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Erythrocin (Erythromycin)

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Erythrocin is used to prevent and treat infections in many different parts of the body, including respiratory tract infections, skin infections, diphtheria, intestinal amebiasis, acute pelvic inflammatory disease, Legionnaire's disease, pertussis, and syphilis.

Other names for this medication:
Cynopryl, Eltocin, Erypal, Erythrocin, Erythrokem, Erythromycin, Estocin, Pediazole

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Also known as: Erythromycin


Erythrocin is a prescription medication used to treat infections caused by bacteria. Erythrocin belongs to a group of drugs called macrolide antibiotics. These work by killing or stopping the growth of the bacteria that cause infections. This medication comes in capsule, tablet, long-acting capsule, long-acting tablet, chewable tablet, suspension, and pediatric drop forms for oral use. It is usually taken 3 to 4 times daily.

This medication also comes in topical solution and gel forms and as an ophthalmic ointment. Do not chew, divide, or break the long-acting capsules and tablets. Swallow these whole and take with a full glass of water. This medication is also available in an injectable form to be given directly into a vein (IV) by a healthcare professional. Common side effects of Erythrocin include stomach upset, diarrhea, vomiting, stomach cramps, mild skin rash, and stomach pain. Ophthalmic Erythrocin can also cause blurred vision. Do not drive or operate heavy machinery until you know how Erythrocin affects you.


Generic Erythrocin can be taken in form of tablets (250 mg, 500 mg), extended-release tablets, capsules and extended-release capsules. You should take it by mouth. It is better to take Generic Erythrocin on empty stomach (but if you experience upset stomach take Erythrocin food or milk). Take it 1-2 hours before or 2 hours after your meal. Do not crush, chew, or break the tablet. Swallow it whole with water. Do not stop taking Generic Erythrocin suddenly.


In case of overdosage, Erythrocin should be discontinued. Overdosage should be handled with the prompt elimination of unabsorbed drug and all other appropriate measures should be instituted.

Erythrocin is not removed by peritoneal dialysis or hemodialysis.


Store according to directions on package. Do not freeze. Check the expiration date of your prescription and discard any unused portion after that date or after your doctor tells you to stop taking it.

Side effects

The most common side effects associated with Erythrocin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Prescribing Erythrocin Tablets in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.

Since Erythrocin is principally excreted by the liver, caution should be exercised when Erythrocin is administered to patients with impaired hepatic function.

Exacerbation of symptoms of myasthenia gravis and new onset of symptoms of myasthenic syndrome has been reported in patients receiving Erythrocin therapy.

There have been reports of infantile hypertrophic pyloric stenosis (IHPS) occurring in infants following Erythrocin therapy. In one cohort of 157 newborns who were given Erythrocin for pertussis prophylaxis, seven neonates (5%) developed symptoms of non-bilious vomiting or irritability with feeding and were subsequently diagnosed as having IHPS requiring surgical pyloromyotomy. A possible dose-response effect was described with an absolute risk of IHPS of 5.1% for infants who took Erythrocin for 8 to 14 days and 10% for infants who took Erythrocin for 15 to 21 days.5 Since Erythrocin may be used in the treatment of conditions in infants which are associated with significant mortality or morbidity (such as pertussis or neonatal Chlamydia trachomatis infections), the benefit of Erythrocin therapy needs to be weighed against the potential risk of developing IHPS. Parents should be informed to contact their physician if vomiting or irritability with feeding occurs.

Prolonged or repeated use of Erythrocin may result in an overgrowth of nonsusceptible bacteria or fungi. If superinfection occurs, Erythrocin should be discontinued and appropriate therapy instituted.

When indicated, incision and drainage or other surgical procedures should be performed in conjunction with antibiotic therapy.

Observational studies in humans have reported cardiovascular malformations after exposure to drug products containing Erythrocin during early pregnancy.

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