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Metazole (Metronidazole)

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Metazole is used to treat bacterial infections in different areas of the body. The extended-release tablets are used to treat women with vaginal infections (bacterial vaginosis).

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Also known as: Metronidazole


Metazole (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Metazole is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.


In elderly patients, the pharmacokinetics of metro- nidazole may be altered, and, therefore, monitor- ing of serum levels may be necessary to adjust the metronidazole dosage accordingly.


Single oral doses of Metazole, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Metazole has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Metazole overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.


Store Metazole at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Metazole out of the reach of children and away from pets.

Side effects

The most common side effects associated with Metazole are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Metronidazole is mainly metabolised by hepatic oxidation. Substantial impairment of Metronidazole clearance may occur in the presence of advanced hepatic insufficiency. The risk/benefit ratio of using Metronidazole to treat trichomoniasis in such patients should be carefully considered. Plasma levels of Metronidazole should be closely monitored.

Cases of severe hepatotoxicity/acute hepatic failure, including cases with a fatal outcome with very rapid onset after treatment initiation in patients with Cockayne syndrome have been reported with products containing metronidazole for systemic use. In this population, metronidazole should therefore be used after careful benefit-risk assessment and only if no alternative treatment is available. Liver function tests must be performed just prior to the start of therapy, throughout and after end of treatment until liver function is within normal ranges, or until the baseline values are reached. If the liver function tests become markedly elevated during treatment, the drug should be discontinued.

Patients with Cockayne syndrome should be advised to immediately report any symptoms of potential liver injury to their physician and stop taking metronidazole.

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Effects of diadenosine polyphosphates on renal function and blood pressure in anesthetized Wistar rats. During tissue modeling and remodeling, small fragments of proteins are released into the circulation, where they may be used as biomarkers for tissue turnover. There was a simultaneous increase in the maximum intra-urethral pressure from a mean of 66 mmHg to 82 mmHg. The repetitive nature of these reports suggests the need for systematic investigation. While the goal of percutaneous management of renal and ureteral calculi is stone extraction or disintegration, perforation of the renal pelvis or ureter may allow stones or stone fragments to become extruded during endourologic manipulations. pylori colonisation, suggesting that specific T-cell responses may be down-regulated by an enhanced TH2 reaction. This antibody inhibited the binding of human IgG to the Fc gamma R on U937 cells, HL-60 cells and human peripheral blood monocytes. This section of the genome includes the 18S, 5.8S and 28S genes which code for ribosomal RNA (rRNA) and which have a relatively conserved nucleotide sequence among fungi.

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Detecting the peripheral haematologic parameters and lymphocyte subsets may be helpful in the diagnosis and the differential diagnosis of CAEBV. Ketotifen did not affect the free plasma or brain levels of antiepileptics tested. Previously, using chimeric proteins, we determined that domains or residues distal to transmembrane domain 11 (amino acid 531) dictate the increased sensitivity of human SERT to imipramine. Multivariate regression analysis was performed to compare the three surgical approaches. Because of the localisation in the bottom parts of the mucosa and submucosa, a histological diagnosis is difficult to establish at endoscopic biopsies. The effects of immobilization of the right lower limb on driving performance are unknown. Of the 36 patients, 28 had a seizure disorder, while the other eight had various conditions unassociated with epilepsy. With this technique we could easily establish pure melanocyte culture.

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Chronic stimulation of anterior pituitary cell cultures with CRF leads to the secretion of lipotropin. A specific histone deacetylase, Rpd3, interacts with a variety of sequence-specific transcriptional repressors, including Mad-Max heterodimers and members of the nuclear receptor superfamily. When fluorescein isothiocyanate-labeled BSA (FITC-BSA) was used as tracer, the free and bound FITC-BSA were well separated giving definite peaks with laser induced fluorescence detection. Aminophylline partially, isoprenaline almost completely and calcium completely antagonized the negative inotropic action of guanabenz. Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation. Process evaluation of a school-based education program about organ donation and registration, and the intention for continuance. In eukaryotes, size optimality renders the diffusive transport as efficient as active transport - in this way, the cells can conserve energetic resources that would otherwise be expended in active transport.

