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Medamet (Metronidazole)
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Medamet

Medamet is used to treat bacterial infections in different areas of the body. The extended-release tablets are used to treat women with vaginal infections (bacterial vaginosis).

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Anerobia, Clont, Dirozyl, Elyzol, Etronil, Flagemed, Florazole, Ginkan, Imizine, Lindoplus, Metazole, Metrajil, Metrobac, Metrocreme, Metrodal, Metrogyl, Metrolyl, Metrosa, Metsina, Nidazyl, Padet, Promuba, Repligen, Rozagel, Suanatem, Taremis, Tricodazol, Trikozol, Vertisal

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Also known as: Metronidazole

Description

Medamet (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Medamet is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.

Dosage

In the Female. One-day treatment – two grams of Medamet, given either as a single dose or in two divided doses of one gram each, given in the same day. Seven-day course of treatment – 250 mg three times daily for seven consecutive days. There is some indication from controlled comparative studies that cure rates as determined by vaginal smears and signs and symptoms, may be higher after a seven-day course of treatment than after a one-day treatment regimen.

The dosage regimen should be individualized. Single-dose treatment can assure compliance, especially if administered under supervision, in those patients who cannot be relied on to continue the seven-day regimen. A seven-day course of treatment may minimize reinfection by protecting the patient long enough for the sexual contacts to obtain appropriate treatment. Further, some patients may tolerate one treatment regimen better than the other.

Pregnant patients should not be treated during the first trimester In pregnant patients for whom alternative treatment has been inadequate, the one-day course of therapy should not be used, as it results in higher serum levels which can reach the fetal circulation.

When repeat courses of the drug are required, it is recommended that an interval of four to six weeks elapse between courses and that the presence of the trichomonad be reconfirmed by appropriate laboratory measures. Total and differential leukocyte counts should be made before and after re-treatment.

Overdose

Single oral doses of Medamet, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Medamet has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Medamet overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.

Storage

Store at room temperature below 25 degrees C (77 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Medamet are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

To reduce the development of drug-resistant bac- teria and maintain the effectiveness of Medamet and other antibacterial drugs, Medamet should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

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We sought to ascertain the effect of switching from an open infusion system to a closed system on rates and sequelae of central venous catheter (CVC)-associated bloodstream infection in the intensive care department (ICU) of 2 hospitals in Argentina. Because the evolutionary process goes along the time course, it can be described by differential equation. To evaluate the ability of an artificial neural network (ANN) to identify brain structures. These results may facilitate understanding the microbial succession during APMs manufacture. For this reason, numerical techniques, such as finite element method, are often used for solving the forward problem in 3D rather than analytical solutions which can only model simple geometrical shapes. Prostaglandin F2alpha (PGF2alpha) was used intramuscularly in two preliminary trials to determine its effect in cycling buffalo cows. Methylene blue and fatal encephalopathy from ackee fruit poisoning. In a 37 year old male patient a solitary hemangioblastoma of the cauda equina was demonstrated by myelography and totally removed by laminectomy. Heparin coating of the extracorporeal circuit reduces the inflammatory response during cardiopulmonary bypass. Experience at the National Institute of Cancerology in Mexico City.

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Sleep apnea and milder forms of sleep-disordered breathing (SDB) have been associated with overt clinical cardiovascular disease, but it is unknown whether SDB is associated with arterial microvascular pathology. They neither bound to mouse IgG-Sepharose nor inhibited rosette formation of PBL with Eo sensitized with rabbit IgG antibodies. The orbitozygomatic infratemporal fossa approach: a quantitative anatomical study. Characterisation of steady-state and transient responses of transcutaneous pO2 and pCO2 by mass spectrometry. Cytokine production in response to neoglycoconjugates containing enzymatically synthesized glycans also was measured. Hypothalamic 5 alpha-reductase and 3 alpha-oxidoreductase activity in the male rat. The 14C-clearance curves were nonlinear, consisting of an initial rapid phase followed by a slow phase of clearance. Influence of whole-body gamma irradiation upon arachidonic acid metabolism in rat platelets.

