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Metronidazolum (Metronidazole)

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Metronidazolum is used to treat bacterial infections in different areas of the body. The extended-release tablets are used to treat women with vaginal infections (bacterial vaginosis).

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Also known as: Metronidazole


Metronidazolum (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Metronidazolum is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.


Pregnant patients should not be treated during the first trimester. In pregnant patients in whom alternative treatment has been inadequate, the one-day course of therapy should not be used, as it results in higher serum levels which can reach the fetal circulation


Single oral doses of Metronidazolum, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Metronidazolum has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Metronidazolum overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.


Store below 77 degrees F (25 degrees C) and protect from light.

Side effects

The most common side effects associated with Metronidazolum are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


As a rule, the usual duration of therapy with i.v Metronidazole or other imidazole derivatives is usually less than 10 days. This period may only be exceeded in individual cases after a very strict benefit-risk assessment. Only in the rarest possible case should the treatment be repeated. Limiting the duration of treatment is necessary because damage to human germ cells cannot be excluded.

Intensive or prolonged Metronidazole therapy should be conducted only under conditions of close surveillance for clinical and biological effects and under specialist direction. If prolonged therapy is required, the physician should bear in mind the possibility of peripheral neuropathy or leucopenia. Both effects are usually reversible.

In case of prolonged treatment, occurrence of undesirable effects such as paraesthesia, ataxia, dizziness and convulsive crises should be checked. High dose regimes have been associated with transient epileptiform seizures.

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aureus, oxacillin-resistant, coagulase-negative staphylococci, and penicillin-resistant viridans group streptococci. Both thrombospondins were digested with either trypsin or thermolysin, in the presence or absence of calcium, then injected onto a Superose 12 gel filtration column. The researcher could not be blinded due to the role they played in the trial organisation. The marked increase of coronary angioplasty procedures worldwide is based on two facts. Dendrimers as drug delivery vehicles: non-covalent interactions of bioactive compounds with dendrimers. This method permits the determination of Km and Vmax even if the presence of the enzyme (or any impurity in the solutions used) influences the rate of substrate decomposition. Dose--response relationships to apomorphine-induced vomiting and stereotyped running behaviour have been determined in dogs before, and up to 24 and 28 days respectively, after daily oral treatment with 2.5 mg/kg of teflutixol or 12 days. A subgroup of the Kenyon cells shows distinct but weaker levels of glutamate-immunoreactivity.

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Echocardiographic assessments of left atrial strain and volume in healthy patients and patients with mitral valvular heart disease by tissue Doppler imaging and 3-dimensional echocardiography. In a prospective study the echocardiography (M-mode-and two dimensional methodology) as well as the electrocardiography were tested in 40 patients with chronic bronchopulmonary diseases and suspicion of chronic cor pulmonale concerning their statements about right-ventricular hypertrophy and dilatation of the right-sided cavities of the heart. Areas undergoing structural changes showed localized foci of high dextran accessibility. Postoperative pain was evaluated every 6 hours by a visual analog scale for 3 days. A unique strategy for pediatric community health nursing for ADN students. We also had difficulties in diagnosis and treatment in one of our patients with a multicentric epitheloid hemangioendothelioma involving the pelvis, left femur, and left tibia. Prevention of diabetes-induced myocardial dysfunction in rats by methyl palmoxirate and triiodothyronine treatment. Mackinawite (FeS) and greigite (Fe(3)S(4)) were the dominant iron sulfide phases formed in sulfate-reducing bacterial cultures.

