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Diazole (Metronidazole)

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Diazole is an antibiotic and antiprotozoal medication. It is used either alone or with other antibiotics to treat pelvic inflammatory disease, endocarditis, and bacterial vaginosis. It is effective for dracunculiasis, giardiasis, trichomoniasis, and amebiasis.

Other names for this medication:
Acuzole, Aminidazole, Amotrex, Amrizole, Anabact, Anaeromet, Anazol, Bemetrazole, Birodogyl, Cresac, Deprocid, Diazole, Dirozyl, Dumozol, Etron, Etronil, Fladystin, Flagolin, Florazole, Geloderm, Giardyl, Imizine, Menilet, Metazole, Metrobac, Metrofusin, Metrogel, Metrolyl, Metronid, Metropast, Metroson, Metryl, Minegyl, Mtronidazole, Negazole, Nidazol, Novazole, Otrozol, Padet, Polibiotic, Protogyl, Rhodogil, Rosiced, Rozex, Trichomonacid, Trichozole, Tricodazol, Trikozol, Vertisal, Zyomet

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Also known as: Metronidazole


Diazole (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Diazole is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.


In the Female. One-day treatment – two grams of Diazole, given either as a single dose or in two divided doses of one gram each, given in the same day. Seven-day course of treatment – 250 mg three times daily for seven consecutive days. There is some indication from controlled comparative studies that cure rates as determined by vaginal smears and signs and symptoms, may be higher after a seven-day course of treatment than after a one-day treatment regimen.

The dosage regimen should be individualized. Single-dose treatment can assure compliance, especially if administered under supervision, in those patients who cannot be relied on to continue the seven-day regimen. A seven-day course of treatment may minimize reinfection by protecting the patient long enough for the sexual contacts to obtain appropriate treatment. Further, some patients may tolerate one treatment regimen better than the other.

Pregnant patients should not be treated during the first trimester In pregnant patients for whom alternative treatment has been inadequate, the one-day course of therapy should not be used, as it results in higher serum levels which can reach the fetal circulation.

When repeat courses of the drug are required, it is recommended that an interval of four to six weeks elapse between courses and that the presence of the trichomonad be reconfirmed by appropriate laboratory measures. Total and differential leukocyte counts should be made before and after re-treatment.


In cases of overdose in adults, the clinical symptoms are usually limited to nausea, vomiting, ataxia and slight disorientation. In a preterm newborn, no clinical or biological sign of toxicity developed.

There is no specific treatment for Diazole overdose, Diazole infusion should be discontinued. Patients should be treated symptomatically.


Store at room temperature below 25 degrees C (77 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Diazole are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


As a rule, the usual duration of therapy with i.v Metronidazole or other imidazole derivatives is usually less than 10 days. This period may only be exceeded in individual cases after a very strict benefit-risk assessment. Only in the rarest possible case should the treatment be repeated. Limiting the duration of treatment is necessary because damage to human germ cells cannot be excluded.

Intensive or prolonged Metronidazole therapy should be conducted only under conditions of close surveillance for clinical and biological effects and under specialist direction. If prolonged therapy is required, the physician should bear in mind the possibility of peripheral neuropathy or leucopenia. Both effects are usually reversible.

In case of prolonged treatment, occurrence of undesirable effects such as paraesthesia, ataxia, dizziness and convulsive crises should be checked. High dose regimes have been associated with transient epileptiform seizures.

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Prostaglandin E(2) (PGE(2)) induced marked and transient accumulation of c-fos mRNA, but induction of the c-fos gene occurred independent of PGE(2)-stimulated adenylate cyclase activity. OBJECTIVE: The aim of the present work was to develop a rapid, specific and highly sensitive diagnostic method for the detection of Shigella sonnei directly from stool samples. Clinical chemists and clinicians should be aware of this phenomenon and possibly repeat the analysis with a different technique. In addition, another important chloroplast division related protein, NtMinE, was cloned from the cDNA of Nicotiana tabacum. Clinical and Neurobiological Perspectives of Empowering Pediatric Cancer Patients Using Videogames. Phylogenetic analysis suggests that RNase 7 is the closest relative of RNase 8 and that the pair likely resulted from a recent gene duplication event in primates. Using this revised scale, we found that EMR female students had significantly higher neuroticism scores than did EMR male students, whereas their extraversion scores were comparable.

