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Medamet (Metronidazole)

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Medamet is used to treat bacterial infections in different areas of the body. The extended-release tablets are used to treat women with vaginal infections (bacterial vaginosis).

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Also known as: Metronidazole


Medamet (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Medamet is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.


In the Female. One-day treatment – two grams of Medamet, given either as a single dose or in two divided doses of one gram each, given in the same day. Seven-day course of treatment – 250 mg three times daily for seven consecutive days. There is some indication from controlled comparative studies that cure rates as determined by vaginal smears and signs and symptoms, may be higher after a seven-day course of treatment than after a one-day treatment regimen.

The dosage regimen should be individualized. Single-dose treatment can assure compliance, especially if administered under supervision, in those patients who cannot be relied on to continue the seven-day regimen. A seven-day course of treatment may minimize reinfection by protecting the patient long enough for the sexual contacts to obtain appropriate treatment. Further, some patients may tolerate one treatment regimen better than the other.

Pregnant patients should not be treated during the first trimester In pregnant patients for whom alternative treatment has been inadequate, the one-day course of therapy should not be used, as it results in higher serum levels which can reach the fetal circulation.

When repeat courses of the drug are required, it is recommended that an interval of four to six weeks elapse between courses and that the presence of the trichomonad be reconfirmed by appropriate laboratory measures. Total and differential leukocyte counts should be made before and after re-treatment.


Single oral doses of Medamet, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Medamet has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Medamet overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.


Store at room temperature below 25 degrees C (77 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Medamet are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


To reduce the development of drug-resistant bac- teria and maintain the effectiveness of Medamet and other antibacterial drugs, Medamet should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

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We sought to ascertain the effect of switching from an open infusion system to a closed system on rates and sequelae of central venous catheter (CVC)-associated bloodstream infection in the intensive care department (ICU) of 2 hospitals in Argentina. Because the evolutionary process goes along the time course, it can be described by differential equation. To evaluate the ability of an artificial neural network (ANN) to identify brain structures. These results may facilitate understanding the microbial succession during APMs manufacture. For this reason, numerical techniques, such as finite element method, are often used for solving the forward problem in 3D rather than analytical solutions which can only model simple geometrical shapes. Prostaglandin F2alpha (PGF2alpha) was used intramuscularly in two preliminary trials to determine its effect in cycling buffalo cows. Methylene blue and fatal encephalopathy from ackee fruit poisoning. In a 37 year old male patient a solitary hemangioblastoma of the cauda equina was demonstrated by myelography and totally removed by laminectomy. Heparin coating of the extracorporeal circuit reduces the inflammatory response during cardiopulmonary bypass. Experience at the National Institute of Cancerology in Mexico City.

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Sleep apnea and milder forms of sleep-disordered breathing (SDB) have been associated with overt clinical cardiovascular disease, but it is unknown whether SDB is associated with arterial microvascular pathology. They neither bound to mouse IgG-Sepharose nor inhibited rosette formation of PBL with Eo sensitized with rabbit IgG antibodies. The orbitozygomatic infratemporal fossa approach: a quantitative anatomical study. Characterisation of steady-state and transient responses of transcutaneous pO2 and pCO2 by mass spectrometry. Cytokine production in response to neoglycoconjugates containing enzymatically synthesized glycans also was measured. Hypothalamic 5 alpha-reductase and 3 alpha-oxidoreductase activity in the male rat. The 14C-clearance curves were nonlinear, consisting of an initial rapid phase followed by a slow phase of clearance. Influence of whole-body gamma irradiation upon arachidonic acid metabolism in rat platelets.

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A very significant correlation between the hydrogen peroxide apoplastic level and the growth rate as well as between the ascorbate/hydrogen peroxide molar ratio and the growth rate of hypocotyls have been found suggesting that the redox state is the main factor controlling the cell wall stiffening mechanism and thus growth in pine hypocotyls. The novel protein kinase C (PKC) isoform, PKC theta, is selectively expressed in T lymphocytes and is a sine qua non for T cell antigen receptor (TCR)-triggered activation of mature T cells. Dispersing the 15 mg lansoprazole orally disintegrating tablet in water and administering the dose orally via syringe is bioequivalent to the 15 mg intact lansoprazole orally disintegrating tablet with respect to lansoprazole area under the plasma concentration and C(max). Cardiac troponin T exon 13 lysine deletions can cause FDC of varying severity and are an important but uncommon cause of FDC. These findings suggested that intradental ischemia due to cadmium toxicity may have contributed to the development of the pulpal necrosis.

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