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Florazole (Metronidazole)
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Florazole

Florazole eliminates bacteria and other microorganisms that cause infections of the reproductive system, gastrointestinal tract, skin, vagina, and other areas of the body. Antibiotics will not work for colds, flu, or other viral infections. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Other names for this medication:
Acuzole, Aldezol, Aldezole, Aminidazole, Amodis, Anaeromet, Anegyn, Arilin, Avidal, Bemetrazole, Biatron, Clont, Corsagyl, Dazotron, Dequazol, Flagemed, Flagolin, Flegyl, Fortagyl, Ginkan, Gynotran, Klion, Metrajil, Metrocev, Metronour, Metrozol, Minegyl, Nalox, Nidagyl, Nidazyl, Onida, Pharmaflex, Promuba, Rhodogil, Rosalox, Rosasol, Rupezol, Suanatem, Trichazole, Trichex, Trichodazol, Tricofin, Tricozyl, Trikozol, Unigyl, Vandazole, Varizil, Zidoval

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Also known as: Metronidazole

Description

Florazole (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Florazole is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.

Dosage

Florazole 250-mg tablets are round, blue, film coated, with SEARLE and 1831 debossed on one side and Florazole and 250 on the other side; bottles of 50, 100, and 2,500. Florazole 500-mg tablets are oblong, blue, film coated, with Florazole debossed on one side and 500 on the other side; bottles of 50, 100, and 500.

Overdose

Single oral doses of Florazole, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Florazole has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Florazole overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.

Storage

Store Florazole at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Florazole out of the reach of children and away from pets.

Side effects

The most common side effects associated with Florazole are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Psychotic Reaction with Disulfiram. Use of oral metronidazole is associated with psychotic reactions in alcoholic patients who were using disulfiram concurrently. Do not administer metronidazole to patients who have taken disulfiram within the last two weeks.

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A consecutive series of 29 patients with angiographically confirmed CV received intra-arterial CDH (IAC) therapy. At gestation day 11 the number of embryos with an open cranial neural tube had increased with the dose. The C1 gene of tomato yellow leaf curl geminivirus (TYLCV) encodes a multifunctional protein (Rep) involved in replication. An examination of 1009 backcross animals produced from H-2b/H-2t1 heterozygotes resulted in the detection of four cases of intra-H-2 recombination. In this article, we develop 3 empirical Bayes methods for gene ranking on the basis of differential expression, using hierarchical mixture models.

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