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Geromycin (Clarithromycin)
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Geromycin

Geromycin is used to treat bacterial infections in many different parts of the body. It is also used in combination with other medicines to treat duodenal ulcers caused by H. pylori. This medicine is also used to prevent and treat Mycobacterium avium complex (MAC) infection.

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Also known as: Clarithromycin

Description

Geromycin is used to treat many different types of bacterial infections affecting the skin and respiratory system. Geromycin is also used together with other medicines to treat stomach ulcers caused by Helicobacter pylori. Geromycin fights bacteria in the body. Geromycin is also known as Clarithromycin, Maclar, Klaricid, Klacid, Clarimac, Claribid.

Dosage

The recommended daily dosage is 15 mg/kg/day divided every 12 hours for 10 days (up to the adult dose). Refer to dosage regimens for mycobacterial infections in pediatric patients for additional dosage information.

For the treatment of disseminated infection due to Mycobacterium avium complex (MAC), Geromycin Filmtab and Geromycin Granules are recommended as the primary agents. Geromycin Filmtab and Geromycin Granules should be used in combination with other antimycobacterial drugs (e.g. ethambutol) that have shown in vitro activity against MAC or clinical benefit in MAC treatment.

For treatment and prophylaxis of mycobacterial infections in adults, the recommended dose of Geromycin is 500 mg every 12 hours.

For treatment and prophylaxis of mycobacterial infections in pediatric patients, the recommended dose is 7.5 mg/kg every 12 hours up to 500 mg every 12 hours.

Geromycin therapy should continue if clinical response is observed. Geromycin can be discontinued when the patient is considered at low risk of disseminated infection.

Overdose

If you overdose Geromycin and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Geromycin overdosage: nausea, vomiting, diarrhea, abdominal discomfort.

Storage

Store Geromycin XL Filmtab at 20 to 25 degrees C (68 to 77 degrees F). Excursions permitted to 15 to 30 degrees C (59 to 86 degrees F).

Side effects

The most common side effects associated with Geromycin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Concomitant cisapride, pimozide, ergots, HMG-CoA reductase inhibitors extensively metabolized by CYP3A4 (lovastatin or simvastatin). History of QT prolongation or ventricular cardiac arrhythmia (including torsades de pointes). Concomitant colchicine (in renal or hepatic impairment). Cholestatic jaundice/hepatic dysfunction with prior clarithromycin use.

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Hepatocytes in culture for 10 days or less exhibited large lamellar arrays of rough endoplasmic reticulum, well developed Golgi complexes, and structures resembling bile canaliculi, which possess tight junctions and desmosomes separating them from the intercellular space. The duration of ethanol-induced narcosis was significantly shorter and blood ethanol concentration at the moment of righting reflex recovery was higher in pyrithiamin-treated rats than in controls. There have been recent reports in the literature that the social environment is associated with disease and mortality risks, independent of individual risk factors. Tc-99m-labeled red blood cell scan showing gastrointestinal bleeding point, and also showing an incidental hepatic hemangioma. Exosome-mediated splicing may regulate alternative splicing of NCU05290, NCU07421 and the circadian clock gene frequency (frq). Thus, the Therapore System was found to have negligible perturbations of the interacting biological systems evaluated even with the highly sensitive RIA procedures employed.

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