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Menilet (Metronidazole)
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Menilet

Menilet is an antibiotic and antiprotozoal medication. It is used either alone or with other antibiotics to treat pelvic inflammatory disease, endocarditis, and bacterial vaginosis. It is effective for dracunculiasis, giardiasis, trichomoniasis, and amebiasis.

Other names for this medication:
Anerobia, Arilin, Colpofilin, Diazole, Emedal, Etron, Filmet, Fladystin, Flagolin, Fortagyl, Geloderm, Klont, Menizol, Metazol, Metrajil, Metris, Metrolag, Metrolotion, Metronid, Metronidazol, Metronidazole, Metronour, Metrosa, Metrosil, Metrozol, Metrozole, Metsina, Nidagyl, Orogyl, Otrozol, Rosaced, Rosasol, Rozex, Tismazol, Tolbin, Torgyl, Tricofin, Vagimid, Wingyl, Zyomet

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Also known as: Metronidazole

Description

Menilet (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Menilet is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.

Dosage

Menilet 250-mg tablets are round, blue, film coated, with SEARLE and 1831 debossed on one side and Menilet and 250 on the other side; bottles of 50, 100, and 2,500. Menilet 500-mg tablets are oblong, blue, film coated, with Menilet debossed on one side and 500 on the other side; bottles of 50, 100, and 500.

Overdose

Single oral doses of Menilet, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Menilet has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Menilet overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.

Storage

Store below 77 degrees F (25 degrees C) and protect from light.

Side effects

The most common side effects associated with Menilet are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Metronidazole is mainly metabolised by hepatic oxidation. Substantial impairment of Metronidazole clearance may occur in the presence of advanced hepatic insufficiency. The risk/benefit ratio of using Metronidazole to treat trichomoniasis in such patients should be carefully considered. Plasma levels of Metronidazole should be closely monitored.

Cases of severe hepatotoxicity/acute hepatic failure, including cases with a fatal outcome with very rapid onset after treatment initiation in patients with Cockayne syndrome have been reported with products containing metronidazole for systemic use. In this population, metronidazole should therefore be used after careful benefit-risk assessment and only if no alternative treatment is available. Liver function tests must be performed just prior to the start of therapy, throughout and after end of treatment until liver function is within normal ranges, or until the baseline values are reached. If the liver function tests become markedly elevated during treatment, the drug should be discontinued.

Patients with Cockayne syndrome should be advised to immediately report any symptoms of potential liver injury to their physician and stop taking metronidazole.

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We present a detailed study of the extrusion of an imperfect palindrome, derived from the terminal regions of vaccinia virus DNA and contained in a superhelical plasmid, into a cruciform containing bulged bases. A Modeling and Simulation Framework for Adverse Events in Erlotinib-Treated Non-Small-Cell Lung Cancer Patients. Few studies have been conducted comparing the FMR1 mutation in multiple tissues of individuals affected with fragile X syndrome. The present meta-analysis did not find an increased rate of anesthetic or surgical complications in infant implantees, although long-term follow-up and large numbers are lacking. The GFP is a useful marker in environmental microorganisms, allowing new research that will increase our understanding of microorganisms in the environment. The National Institute for Health and Care Excellence has produced a new guideline looking at improving the health and wellbeing of employees, with a particular focus on organisational culture and context, and the role of line managers. Such mutations have been mapped and used to create new alphavirus vectors for noncytopathic gene expression in mammalian cells.

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