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Gynotran (Metronidazole)
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Gynotran

Gynotran is a medicine used to treat different types of bacterial and parasitic infections, including those that affect the skin, vagina, blood, heart, bone, stomach, liver, joints, nervous system, respiratory tract, and other areas of the body.

Other names for this medication:
Acuzole, Aldezole, Amevan, Amrizole, Birodogyl, Colpofilin, Dequazol, Flagenase, Flagicure, Flagolin, Flazole, Geloderm, Ginkan, Gnostol, Gynoplix, Kilpro, Mebadiol, Medazol, Menilet, Metrajil, Metrazol, Metrobac, Metrogyl, Metrol, Metrolag, Metrolyl, Metronidazole, Metronide, Metropast, Metrosa, Metrosept, Metrozine, Metrozol, Metrozole, Nidazol, Novazole, Rhodogil, Rosasol, Rosiced, Rozamet, Rozex, Tolbin, Torgyl, Trichopol, Triconex, Wingyl, Zyomet

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Suprax, Flagyl, Chloromycetin, Avelox, Noroxin, Ceftin

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Also known as: Metronidazole

Description

Gynotran (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Gynotran is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.

Dosage

The usual adult oral dosage is 7.5 mg/kg every six hours (approx. 500 mg for a 70-kg adult). A maximum of 4 g should not be exceeded during a 24-hour period.

The usual duration of therapy is 7 to 10 days; however, infections of the bone and joint, lower respiratory tract, and endocardium may require longer treatment.

Patients with severe hepatic disease metabolize metronidazole slowly, with resultant accumulation.

Overdose

Single oral doses of Gynotran, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Gynotran has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Gynotran overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.

Storage

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

Side effects

The most common side effects associated with Gynotran are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Psychotic Reaction with Disulfiram. Use of oral metronidazole is associated with psychotic reactions in alcoholic patients who were using disulfiram concurrently. Do not administer metronidazole to patients who have taken disulfiram within the last two weeks.

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