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A very significant correlation between the hydrogen peroxide apoplastic level and the growth rate as well as between the ascorbate/hydrogen peroxide molar ratio and the growth rate of hypocotyls have been found suggesting that the redox state is the main factor controlling the cell wall stiffening mechanism and thus growth in pine hypocotyls. The novel protein kinase C (PKC) isoform, PKC theta, is selectively expressed in T lymphocytes and is a sine qua non for T cell antigen receptor (TCR)-triggered activation of mature T cells. Dispersing the 15 mg lansoprazole orally disintegrating tablet in water and administering the dose orally via syringe is bioequivalent to the 15 mg intact lansoprazole orally disintegrating tablet with respect to lansoprazole area under the plasma concentration and C(max). Cardiac troponin T exon 13 lysine deletions can cause FDC of varying severity and are an important but uncommon cause of FDC. These findings suggested that intradental ischemia due to cadmium toxicity may have contributed to the development of the pulpal necrosis.

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Of the 101 workers, 82 who had spirometry performed with each spirometer had at least two acceptable curves, and 51 workers tested with each spirometer had curves that met all American Thoracic Society (ATS) criteria for spirometry. After 12 hours, mucin dots appeared in clumps of epithelial cells and gradually became larger, and the epithelial cell clumps were transformed into multicellular cysts after 1 to 2 days. REZ-1 cochlear implant electrode array was implanted in 22 human temporal bone specimens. Endoscopic biliary stenting for the palliation of pancreatic cancer: results, survival predictive factors, and comparison of 10-French with 11.5-French gauge stents. However, the efficiency of full-length TCR (flTCR)-transduced T cells could be limited by factors such as incorrect pairing between exogenous and endogenous TCR chains and downregulation of the CD3 complex. In addition, overexpression of Ikaros-1 in primary striatal cultures increases the number of calbindin- and ENK-positive neurons. Epigenetics: a molecular link between environmental factors and type 2 diabetes. Integrated proteomic analysis of cancer mouse models and human cancer cell populations provides an effective approach to identify potential circulating protein biomarkers.

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Virus proteins are produced by proteolytic cleavage by cellular and virus encoded proteinases. Importation of the brown dog or kennel tick (Rhipicephalus sanguineus) into the UK. Four combinations of MR images were reviewed by two neuroradiologists: T1-weighted and dual T2-weighted fast spin-echo images, T1- and T2-weighted fat-suppressed fast spin-echo images, T1-weighted and contrast-enhanced T1-weighted fat-suppressed spin-echo images, and unenhanced and contrast-enhanced 3D time-of-flight MR angiograms. Comparative NMR studies of diffusional water permeability of red blood cells from different species: XVI Dingo (Canis familiaris dingo) and dog (Canis familiaris). Calculating mixed venous saturation during veno-venous extracorporeal membrane oxygenation. Receptors were quantitated by using CR1-specific monoclonal antibody by radioimmunoassay or flow cytometry and by rosette analysis with the use of C3b-coated bovine erythrocytes. Moreover, altered MT1-MMP proteolytic turnover and differential regulation of TIMP expression in AAAs suggest that tight regulatory mechanisms are involved in the molecular regulation of MMP activation processes in the pathogenesis of AAAs. In renal allograft recipients, ultrasound resistance indices (RI) have been discussed as predictors of transplant survival. A comparison of Lmb with other metal transporters revealed an interesting feature of the dimerization of molecules in the crystallographic asymmetric unit in all zinc-binding transporters.

