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Noritate (Metronidazole)

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Flagyl is an oral antiprotozoal and antibacterial. It is thought to work by entering the bacterial cell, acting on some components of the cell, and destroying the bacteria. Treating certain infections caused by bacteria or amoebas. It may also be used for other conditions as determined by your doctor.

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Aminidazole, Amobin, Anegyn, Anerobia, Bemetrazole, Biozyl, Fladex, Flanizol, Fortagyl, Gynoplix, Metral, Metren, Metrocream, Metronidazolum, Minegyl, Nipazol, Novazole, Protozol, Rhodogil, Rupezol, Stomorgyl, Suanatem, Trichex, Trichomonacid, Trichozole, Triconex

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Also known as: Metronidazole


Noritate (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Noritate is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.


In elderly patients, the pharmacokinetics of metro- nidazole may be altered, and, therefore, monitor- ing of serum levels may be necessary to adjust the metronidazole dosage accordingly.


Single oral doses of Noritate, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Noritate has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Noritate overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

Side effects

The most common side effects associated with Noritate are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


As a rule, the usual duration of therapy with i.v Metronidazole or other imidazole derivatives is usually less than 10 days. This period may only be exceeded in individual cases after a very strict benefit-risk assessment. Only in the rarest possible case should the treatment be repeated. Limiting the duration of treatment is necessary because damage to human germ cells cannot be excluded.

Intensive or prolonged Metronidazole therapy should be conducted only under conditions of close surveillance for clinical and biological effects and under specialist direction. If prolonged therapy is required, the physician should bear in mind the possibility of peripheral neuropathy or leucopenia. Both effects are usually reversible.

In case of prolonged treatment, occurrence of undesirable effects such as paraesthesia, ataxia, dizziness and convulsive crises should be checked. High dose regimes have been associated with transient epileptiform seizures.

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Evaluation of light transmission and distribution materials for Lunar and Martian bioregenerative life support. The amorphous PEGDME2000 exhibits high stability, which is consistent with the recent experiment results and can be ascribed to a combination of two factors, that is, a high thermodynamic driving force for amorphization and a relatively low molecular mobility. The possibility that serotoninergic mechanisms control the reinforcing properties of d-amphetamine and morphine was investigated in rats, using zimelidine, a potent and selective serotonin uptake blocker and the conditioned place preference test design. Left ventricular (LV) remodeling (LVR) after an acute myocardial infarction (AMI) has important clinical implications. In Experiment 1 subjects had to press one of two lateralized keys in response to one of two stimuli (a rectangle or a square). Degree of competition at feeding differentially affects behavior and performance of group-housed growing-finishing pigs of different relative weights. The French paradox has been associated with regular intake of red wine, which is enriched with flavonoids. This finding suggests that the mutation patterns of HCV and HGV are similar to the patterns of spontaneous substitution mutations of human genes, implying that nucleotide analogues which are effective against HCV and HGV may have a side effect on the normal cells of humans. The purpose of this study was to determine whether complications are actually higher in patients of advanced age.

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We have observed the presence of Gdnf transcripts in the gastrointestinal tract of adult mice, and its early up-regulation after inflammation. Our review suggests that extended field radiation has minimal or no impact on the natural history of prostatic carcinoma in patients with positive nodes. Hypertonic saline is emerging as a potentially effective single osmotic agent for control of acute elevations in intracranial pressure (ICP) caused by severe traumatic brain injury. Fruit was related to a reduced RR of cancers of the myambutol brand upper digestive tract, stomach and urinary tract. Lack of erythroid characteristics in Ia-positive leukemia cell lines induced by Friend murine leukemia virus: brief communication. The spliceosome is a ribonucleoprotein machine that removes introns from pre-mRNA in a two-step reaction. To optimize the serum bactericidal assay (SBA), detect and analyze the bactericidal antibody level against Neisseria meningitidis serogroup C strains after divalent polysaccharide (A plus C) vaccine immunization. The interpersonal variability was such that only broad generalizations are possible. These results and the proposed insertion sequence-mediated tdh transfer mechanism suggest that the tdh gene may have been maintained stably in V. Marked hypervascularity and early arteriovenous shunting with portal vein filling in chronic relapsing pancreatitis.

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Sensitizing glioma cells to cisplatin by abrogating the p53 response with antisense oligonucleotides. There has been no systematic evaluation of the use of demeclocycline for the treatment of HN secondary to SIADH to date. Four cases of fetal rhabdomyoma and naevoid basal cell carcinoma syndrome have been previously reported. We suggest that this effect is due to the diffusion of hydrogen, whose diffusivity remains significant even at liquid nitrogen temperature over the length scales and time scales relevant to transmission electron microscopy analysis of thin specimens. Prognostic value of a new quantitative D-dimer test in critically ill patients 24 and 48 h following admission to the intensive care unit. We found that ethanol-exposed adolescent offspring preferred the closed arms over the open arms in the elevated plus maze and displayed lower head dipping activity than controls. The influence of subinhibitory cefpodoxime 500 mg concentrations (1/2, 1/4, 1/8, 1/16 and 1/32 x MIC) of ceftazidime, ciprofloxacin and azithromycin on the morphology and adherence of 29 wild-type P-fimbriated strains of Escherichia coli was studied. Liver and kidney from control rats were assayed and values of 7 and 67 micrograms/g were measured in the two tissues, respectively.

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