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Plasmodium falciparum BAEBL binds to heparan sulfate proteoglycans on the human erythrocyte surface. The objective of this study is to evaluate clinically the metabolic and hormonal effects of ibuprofen which is cyclo-oxygenase inhibitor on surgical stress. These monoclonal antibodies were previously classified as Ab1 (anti-GAT-like) and Ab3 (anti-anti-idiotype) on the basis of expression of the public idiotypic specificity (p.GAT) studied with a xenogeneic serum, anti-GAT activity, and expression of various public idiotopes. Such events may in part determine the domain of RNA secies synthesized at successive developmental stages. PPARgamma regulates trophoblast proliferation and promotes labyrinthine trilineage differentiation. Seizure prediction for epilepsy using a multi-stage phase synchrony based system. Sulforaphane (SFN), an isothiocyanate isolated from cruciferous vegetables, possesses anti-oxidant and anti-cancer bioactivities. Regional disparities in accessibility of inpatient treatment for elderly patients. Immunization of CB.20 mice with 10 micrograms PS and 100 micrograms vinblastine results in the appearance of T cells which suppress in vitro bactericidal activity of BALB/c T cells. Pronounced inflammatory reaction was observed on day 3 which attenuated on day 14 in case of titanium nickelide and on day 30-60 in case of polypropylene and caprone.

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Synthesis and distribution of H-2 antigens in preimplantation mouse embryos. This suggests that differences seen between SHRs and WKYs probably represent genetic differences between these strains and are not directly caused by the hypertension. The changes in mitochondrial membrane potential were largely dependent on the presence of external calcium. Analyses recovered six well supported matrilines that involved L. High total WBC, neutrophil, and monocyte counts were each associated with higher AF risk while lymphocyte count was inversely associated with AF risk. Permethrinic acid, 3-phenoxybenzyle chloride, alcohol, aldehyde and acid were identified in both cases, as well as 3-phenoxybenzyl cyanide from beta-cypermethrin. To examine the health related quality of life of persons with one or more self reported musculoskeletal diseases, as measured by the short form 36 item health status survey (SF-36) and the Euroqol questionnaire (EQ-5D). In agreement with this, overexpressed Spc29p was found to be a nuclear protein, whereas Spc42p is cytoplasmic. Amiloride inhibition was voltage-dependent, suggesting block within the pore, whereas stimulation was not, suggesting binding to an extracellular site.

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These cycle-related patterns of PRLR expression suggest dynamic regulation of PRLR by prolactin, thereby modulating hormonal responsiveness of seasonally growing hair follicles. The photocycle involves the reversible formation of a covalent adduct between FMN and a conserved cysteine. We now report that EAE effector T cells produce IFN-gamma when cultured in vitro with MBP. This paper is aimed towards those devices which interact with tissue and are rooted in the tenets of science. Men with angina pectoris and eczema were less satisfied with life compared with men without these diagnoses, whereas women with peptic ulcer were less satisfied with life compared with women without this diagnosis.

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Data from a longitudinal cohort study of 2,428 women who completed questionnaires in early pregnancy, at 2 months, and at 1 year after birth were analyzed. Trends in sex specific mortality from six conditions (hip fracture, septicemia, pneumonia, cancer, heart disease, and stroke) were examined for the period 1968 to 1980 to determine if recent increases in life expectancy at advanced ages were associated with significant shifts in the pattern of cause specific mortality at those ages. The resulting shuttle vector, designated pKK2O2, harboured resistance genes for chloramphenicol and tetracycline. cleocin drug interaction Preincubation of APCs with p71-90 and a mutant form of CTLA4Ig that binds only B7-1 also protected animals from developing EAE. Histology of liver sections also revealed that the extracts protected liver from injury. Although only a few infants progressed to ROP stages 4 and 5, the findings of this study indicate a potential for improvement in the treatment routines, both regarding the timing and number of laser spots at the first treatment. Insecticide resistance in the cat flea (Siphonaptera: Pulicidae). Both compounds were measured in breast milk from parturients who received the drug for postpartum pain relief.

