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Negazole (Metronidazole)

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Also known as: Metronidazole


Negazole (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Negazole is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.


In elderly patients, the pharmacokinetics of metro- nidazole may be altered, and, therefore, monitor- ing of serum levels may be necessary to adjust the metronidazole dosage accordingly.


Single oral doses of Negazole, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Negazole has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Negazole overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.


Store at room temperature below 25 degrees C (77 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Negazole are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Metronidazole should be used with caution in patients with active disease of the Central Nervous System. The treatment should be withdrawn in case of ataxia, dizziness, or confusion. The risk of aggravation of the neurological state should be considered in patients suffering from severe central and peripheral neurological diseases, fixed or progressive paraesthesia and epilepsy. Caution is required in patients with active disease of the central nervous system except for brain abscess.

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Trypanothione reductase from the human parasite Entamoeba histolytica: a new drug target. Among ten families with de novo 21/21 translocation Down syndrome (tDS), four were informative, according to the studies of structural variants of chromosome 21, about the origin of the aberrant chromosome. To investigate the roles of cytokines like interleukin-6 (IL-6), tumor necrosis factor (TNF) and local immune reaction in proliferative vitreoretinopathy (PVR). The light-enhanced startle paradigm as a putative animal model for anxiety: effects of chlordiazepoxide, flesinoxan and fluvoxamine. The long term energetic cost of the use of these stimulants and the concomitant potential for a reduction in growth rate of cultured decapod crustaceans, which is fundamental to the success of commercial aquaculture, is identified and discussed. We present a case report of a woman treated for breast cancer, with suspicion of recurrent disease due to increase of tumor markers. Also, Gna1 mutants were unable to sporulate, showed an albino phenotype, and secreted one or more brown pigments into growth media. The vitronectin receptor (integrin alphavbeta3) and TF have recently been found to play a key role in apoptotic cell death and vascular endothelial cell injury. A raised parathyroid hormone level (secondary hyperparathyroidism) is also a majorrisk factor for cardiovascular disease and is associated with increased hypertension and resistance to the treatment of CKD-associated anaemia. We hypothesize that Cerebrolysin might exert this effect, in part, by regulating the expression of amyloid precursor protein (APP).

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A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain. The expression of fatty acid synthase (FAS), a key lipogenic enzyme and potential target for antineoplastic therapy, was analyzed in 87 frozen needle biopsies of prostate cancer using a highly sensitive immunohistochemical detection technique (Envision). Modulation of error-sensitivity during a prism adaptation task in people with cerebellar degeneration. The effect of rebreathing CO2 on ventilation and diaphragmatic electromyography in newborn infants. Contrast-enhanced ultrasound detection and treatment guidance in a renal transplant patient with renal cell carcinoma.

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The purpose of this work is to describe the role of radiotherapy in endometrial carcinoma. Contribution to the study of the arterial nutrition of the cervical spinal cord. Concanavalin A induced suppression of lymphocyte proliferation in chronic liver disease. Andrographolide and kalmegh (Andrographis paniculata) extract: effect on intestinal brush-border membrane-bound hydrolases. These included seven patients with fibrosing alveolitis, six with silicosis, two with hypersensitivity pneumonitis, three with lymphangitic spread of tumor, two with sarcoidosis, one with rheumatoid lung disease, and two with neurofibromatosis.

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UV-A induces persistent genomic instability in human keratinocytes through an oxidative stress mechanism. The molecular switch mechanism underlying the fate decision of apoptosis in mammalian cells has been intensively studied by mathematical modeling. Children with normal neurologic examination results and normal cranial CT scan results after immediate posttraumatic seizures are at low risk for further short-term complications that require immediate hospitalization. The conformational and lipid binding properties of several calcitonin analogs were compared. To determine the efficacy of the invasive Wada test in determining language dominance, and to validate the functional transcranial Doppler sonography (fTCD) examination in patients. A proposed integration of STD treatment into general outpatient clinics and better implementation of syndromic management and health education should improve STD case management at primary level in Mozambique. These data provide evidence that Pristimerin has strong potential for development as a novel agent against prostate bone metastasis by suppressing PC-3 stem cell characteristics and VEGF-induced vasculogenesis of BM-EPCs.

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We developed computerized algorithms to segment and quantify nuclear and ductal parameters that characterize breast architectural features. To explore TN-C isoform variability in mouse brain, the alternatively spliced region of TN-C mRNAs was examined by the reverse transcription-polymerase chain reaction technique. It is found that in sorbitol the dynamics of the whole molecule contributes equally to the beta process, while in glycerol the hydrogen bond forming OH groups remain rather rigid compared to the hydrogens bonded to the carbon skeleton. Should you ask a fisherman or a biologist?: Developmental shifts in ways of clustering knowledge. A case-control study of patients ranging in age from 52 to 88 years was done to determine any possible relationship between health factors and senile macular degeneration. The role of methylenetetrahydrofolate reductase gene polymorphism is less clear.

