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Grinazole (Metronidazole)
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Grinazole

Flagyl is an oral antiprotozoal and antibacterial. It is thought to work by entering the bacterial cell, acting on some components of the cell, and destroying the bacteria. Treating certain infections caused by bacteria or amoebas. It may also be used for other conditions as determined by your doctor.

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Also known as: Metronidazole

Description

Grinazole (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Grinazole is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.

Dosage

Grinazole 250-mg tablets are round, blue, film coated, with SEARLE and 1831 debossed on one side and Grinazole and 250 on the other side; bottles of 50, 100, and 2,500. Grinazole 500-mg tablets are oblong, blue, film coated, with Grinazole debossed on one side and 500 on the other side; bottles of 50, 100, and 500.

Overdose

Single oral doses of Grinazole, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Grinazole has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Grinazole overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.

Storage

Store Grinazole at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Grinazole out of the reach of children and away from pets.

Side effects

The most common side effects associated with Grinazole are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Hypersensitivity. Grinazole Tablets is contraindicated in patients with a prior history of hypersensitivity to metronidazole or other nitroimidazole derivatives. In patients with trichomoniasis, Grinazole Tablets is contraindicated during the first trimester of pregnancy.

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