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Due to rarity of PTCL, international collaboration is mandatory in order to study the various aspects of SCT in this patient population. Reduction in hospitalisations and emergency department visits for frail patients with heart failure: Results of the UMIPIC healthcare programme. Inhaled nitric oxide (NO) is thought to provide a noninvasive therapeutic alternative to extracorporeal membrane oxygenation (ECMO) in the treatment of persistent pulmonary hypertension of the newborn (PPHN). The data collected on this single participant show that treadmill locomotion with BWS and robotic assistance elicits a metabolic response to treadmill gaiting characterized by increased VO2, VE, HR, and caloric expenditure. We compared the expression profiles of immune-related genes between IAV-infected wild-type p53 (p53WT) and p53-deficient (p53KO) mice to gain an insight into the basis of p53-mediated antiviral response. CET was measured by both mass and isotopic assays and compared in two groups of euglycemic non-insulin-requiring IDDM PKT patients with either systemically draining allografts and persistent HI or grafts with portal vein anastomoses that were normoinsulinemic (PK-P). The role of the medial ligaments in lateral stabilization of the ankle joint: an in vitro study. There are no mortality statistics, however, and the current study used published data from these trials to estimate the disease-specific mortality in this high-risk population.

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Especially in rehabilitation, patient training is considered essential for long-term treatment success. Small renal neoplasms: diagnostic imaging, pathologic features, and clinical course. The rationale for the inhibition of ornithine decarboxylase as a cancer chemopreventive agent has been strengthened in recent years because this enzyme has been shown to be transactivated by the c-myc oncogene in certain cell/tissue types and to cooperate with the ras oncogene in malignant transformation of epithelial tissues. The effects can not be attributed to influences on locomotor, exploratory, pro- or anti-conflict behaviour, since LY294002 had no influence on elevated plus-maze behaviour. There were no significant differences, however, in high-frequency (HF) power, low-frequency (LF) power, and the LF/HF ratio between Zucker-fatty and Zucker-lean rats. Renal, endocrine, and cardiovascular responses during head-out water immersion in legless men. The results of in-situ experiments from ten healthy subjects suggested that our system worked as intended. Ultrastructurally, neoplastic cells characteristically had tubulovesicular system-like structures and variously developed lysosomes in the cytoplasm. Depression, anxiety, and quality of life were assessed by standard questionnaires. In the coin-shaped conization group, 20 of the 25 patients delivered at term.

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If there is a suspicion of occult bone lesion, finely focused, magnified graphics, CT or bone scintigraphy should be used, depending on both the problem faced and availability. To describe the absorption phase a Weibull function and a classical first order input function were compared. Visual judgment of stenosis severity from cine-film or single-photon emission computed tomographic dipyridamole perfusion images was compared to assessment of stenosis severity as measured with digital quantitative coronary angiography. A novel technique to quantify film--tablet interfacial thickness. Significance of Salmonella serovars and the biological properties of the causative agents in the epidemic process in salmonelloses. A comparative analysis with other proteins involved in neurodegenerative disorders reveals that aromatic recognition interfaces might constitute a key structural element to target their aggregation pathways. He noted ptosis in his left eyelid which gradually progressed over a 2 months period to complete ptosis. Patients with LGA have been followed for a median of 17 months (3--44 months), and four failures have occurred. We support our arguments by computer simulations of a coarse-grained model, by scaling arguments and by analyzing states that are created artificially by superimposing the two types of fires. Their structures were elucidated using a combination of multidimensional NMR and MS techniques, and relative stereochemistries were established by NOESY correlations and analysis of coupling constants.

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A nonbonded bivalence approach that dimerizes molecules by intermolecular interactions is proposed for improving affinity, selectivity, and cell permeability. A mitochondrial-like aconitase in the bacterium Bacteroides fragilis: implications for the evolution of the mitochondrial Krebs cycle. The impact of war, famine, and economic decline on marital fertility in Ethiopia. Patellar tilt was restored after 5-mm TT lateralization but not after 10-mm or 15-mm lateralization. The finding that GAL4DB can be cleaved by caspases has important implications for the use of caspases in two-hybrid analysis and in the interpretation of mammalian assays based on GAL4-dependent reporter gene expression. Primary enforcement laws remain a more effective strategy than secondary enforcement laws in getting motor-vehicle occupants to wear their seat belts.

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Celecoxib in arthritis: relative risk management profile and implications for patients. This study sought to determine whether males classified according to sexual behavior and contraceptive use could be distinguished on the basis of religiosity. A fusion protein of interleukin-11 and soluble interleukin-11 receptor acts as a superagonist on cells expressing gp130. In vitro interaction of the antipsychotic agent olanzapine with human cytochromes P450 CYP2C9, CYP2C19, CYP2D6 and CYP3A. Early and prolonged nitroglycerin treatment is indicated in cases of acute MI with mitral incompetence. Both immuno-inactivation and double diffusion analyses demonstrated that the PGK-2 antigen appeared in testes between days 30 and 34 of postnatal development. Clearly, fluoride has raised the threshold of sugar intake at which caries will progress to cavitation, but fluoride has its limits, and caries remains a serious problem for disadvantaged individuals in many industrialized countries and is a rising problem in many developing countries. Surgical anatomy of the scapular spine in the trapezius-osteomuscular flap. Some physics during heating and sintering of powder pressings of hydroxyapatite (HA) under conventional (usual) conditions have been studied. A biphasic suppressive effect of nicotine was observed on lymphocyte proliferative responses to phytohemagglutinin, concanavalin A, and pokeweed mitogen with peaks at 10(-9) and 10(-5) M.

