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Dynoxytet (Oxytetracycline)
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Dynoxytet

Dynoxytet is used for treating infections caused by certain bacteria. Dynoxytet is a tetracycline antibiotic. It works by slowing the growth of sensitive bacteria by interfering with the production of proteins needed by the bacteria to grow. Slowing the bacteria's growth allows the body's defense mechanisms to destroy them.

Other names for this medication:
Betacycline, Cotet, Dynoxytet, Ecomycin, Geomicina, Innolyre, Oxyteracin, Oxytetracycline, Tetracin

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Also known as: Oxytetracycline

Description

Dynoxytet is primarily bacteriostatic and is thought to exert its antimicrobial effect by the inhibition of protein synthesis. Dynoxytet is active against a wide range of gram-negative and gram-positive organisms.

The drugs in the Dynoxytet class have closely similar antimicrobial spectra, and cross resistance among them is common. Microorganisms may be considered susceptible if the M.I.C. (minimum inhibitory concentration) is not more than 4.0 mcg/ml and intermediate if the M.I.C. is 4.0 to 12.5 mcg/ml.

Susceptibility plate testing: A Dynoxytet disc may be used to determine microbial susceptibility to drugs in the Dynoxytet class. If the Kirby-Bauer method of disc susceptibility testing is used, a 30 mcg Dynoxytet disc should give a zone of at least 19 mm when tested against a Dynoxytet-susceptible bacterial strain.

Dynoxytets are readily absorbed and are bound to plasma proteins in varying degree. They are concentrated by the liver in the bile, and excreted in the urine and feces at high concentrations and in a biologically active form.

Dosage

Take Dynoxytet by mouth with a full glass of water on an empty stomach at least 1 hour before or 2 hours after eating. Do not lie down for 30 minutes after taking Dynoxytet. Avoid taking milk, dairy products, calcium-enriched juices before and after consuming the drug. It is better to take Dynoxytet every day at the same time. Dynoxytet treats different types of bacterial infections and can be used both by adults and by children. Thus, each age has different instructions. For children above 8 years of age: the usual daily dose is 25–50 mg per kg of body weight divided into 4 equal doses. For Adults: the usual daily dose is 1–2 g divided in 4 equal doses, depending on the severity of the infection. For treatment of brucellosis, 500 mg oxytetracycline four times daily for 3 weeks should be accompanied by streptomycin, 1 gram intramuscularly twice daily the first week, and once daily the second week. For treatment of uncomplicated gonorrhea, when penicillin is contraindicated, tetracycline may be used for the treatment of both males and females in the following divided dosage schedule: 1.5 grams initially followed by 0.5 gram q.i.d. for a total of 9.0 grams. For treatment of syphilis, a total of 30–40 grams in equally divided doses over a period of 10–15 days should be given. Do not stop taking Dynoxytet suddenly. Therapy should be continued for at least 24–48 hours after symptoms and fever have subsided.

Overdose

If an overdose occurs and you are not feeling well, you should seek emergency medical attention or contact your healthcare provider immediately. Symptoms of Dynoxytet overdose: retching, diarrhoea, nausea.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Dynoxytet are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

This drug is contraindicated in persons who have shown hypersensitivity to any of the tetracyclines.

As with other antibiotic preparations, use of this drug may result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs, the antibiotic should be discontinued and appropriate therapy instituted.

In venereal diseases when coexistent syphilis is suspected, a dark field examination should be done before treatment is started and the blood serology repeated monthly for at least 4 months.

Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.

In long term therapy, periodic laboratory evaluation of organ systems, including hematopoietic, renal and hepatic studies should be performed.

All infections due to Group A beta-hemolytic streptococci should be treated for at least 10 days.

Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline in conjunction with penicillin.

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