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Thus, when examining victims of such traumas, the possibility that a foreign object might have penetrated the body should be kept in mind. The 24-hour sampling period was repeated twice for each teacher. A simple, inexpensive procedure is described for rapidly screening small samples of honey for sulfathiazole (ST), a drug formerly used but not approved in the United States for the prophylactic treatment of American foulbrood disease of bees. Taken together, these results suggest that neomycin is an attractive candidate for the development of novel antimigratory molecules useful for the treatment of gliomas. Mental retardation in a boy with an interstitial deletion at Xp22.3 involving STS, KAL1, and OA1: implication for the MRX locus. Multilevel logistic regression models were fitted to examine associations between state Medicaid dental-procedure reimbursement and receipt of preventive dental care. To compare patient reports of present and worst cancer-related pain intensity to the recalled intensity of several commonly experienced types of pain. The stoichiometry of electron and nitrate consumption and nitrite accumulation were consistent with the electrode serving as the sole electron donor for nitrate reduction. We report a case of basaloid squamous cell carcinoma for its relative rarity, which was diagnosed in a 52 year old woman, with a brief review of literature.

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One patient underwent arytenoidectomy and one patient has a tracheostomy. This is the first description of a phenazine hydroxylation gene in Streptomyces, and the results of this study lay the foundation for further investigation of phenazine metabolite biosynthesis in Streptomyces. Doppler echocardiography showed severe mitral regurgitation due to prolapse of posterior mitral leaflet. Southeast Asia and East Asia are regarded as highly endemic regions for hepatitis B virus (HBV) and include many popular destinations for Australian travellers. Finally, a 70-kDa activity was immunoprecipitated from RNA-protein complexes formed in vitro between cytoplasmic proteins of human lymphocytes and AU-rich RNA.

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Pustulosis palmaris et plantaris associated with peripheral neuropathy. When making such a decision, patients can use female plastic surgeons as a resource for information, thus helping them to make an informed decision. Few infant animal models have been used to study infantile short bowel syndrome (SBS). and Neidium ampliatum decreased in assemblages from the polluted streams that were transferred to the reference stream. CAA may be one of the most common causes of bicytopenia or pancytopenia during pregnancy, MDS may be the second. Oropharyngeal colonization by Gram-negative bacteria in elderly hospitalized patients: incidence and risk factors. Total glycoprotein synthesis was inhibited at all times by omeprazole, but only after the cessation of dosing with famotidine. measurements, were explained by assuming the formation of species of the type MH2PNS ed M2H2PNS, where M indicates a cation. Materno-fetal blood group incompatibility in chimpanzee is described as a contributing factor in the death of an infant. In their very first years of adoption, HT crops often led to some decrease in herbicide use.

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3alpha/beta,20beta-hydroxysteroid dehydrogenase (porcine testicular carbonyl reductase) also has a cysteine residue that is involved in binding of cofactor NADPH. Myenteric neuronal antibodies in scleroderma: passive transfer evokes alterations in intestinal myoelectric activity in a rat model. These data do not support a role for ANP in the regulation of prostaglandins and renin release by rat glomeruli. At any time, when we flagyl 500 mg increased the dose, we saw an increment of the height afterwards. The bump position improves the likelihood of successful central venous catheter placement. Married patients had significantly longer median survival than those who were divorced, single, separated or widowed. The anti-basement membrane zone antibodies in serum samples from normal elderly subjects were compared with those in serum samples from normal young subjects. Our data suggest that the risk of developing UVR-induced CM in a skin type is correlated with the level of cutaneous pigmentation and its ethnic background. In view of the well recognized need of reject water treatment in MWWTP (municipal wastewater treatment plant), this paper outlines two strategies for P removal from reject water using alum sludge, which is produced as by-product in drinking water treatment plant when aluminium sulphate is used for flocculating raw waters.

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Critically ill patients may benefit from strict glucose control. The composition of acyl chains and their positions in the triacylglycerols of the oil extracted from seeds of Moringa oleifera were studied by (13)C NMR spectroscopy. Mechanism of Binding to Ebola Virus Glycoprotein by the ZMapp, ZMAb, and MB-003 Cocktail Antibodies. Patients with nonischemic dilated cardiomyopathy are at substantial risk for sudden death from cardiac causes. Parity-adjusted prevalences were obtained by applying correction factors to the observed prevalences in parous and nulliparous ANC attenders. Fluorescence resonance energy transfer (FRET) between the QDs (donors) and the fluorescent dye molecules (acceptors) was used to obtain information on the conformational dynamics of the immobilized polymers.

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