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Menilet (Metronidazole)

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Menilet is an antibiotic and antiprotozoal medication. It is used either alone or with other antibiotics to treat pelvic inflammatory disease, endocarditis, and bacterial vaginosis. It is effective for dracunculiasis, giardiasis, trichomoniasis, and amebiasis.

Other names for this medication:
Anerobia, Arilin, Colpofilin, Diazole, Emedal, Etron, Filmet, Fladystin, Flagolin, Fortagyl, Geloderm, Klont, Menizol, Metazol, Metrajil, Metris, Metrolag, Metrolotion, Metronid, Metronidazol, Metronidazole, Metronour, Metrosa, Metrosil, Metrozol, Metrozole, Metsina, Nidagyl, Orogyl, Otrozol, Rosaced, Rosasol, Rozex, Tismazol, Tolbin, Torgyl, Tricofin, Vagimid, Wingyl, Zyomet

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Also known as: Metronidazole


Menilet (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Menilet is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.


Menilet 250-mg tablets are round, blue, film coated, with SEARLE and 1831 debossed on one side and Menilet and 250 on the other side; bottles of 50, 100, and 2,500. Menilet 500-mg tablets are oblong, blue, film coated, with Menilet debossed on one side and 500 on the other side; bottles of 50, 100, and 500.


Single oral doses of Menilet, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Menilet has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Menilet overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.


Store below 77 degrees F (25 degrees C) and protect from light.

Side effects

The most common side effects associated with Menilet are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Metronidazole is mainly metabolised by hepatic oxidation. Substantial impairment of Metronidazole clearance may occur in the presence of advanced hepatic insufficiency. The risk/benefit ratio of using Metronidazole to treat trichomoniasis in such patients should be carefully considered. Plasma levels of Metronidazole should be closely monitored.

Cases of severe hepatotoxicity/acute hepatic failure, including cases with a fatal outcome with very rapid onset after treatment initiation in patients with Cockayne syndrome have been reported with products containing metronidazole for systemic use. In this population, metronidazole should therefore be used after careful benefit-risk assessment and only if no alternative treatment is available. Liver function tests must be performed just prior to the start of therapy, throughout and after end of treatment until liver function is within normal ranges, or until the baseline values are reached. If the liver function tests become markedly elevated during treatment, the drug should be discontinued.

Patients with Cockayne syndrome should be advised to immediately report any symptoms of potential liver injury to their physician and stop taking metronidazole.

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Persistence of vaccine immunity against hepatitis B virus and response to revaccination in vertically HIV-infected adolescents on HAART. Multilevel growth curve modeling was conducted in 2014 to test hypothesized synergistic effects of the family and neighborhood on trajectories of physical DVV from grade 8 to 12. The 19-methyl and 19-oxo compounds 5 and 7 inactivated aromatase in a time-dependent manner with k(inact) of 0.048 and 0.110 min(-1), respectively, in the presence of NADPH. We found no significant differences in overall distributions between the automated and the manual counts, before as well as after correction. We retrospectively evaluated our experience with complex cystic renal masses on MR imaging, using T1-weighted, T2-weighted, and gadolinium-enhanced images, to determine whether imaging features could permit distinction between benign and malignant lesions. The ratio of leghemoglobin a to leghemoglobin c3 content increases dramatically as very young nodules mature.

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