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There were significant variations in MI and LI in all organs and there were also significant differences between organs in respect of the pattern of variation. Nocardia thailandica is a rare pathogen related to Nocardia asteroides, Nocardia neocaledoniensis, and Nocardia caishijiensis that, since its original description in 2004, has only been reported to cause wound and ocular infections in humans. With intact carotid chemoreflexes, lowered PaO2 caused hyperventilation, which was progressively intensified with the degree of hypoxia, regardless of whether the alveolar PCO2 was uncontrolled or kept constant at the hyperoxic control. Enhanced fluorescence emission accompanied by no significant changes in excited state lifetimes of fluorophores with emission wavelengths in the visible blue-to-red spectral range near-to zinc nanostructured films were observed, implying that MEF from zinc nanostructured films is mostly due to an electric field enhancement effect. The change of the left DLPFC activation suggests that antidepressants are associated with a more balanced allocation of cognitive control across self-referential and non-self-referential processes. Strains non producing ESBL were cultivated in concentrations of ceftazidime equal to MICx2 and MICx4. A high-pressure liquid chromatographic-tandem mass spectrometric method for the determination of ethambutol in human plasma, bronchoalveolar lavage fluid, and alveolar cells. The objective of the present study was to compare the total intraoperative radiation dose and assess the resultant image quality for O-arm-assisted pedicle screw insertion, among 3 protocols: default (manufacturer recommended), institutional (reduced dose utilized in our institution), and pediatric (new protocol with lowest dose). Detection of illicit drugs in oral fluid from drivers as biomarker for drugs in blood. NCC-melb4 cells provide a model to study the specific stage of differentiation and proliferation of melanocytes.

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Sparfloxacin as alternative treatment to standard therapy for community-acquired bacteremic pneumococcal pneumonia. Nonetheless, ciglitazone failed to enhance the PAR1-triggered phosphorylation of ERK and p38MAPK. Currently available methods for analyzing the structural properties of neural tissue are limited by the frequency at which data can be collected and by the need to sacrifice the specimen to correlate histology with other data. In a second series of experiments, the activity of the compounds was investigated on ovarian proteins. These results need to be confirmed in larger scale prospective studies. The comparative study showed that the newly proposed computationally simple optimum power normal approximation method works best even for small sample sizes. We investigated resting energy expenditure (REE) in 473 patients with biopsy-proven liver cirrhosis. Perceived discrimination was measured with a nine-item scale developed by Williams, Yu, Jackson, and Anderson (1997). Under baseline conditions, aggressive behavior (responding on the mirror) occurred at the onset of each extinction period.

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In testing sera with or without antibody to Brucella abortus a very high correlation existed between same day tests and tests performed over several days as well as with data on the same sera obtained by an enzyme immunoassay in a microtiter format. Uterine implantation and subsequent vascularization increase oxygen exposure of the developing embryo, thereby altering the intracellular reduction-oxidation status. To further reduce the incidence of haemorrhagic complications during stereotactic biopsy, the use of a microvascular Doppler system is proposed. The medical and surgical management of patients with multiple muscular ventricular septal defects (VSDs) is associated with morbidity and mortality. Another type of cell had scanty cytoplasm and a round to oval nucleus with small but prominent nucleoli. Monitoring the hydrolysis of toxic organophosphonate nerve agents in aqueous buffer and in bicontinuous microemulsions by use of diisopropyl fluorophosphatase (DFPase) with (1)H- (31)P HSQC NMR spectroscopy. Tuberous sclerosis was the commonest disease, predisposing to calcifications that were essentially nodular in type and bilaterally periventricular in distribution. High plasma levels of proinflammatory molecules within 24 hours of intracerebral hemorrhage onset are correlated with the magnitude of the subsequent perihematoma brain edema, whereas poor neurologic outcome and the volume of the residual cavity are related to increased plasma glutamate concentrations. Parental style is a critical factor in the development of food preferences. Some observations, both structural and functional, suggest that more attention needs to be paid to conformational changes that occur before the channel opens.

