary angle-closure glaucoma (PACG) is a major cause of visual morbidity in East Asia. We hypothesized that the beneficial effects of heparin-coated circuits might be seen in patients who had cardiac reoperations. Continued investigation of predictors for generating savings is needed to inform future shared savings models. More time for research in the university clinics is also needed. Their recovery is impacted by what goes on inside the office, in treatment, as well as by involvement outside the office, in 12-step programs as Alcoholics Anonymous (AA). We developed a fast and robust system to capture the location of sample vials being placed in storage that allows the laboratories the flexibility to use sample containers of varying dimensions. Hypothermia, hyperthermia, and other systemic factors in status epilepticus. A minimally invasive surgical technique, ETAR has enabled much progress to be made in the development of local treatment strategies for rectal neoplasia. The optimized conditions have allowed a fourfold increase of the ligand-binding active form of the receptor, whereas the total expression level determined by EGFP fluorescence measurements was not modified.

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Many mucosal pathogens, including Neisseria gonorrhoeae, produce proteases that cleave immunoglobulin A (IgA), the predominant immunoglobulin class produced at mucosal surfaces. Intestinal absorption and unmediated permeation of sugars in post-infective tropical malabsorption (tropical sprue). Anterior cingulate dysfunction in presenile dementia due to progressive supranuclear palsy. Mapuche individuals have higher levels of HDL cholesterol a better total cholesterol/HDL cholesterol ratio and lower frequency of smoking than non aboriginal Chileans subjects. In the experiment performed on 108 test and 28 control dogs, by means of injection and histological methods, the effect of arteriovenous fistula on the cardiac microcirculatory bed has been studied. Influence of mung bean severe mosaic virus infection on growth, nodulation, nodular physiology and nitrogen fixation of mung bean.

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These studies, along with mechanistic data derived from cell culture studies, provide compelling evidence that alpha(v)beta3 integrins are involved in vascular repair processes. Clinical study of allantoinic derivatives of aluminnum in gastroduodenal disorders. The subjects were studied both in a random sampling and in a controlled manner, fasting and 2 hours after receiving the drug. Although the patient data with 1 and 2 cathodes did not differ significantly, energy consumption was significantly higher when 3 cathodes were used instead of 1 or 2 cathodes. Protein quantity and quality in term and preterm infants: effects on urine creatinine and expression of amino acid excretion data. The two hypotheses each have evidence that either supports or contradicts them, but consensus has failed to emerge. In this paper, the second in a two part series on focus groups, a comprehensive overview of the literature concerning the interviewing process, methodology and analysis is provided. First, the wastes were chemically and physically characterized and also tested primarily taking into account the requirements for aggregates in bituminous mixtures. It is suggestive in the present study that inactivation patterns of p16/INK4A were mainly homozygous deletion, promoter methylation rather than point mutation in oral squamous cancer cell lines, so treatment modalities of oral squamous cell carcinoma should be focused on these types of inactivation. Some clinical and laboratory parameters including IgA-antigliadin and IgG-antigliadin antibodies were evaluated to predict their usefulness in selecting IgA-deficient patients for intestinal biopsy.

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Elderly people with hypothalamic-pituitary disease and untreated GH deficiency: clinical outcome, body composition, lipid profiles and quality of life after 2 years compared to controls. Does visual augmented feedback reduce local dynamic stability while walking?. A study on the extent of 18O incorporation into various hydroxy-eicosatetraenoic acids, thromboxane B2 and 2,3-dinor-thromboxane B2 by base-catalysed hydrolysis of their methyl ester derivatives is presented. Methylglyoxal caused dose-dependent increases in basal and Staphylococcus aureus-stimulated H(2)O(2) production and basal and formyl-methionyl-leucyl-phenylalanine-stimulated O(-)(2) production. Correlating with its effects in various tumor models, CUDC-305 induces degradation of receptor tyrosine kinases and downstream signaling molecules of the PI3K/AKT and RAF/MEK/ERK pathways simultaneously, with concurrent induction of apoptosis in vivo. We have investigated the production of Epo in response to three stimuli, hypoxia, cobalt chloride, and the iron chelator desferrioxamine, in Hep3B cells. Morulae of Ehrlichicia canis were found in peripheral blood smears from all experimental animals. Ephedra-containing dietary supplements in the US versus ephedra as a Chinese medicine. A quasi-experimental cohort design with medical student self-ratings as the dependent variable. In critically ill patients with HIT, the incidence of thromboembolic complications and hemorrhagic complications was remarkably high.

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Assessing quality of life in pediatric epilepsy is especially important because children are in critical periods of development during which many cognitive and social skills are being learned. In summary, through tandem functional screens, we identified the Tpl2/AP-1 signaling transduction pathway as a positive regulator of MHV-68 lytic replication. Protein and RNA synthesis inhibitors prevented the death of neurons. Relationship between expression of cell surface hydrophobicity protein 1 (CSH1p) and surface hydrophobicity properties of Candida dubliniensis. In vitro deposition of fluticasone aerosol from a metered-dose inhaler with and without two common valved holding chambers. A cupric reductase activity is also increased in copper-deficient compared with copper-sufficient cells. Finally, 3-(4-(4-fluorophenyl)-5-(4-aminosulfonyl-3-fluorophenyl)-oxazole-2-yl) propanoic acid (NC-2142), the best candidate, was selected for synthesis and bioassay based on the screening result. Immunoblot and immunohistochemical analysis of pKC7-transfected and MV-infected cells showed that increased transcription led to an increase in p53 protein.

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