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Disithrom (Azithromycin)
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Disithrom

Disithrom is an antibiotic. It's widely used to treat chest infections such as pneumonia, infections of the nose and throat such as sinus infection (sinusitis), skin infections, Lyme disease, and some sexually transmitted infections.

Other names for this medication:
Azadose, Azalid, Azatril, Azibiot, Azicin, Azicu, Azimac, Azimakrol, Azinix, Azirox, Azithrex, Azithrox, Azitrocin, Azitromicina, Azomax, Azycyna, Bactexina, Bactrazol, Clearsing, Ericiclina, Fabramicina, Faxin, Goxil, Ilozin, Macromax, Macrozit, Maczith, Magnabiotic, Medimacrol, Neofarmiz, Novatrex, Novozithron, Opeazitro, Ordipha, Orobiotic, Ricilina, Sumamed, Unizitro, Vinzam, Zedd, Zetamax, Zifin, Zirocin, Zistic, Zithrin, Zitrex, Zitrocin, Zitrofar, Zitroken, Zomax

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Omnicef, Chloromycetin, Zithromax, Floxin, Ceftin, Flagyl, Avelox, Ilosone, Cefixime, Cipro

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Also known as: Azithromycin

Description

Disithrom (Disithrom tablets and Disithrom for oral suspension) contain the active ingredient azithromycin, a macrolide antibacterial drug, for oral administration. Disithrom has the chemical name (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl) oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one. Disithrom is derived from erythromycin; however, it differs chemically from erythromycin in that a methyl-substituted nitrogen atom is incorporated into the lactone ring. Its molecular formula is C38H72N2O12, and its molecular weight is 749.00.

Disithrom, as the dihydrate, is a white crystalline powder with a molecular formula of C38H72N2O12∙2H2O and a molecular weight of 785.0.

Disithrom is supplied as tablets containing azithromycin dihydrate equivalent to either 250 mg or 500 mg azithromycin and the following inactive ingredients: dibasic calcium phosphate anhydrous, pregelatinized starch, sodium croscarmellose, magnesium stearate, sodium lauryl sulfate, hypromellose, lactose, titanium dioxide, triacetin, and D&C Red #30 aluminum lake.

Disithrom for oral suspension is supplied in bottles containing azithromycin dihydrate powder equivalent to 300 mg, 600 mg, 900 mg, or 1200 mg azithromycin per bottle and the following inactive ingredients: sucrose; sodium phosphate, tribasic, anhydrous; hydroxypropyl cellulose; xanthan gum; FD&C Red #40; and spray dried artificial cherry, creme de vanilla, and banana flavors. After constitution, each 5 mL of suspension contains 100 mg or 200 mg of azithromycin.

Dosage

Dosage of Disithrom is setted individually according to nosology, disease severity and sensitivity of the pathogen. Dosage for adults for oral administration is 0.25-1 g 1 time/day; for children - 5-10 mg/kg 1 time/day. The duration of administration is 2-5 days.

Overdose

If you take an overdose of Disithrom you should visit your doctor or health care provider immediately. Symptoms of Disithrom overdosage include discomfort in the stomach, diarrhea, retching and nausea.

Storage

Store Disithrom below 86 degrees F (30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Disithrom out of the reach of children and away from pets.

Side effects

The most common side effects associated with Disithrom are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take antacids that contain aluminum or magnesium within 2 hours before or after you take azithromycin. This includes Acid Gone, Aldroxicon, Alternagel, Di-Gel, Gaviscon, Gelusil, Genaton, Maalox, Maldroxal, Milk of Magnesia, Mintox, Mylagen, Mylanta, Pepcid Complete, Rolaids, Rulox, and others. These antacids can make azithromycin less effective when taken at the same time.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking azithromycin and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Avoid exposure to sunlight or tanning beds. Disithrom can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

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