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Metrozin (Metronidazole)
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Metrozin

Metrozin is an antibiotic and antiprotozoal medication. It is used either alone or with other antibiotics to treat pelvic inflammatory disease, endocarditis, and bacterial vaginosis. It is effective for dracunculiasis, giardiasis, trichomoniasis, and amebiasis.

Other names for this medication:
Collazole, Cresac, Deflamon, Entizol, Fladystin, Flagystatin, Flanizol, Ginkan, Metazole, Metral, Metrin, Metris, Metrocev, Metrocreme, Metrogyl, Metronid, Metronidazolum, Metronour, Metrosil, Metroson, Metrozole, Minegyl, Mtrocol, Nidazyl, Polibiotic, Protogyl, Repligen, Rhodogil, Rosaced, Rovamet, Taremis, Tismazol, Trichomonacid, Triconex, Unigyl, Vertisal

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Also known as: Metronidazole

Description

Metrozin (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Metrozin is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.

Dosage

The usual adult oral dosage is 7.5 mg/kg every six hours (approx. 500 mg for a 70-kg adult). A maximum of 4 g should not be exceeded during a 24-hour period.

The usual duration of therapy is 7 to 10 days; however, infections of the bone and joint, lower respiratory tract, and endocardium may require longer treatment.

Patients with severe hepatic disease metabolize metronidazole slowly, with resultant accumulation.

Overdose

In cases of overdose in adults, the clinical symptoms are usually limited to nausea, vomiting, ataxia and slight disorientation. In a preterm newborn, no clinical or biological sign of toxicity developed.

There is no specific treatment for Metrozin overdose, Metrozin infusion should be discontinued. Patients should be treated symptomatically.

Storage

Store Metrozin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Metrozin out of the reach of children and away from pets.

Side effects

The most common side effects associated with Metrozin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Interaction with Alcohol. Use of oral metronidazole is associated with a disulfiram-like reaction to alcohol, including abdominal cramps, nausea, vomiting, headaches, and flushing. Discontinue consumption of alcohol or products containing propylene glycol during and for at least three days after therapy with metronidazole.

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The positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus is mistranslated in a bldA mutant. Anatoxin-a elicits an increase in peroxidase and glutathione S-transferase activity in aquatic plants. Based on this information, we have proposed a model for CS1-pilus assembly which is very similar to the model for polymerization of the PapA pilin of uropathogenic E. Effect of adaptation to brief stress exposure on the realization of the stress reaction, impairment of metabolism and myocardial contraction caused by prolonged emotional-pain stress. 5 alpha-Reductase activity was found only in particulate subcellular fractions of a homogenate of epidermal keratinocytes when assayed with tritium-labeled progesterone as the substrate and NADPH as the cofactor. With standard perfusion chambers, the duration of a typical experiment is limited to one cell generation time.

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