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Patients with CFS had far lower mean scores than the general population control subjects on all eight SF-36 scales. Antibody formation and insulin requirements in diabetic children during treatment with purified commercial pork insulins. Mid-infrared picosecond pump-dump-probe and pump-repump-probe experiments to resolve a ground-state intermediate in cyanobacterial phytochrome Cph1. Pantoprazole is a proton pump inhibitor (PPI) that binds irreversibly and specifically to the proton pump, thereby reducing gastric acid secretion. The blood concentration of lactate, ammonia, noradrenaline, and adrenaline was measured before and after each workload in both groups. These results suggest that cold exposure leads to induce VEGF and bFGF rapidly and transiently in BAT, which in turn stimulate the proliferation of vascular endothelial cells in this tissue. Hysterectomy appears to result in decreased pain with sexual relations.

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Tube-feeding was also more frequent in the treated hypertensive group. We observed tissue- and time-dependent changes in both PLC-beta1a enzyme activity and anti-PLC-beta1a immunoreactivity in each subcellular fraction. The occupational health nurse and the Vietnam veteran: integrating theory and practice. The neoplasm consisted of a non-encapsulated proliferation of irregularly arranged, fusiform cell bundles in fibrous connective tissue. Intensity dependent confidence intervals on microarray measurements of differentially expressed genes: a case study of the effect of MK5, FKRP and TAF4 on the transcriptome. Here we use a mathematical model to predict the impact of a DAA-treatment scale-up on HCV prevalence among PWID and the estimated cost in metropolitan Chicago. A five-step scheme, derived from an eight-step mechanism, is proposed in which the autocatalytic formation of HOCl plays a central role in accounting for this kinetic behavior.

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Oxytocin-neurophysin I mRNA abundance in equine uterine endometrium. The entropy computed using the recent results on condensation of twisted-sector tachyons in this theory is found to be in precise agreement with the Bekenstein-Hawking entropy. Weaker projections were identified in the ventrolateral NTS subnucleus and sparse labeling was seen in the commissural NTS subnucleus. Depletion of Mab21l1 and Mab21l2 messages in mouse embryo arrests axial turning, and impairs notochord and neural tube differentiation. This dysfunction of the dorsal ACC might represent an important ACM pathophysiology. IL-4, TGF-beta 1, and DXS abolished PGE2 production and the expression of COX-2 and cPLA2 but failed to affect the constitutive expression of COX-1 and secreted PLA2. In this review, I will provide a summary of the existing epidemiological and mechanistic evidence on the relationship between systemic metabolism and cancer, flagyl antibiotic 500 mg highlighting debated issues and ongoing investigations. The information drawn from the interviews is then set against a review of the literature on the public interest and government negotiations.

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This is a case report of lichenoid stomatitis associated with lithium carbonate. These results demonstrate a physiological role of cytokines acting through LIFRbeta-containing receptors in the control of VIP expression in sympathetic neurons. We conducted quantitative real-time polymerase chain reaction (PCR) assays of CMV on plasma samples of 1,168 patients in Kuwait who received solid organ transplants from 2012 to 2014 to detect and monitor CMV DNA viral load. EBM must continue to evolve, however, to address a number of issues including scientific underpinnings, moral stance and consequences, and practical matters of dissemination and application. However discontinuation of EFV containing regimens is common in some patients, particularly black patients, due most often to neuropsychiatric side effects. Normal tissue development, homeostasis, senescence, and the sensitivity to radiation injury across the age spectrum. The proliferation changes of transfectants were measured in vitro by proliferation experiment.

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The formation of sex hormones starts from biosynthesis of androstenedione. We administered halothane anesthesia to an 11-year-old child with this syndrome who needed dental treatment. The choice of prior distribution for a covariance cleocin iv dosing matrix in multivariate meta-analysis: a simulation study. Radiopacity of compomers, flowable and conventional resin composites for posterior restorations. Adolescent and young adult heroin and non heroin users: a quantitative and qualitative study of experiences in a therapeutic community.