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Electrophoretic separation on cellulose acetate and on paper of human hemoglobin, canine hemoglobin and of their recombination products. The inhibitory effect of NAAG on NMDARs and its enhanced function in acidic conditions make NAAG a prime therapeutic agent for the treatment of ischemic events. The dependence of electrophysiological derangements on accumulation of endogenous long-chain acyl carnitine in hypoxic neonatal rat myocytes. Micrometer-sized microcapsules collapse upon exposure to ultrasound. Renal function status in patients with primary osteoporosis (type 2). It has a net sample size of 500 randomly selected 18-45-year-old adults living in Mannheim, Germany. Conceptually, the results point to CD56(dim) NK cells as an important source of cytokines and chemokines upon recognition of aberrant cells, producing graded responses depending on the multiplicity of activating receptors engaged. Addition of exogenous GDNF to the culture medium decreased the number of stem cells present at 1 wk of coculture, but enhanced stem cell maintenance at 2 wk compared to cultures without added GDNF. Protective effects of analogs of luteinizing hormone-releasing hormone against x-radiation-induced testicular damage in rats.

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Compensatory mechanisms are associated with contralateral cortical recruitment of the lateral premotor circuitry. Phenobarbital and dexamethasone also induced both the mRNA and protein of CYP2Bs and CYP3As, respectively, in adipose tissue, although significant interindividual differences were observed. In systems with long-range elastic forces the description of the nucleation process can be quite subtle due to the presence of bulk and surface elastic compatibility constraints. Routine Assessment of Patient Index Data 3 (RAPID3) on a Multidimensional Health Assessment Questionnaire (MDHAQ cleocin pediatric dosing ) is feasible and informative in many rheumatic diseases. Postcontrast fluid-attenuated inversion recovery (FLAIR) imaging effectively depicts parenchymal and leptomeningeal metastases, as reported in limited patient groups. Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat.

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Pre-eclampsia presenting as hyponatremia: an uncommon presentation of pre-eclampsia in a twin pregnancy - a case report and review of the literature. In a first cycle, (S)-malyl-CoA is formed from acetyl-CoA and 2 molecules of bicarbonate. Despite this overall consistency, ethnic diversity in the pattern and strength of linkage disequilibrium certainly exists and can help to appreciably reduce potential causal variants after GWA studies. Results indicated that labor and delivery in the breech position had a morbidity and mortality rate far greater than could be attributed to prematurity alone. A significant dose-response relation corresponding to the expected rank-order efficacy was revealed. The recovery of hematopoietic function in short term chemotherapy group and long term chemotherapy, with or without ABMSC infusion (1.1 - 8.7) x 10(8) post chemotherapy groups was observed. Plasma concentrations of bupivacaine remained small during the study period. There was only one regulatory mechanism, corresponding to the slow component seen earlier.

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Reduced number of hip fractures is the most obvious benefit of the Falun project. Assessing workplace chemical exposures: the role of exposure monitoring. Drain-related complications include (1) those possibly benefiting from drainage (leakage, intra-abdominal infection, bleeding) and (2) those possibly caused by drainage (wound infection or hernia, intestinal obstruction, fistula). Traditional characterization techniques such as cyclic voltammetry and electrochemical impedance spectroscopy cover a small fraction of the characterization framework needed for ensuring the safety and performance of electrodes designed for long-term implants. Further well-designed case-control studies with larger sample size and more ethnic groups are needed to confirm these conclusions. An unsupervised, levaquin dose cap home exercise program is the least effective way to deliver exercise to people with PD, and individual and group exercises have differing benefits.

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Reward-seeking behaviors depend critically on dopamine signaling--dopamine neurons encode reward-related information by switching from tonic to phasic (burst-like) activity. It is concluded that results of previous studies depended on the sample mix of abusers, moderate drinkers and abstainers. A total of thirty-six femoral condyles from 3-kilogram New Zealand White (NZW) rabbits were used during this evaluation. There was considerable agreement on priorities between the two groups with musculoskeletal disorders and stress securing the highest ranking. We investigated the effects of captopril (Cap) and L-arginine (Arg) on hypertension and cardiopulmonary function. Analysis of quartz by FT-IR in air samples of construction dust.

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