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From 69 facilities meeting inclusion criteria, we identified 27,994 patients with colonoscopy appointments scheduled for follow-up, on the basis of positive fecal occult blood test results, between August 16, 2009 and September 30, 2011. Transient complete atrioventricular block provoked by ventricular pacing in a patient with nonsustained ventricular tachycardia. Multiple logistic regression was performed to analyze the relationships between disassortative patterns with risky sexual behaviour and drug-using practices. Cardiac resynchronization therapy is effective even in elderly patients with comorbidities. Conjugated linoleic acid (CLA) is a group of positional and geometric isomers of conjugated dienoic derivatives of linoleic acid. Octopamine reduces potassium permeability of the glia that form the insect blood-brain barrier. In addition, diacylglycerol, a physiological PKC agonist, induced a significant increase in hMSH2 expression, whereas chelerythrine or calphostin C, two PKC inhibitors, significantly decreased TPA-induced hMSH2 expression.

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2 cases of recurrence of rickettsial disease with vascular localization. Even though laterality was confirmed in both grip and elbow flexion, gender difference is more marked in hand grip. Still, only ECSWT and LLLT have been meta-analytically researched. DAS181, a sialidase fusion protein, protects human airway epithelium against influenza virus infection: an in vitro pharmacodynamic analysis. Closely related species demonstrated single bands of various sizes and were easily distinguished from enterococci.

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Trafficking, assembly, and function of a connexin43-green fluorescent protein chimera in live mammalian cells. Eukaryotic genomes are packaged into chromatin, a compact structure containing fundamental repeating units, the nucleosomes. A second inhibitor, compound 12, has an IC(50) value of 240nM against the Yersinia PTPase. The aim of this study was to introduce a new technique which is combined laparoscopic and vaginal cervicovaginal reconstruction using split thickness skin graft in patients with congenital atresia of cervix and to evaluate the feasibility and the safety of it. The authors used in vivo 31-phosphorus magnetic resonance spectroscopy to study hepatic metabolism after surgical trauma with and without loss of liver cell mass. The effect of response execution on P3 latency, reaction time, and movement time. Wild-type, but not mutant, p53val135 promoted G2/M arrest and accumulation of BAK protein in all cell lines. Total quality strategy in the formative process of the noroxin 400 mg plm occupational physician.

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When a significant segment of nucleus has dislocated during phacoemulsification surgery, vigorous irrigation or direct attempts to remove the lens fragments should be avoided. Asthma is not prevalent in Aboriginal and Torres Strait Islander children: a myth. Manifestations and treatment of caries are strongly dependent on caries risk and the severity of the attacking factors which determine the degree of caries activity. Several hypotheses have been proposed to explain how the brain tissue reaction to single unit recording electrodes influences biocompatibility including progressive changes in the spatial distribution of reactive astrocytes, and the loss of neurons over the indwelling period. The objectives of the present study were to evaluate models to predict urinary N and expected MUN, by using older and newer data sets, and to quantify changes flagyl classification of drug that may have occurred in MUN measurements over time. A prospective, open, randomized, parallel-group study with allocation either to a comprehensive multiple risk factor modification programme or to usual care. Isolation and partial characterization of a proteinase inhibitor from human colorectal adenocarcinoma.

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Pathogenesis of invasive micropapillary carcinoma: role of MUC1 glycoprotein. This suggests that platelets may play a role in the micro- and macrovascular complications of diabetic patients. The main activities required to control blindness in Poland are promotion of pregnancy and prematurity care and improvements in the early diagnosis and treatment of retinopathy of prematurity. This paper examines medical waste management, including the common sources, governing legislation and handling and disposal methods. The effect of methyl substitution at the C-5 and C-10 positions of neurosteroids on electrophysiological activity at GABAA receptors. A revision of the history of the Colletotrichum acutatum species complex in the Nordic countries based on herbarium specimens. Attitudes of Israeli Jewish and Arab high school students toward alcohol control measures. Its successful implementation is dependent on a team approach between sonographers, nurses, and physicians.

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