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PMA treatment or PKC-alpha overexpression also inhibited the tyrosine phosphorylation of IRS-1. The procedure is semi-automatic and offers a number of interactive features. Managing care through managing information: are we headed in the right direction?. Marked bilateral UHN was found in the majority of exposed fetuses, but without evidence of either mechanical obstruction or dysplastic parenchymal lesions. During endochondral bone formation, TUNEL staining was detected in late hypertrophic chondrocytes of the epiphyseal growth plate. Response of vestibular and cerebellar neurons to rotational stimulation. If multiple users live in the same cefpodoxime 200 mg environment, however, data coming from sensors need to be properly tagged: in this paper, a simple technique for such tagging is proposed, which exploits the same wireless transmission used for transmitting data, thus not requiring additional hardware components and avoiding more complex and expensive (radio)localization techniques. Functional analysis of an AMPKalpha1 species carrying a non-phosphorylatable mutation at Ser-173 revealed a critical function of this phosphorylation for efficient release of free fatty acids and glycerol in response to PKA-activating signals.

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Evaluation of unbound serum carbamazepine and carbamazepine-10,11-epoxide concentration prediction methods in polytherapy adult patients with epilepsy. The routes of administration included intravenous, oral, spinal, intramuscular and subcutaneous. C-reactive protein is useful in distinguishing Gram stain-negative bacterial meningitis from viral meningitis in children. We found that the genetic diversity remained similar, while the incidence of N. is rulide penicillin based The aim of this study is to establish tools and standardised quality control procedures for microscopic image analysis systems.

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The above results suggest that CYP1B1 alterations in the coding and UTR are not the primary cause of glaucoma in beagles by possible monogenic association. Our results suggest that the postnatal developmental profile of filamentous actin is affected by visual experience, as a consequence of eye-opening. An innovative approach is proposed for the estimation of hourly average can you treat a yeast infection with flagyl solar radiation on tilted surface. Kirov State Institute for the Advanced Training of Physicians and the organs and institutions of applied public health. Isoniazid-induced convulsions in rats: effects of Ro 15-1788 and beta-CCE.

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Probes of the proteolytic pathway using inhibitors show that the burn-induced stimulation of proteolysis is consistent with the stimulation of lysosomal protease activity. Thirty-four mature human placentae were punctured in situ during cesarean section and fixed immediately. Oral clonidine attenuates the fall in mean arterial pressure due to scalp infiltration with epinephrine-lidocaine solution in patients undergoing craniotomy: a prospective, randomized, double-blind, and placebo controlled trial. It is well known that early decisions are of greatest impact and so, the importance of the initial contacts, communications and consequent decisions are paramount. Median concentrations were 7.05 micrograms.g-1 at 30 min, 7.2 micrograms.g-1 at 60 min., 4 para q sirve flagyl 500 mg .65 micrograms.g-1 at 90 min. The problems arising from certain types of artefact are also discussed. The morphological changes of aortic endothelium were observed under optical microscope and scanning electron microscope (SEM). Present value criterion in mosquito-control decisions was presented with several examples that illustrate its applicability and the modifications it allows. After a 6-month exclusion period, the study used a pre-post design, with baseline and treatment periods defined, respectively, as 5 months before and after receiving sumatriptan therapy.

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To study the incidence of telomerase gene mutations in Chinese patients with acquired bone marrow failure (BMF) and explore its relationship with telomere shortening. Treatment engagement is a well-established performance measure for the treatment of substance use disorders. This paper presents a fast and accurate patient-specific electrocardiogram (ECG) classification and monitoring system. Due to disease progression, a second-line treatment with pemetrexed was started. The effect of size on uptake of orally administered latex microparticles in the small intestine and transport to mesenteric lymph nodes. Outcome measurements included recurrent bleeding, surgery, mortality, blood transfusion, and length of hospital stay.

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Transdisciplinary collaboration is essential in addressing the translation gap between scientific discovery and delivery of evidence-based interventions to prevent and treat diabetes. A set of early-emerging characteristics that may signal risk for later externalizing psychopathology is callous-unemotional (CU) behavior. Although presentation of symptoms does provide some clues about the likelihood of underlying depression, the sensitivity of GP diagnosis remains low and needs to be improved. Abnormal reactivity of an N-heterocyclic carbene (NHC) with a phosphaalkene: a route to a 4-phosphino-substituted NHC. The inducibility of micronuclei by indirect mutagens was particularly interesting. There are many works in mammalian systems detailing the importance of the various domains in EHDs but, to date, the domains of plant EHD2 that are required for its inhibitory activity on endocytosis remained unknown. Affected siblings and probands with premature CHD had higher frequencies of the T allele of the -219G/T promoter polymorphism and the epsilon 4 allele (genotypes epsilon 4/3 or epsilon 4/4) of the apo epsilon 2/epsilon 3/ epsilon 4 polymorphism than those of healthy control subjects. School closure and restraint were able to bring about a delay in the peak of infection.

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