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ATP inhibition was observed only at very high concentrations of ATP. To examine for an association of elevated lower-limb vibration perception threshold (VPT) with NAFLD fibrosis. The purpose of this study was to determine the value of screening transvaginal ultrasonography for the evaluation of endometrial abnormalities in women with postmenopausal bleeding. pneumoniae by different types of bactericidal antibiotics were conducted to determine the existence of multidrug-tolerant K. In order to promote innovative research in asthma therapies, the National Heart, Lung and Blood Institute created the Childhood Asthma Research and Education Network in 1999. Among these, isoferulic acid was the prominent active principle in CRE, responsible for the observed inhibition of IL-6, TNF-alpha, and IFN-gamma, but not for IL-8 stimulation. Tubal infertility in the Gambia: chlamydial and gonococcal serology in women with tubal occlusion compared with pregnant controls. A case of a gun-shot wound with a bullet of non-lethal action is described.

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The next generation of prognostic models for DLBCL aims to more accurately stratify patients for novel therapies and risk-adapted treatment strategies. The method employs a primary fluorescein-conjugated mouse monoclonal antibody directed against pimonidazole protein adducts that are created in hypoxic tissues and a secondary mouse anti-fluorescein antibody that is conjugated to horseradish peroxidase. Sleep in obsessive-compulsive disorder: a systematic review and meta-analysis. These data indicate that the arterial stiffening that is related to aging/menopause is not substantially affected by long-term estrogen therapy. We successfully performed expression profiling experiments on the Atlas Human cDNA arrays which contain 1176 human genes. This review will first summarize and discuss the technical problems encountered with several representative in vitro chemosensitivity tests on clinical specimens, including retinoblastoma. It is a clinically useful procedure and has the following benefits. The expression of hK6 in ovarian cancer was higher than that in benign and borderline ovarian neoplasms. Age and level of physical activity did not alter the T2 response to running. Chemical communication is essential for levaquin intravenous dosage the coordination of complex organisation in ant societies.

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Mosquitoes of the Anopheles bancroftii group collected from Northern Australia and Papua New Guinea (PNG) were investigated for sequence variation within the ribosomal DNA ITS2. Application of this method to the Activated Protein C and factor VII Gla-domains revealed surface regions involved in EPCR and plasma membrane binding, consistent with known experimental results. Also, across therapy procedures, extended therapy generated more response persistence in escape extinction than did abbreviated therapy. Several white matter tracts in the brain cannot be identified on MR studies because they are indistinguishable from the surrounding white matter. Cardiovascular and metabolic alterations in mice lacking both beta1- and beta2-adrenergic receptors. Upon incorporation of these principles into our latest Precision Decomposition system for sEMG signals, 20 to 30 motor unit action potential trains (MUAPTs) were decomposed per experimental sEMG signal from isometric contractions with trapezoidal force profiles.

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Anterior subcutaneous or submuscular transposition of the ulnar nerve are recommended treatments for the cubital tunnel syndrome. Rearrangements of integral membrane components during in vitro aging of sheep erythrocyte membranes. beta-Carotene and canthaxanthin in a dose of 75--250 mg a day by mouth reduced the symptons of exposure to the sun in all 7 treated patients with erythrohepatic protoporphyria (EPP), in 15 of 18 with polymorphous light eruptions (PMLE) and in 3 of 4 with lupus erythematodes discoides. Data were obtained on VT and in 1 cardiac cycle stored digitally (1C). We described laboratory data on samples and surveillance data from case reports for LGV from 2004-2010. A social marketing theory-based diet-education program for women ages 54 to 83 years improved dietary status. Importance of the auxotyping of Neisseria gonorrhoeae for evaluating gonorrhea therapy studies. However, new results now bolster the hypothesis that there is a causal relationship between variant glycosylation and altered integrin activity.

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Purification and properties of an inactivator of glucosamine-6-phosphate synthetase from rat submandibular gland. Modes of cell death in the pupal perivisceral fat body tissue of the silkworm Bombyx mori L. Patients who remained free of adverse cardiac events six weeks after myocardial infarction had stress and rest 201TI imaging and exercise electrocardiography and were followed up for 8-32 months. Different phenotypes of Charcot-Marie-Tooth disease caused by mutations in the zithromax suspension buvable same gene. On the problem of the pathogenesis and therapy of dumping syndrome. In recent years, the field of remote sensing of birds and insects in the atmosphere (the aerial fauna) has advanced considerably, and modern electro-optic methods now allow the assessment of the abundance and fluxes of pests and beneficials on a landscape scale. Synthesis of 6,6-dicarboxy-3,4-methano-L-proline, a new constrained glutamate analog endowed with neuroprotective properties.

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