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Cotet (Oxytetracycline)
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Cotet

Cotet is an antibiotic used to treat a wide variety of bacterial infections. The brand name drug Cotet is no longer available in the U.S., but generic versions may still be available.

Other names for this medication:
Betacycline, Cotet, Dynoxytet, Ecomycin, Geomicina, Innolyre, Oxyteracin, Oxytetracycline, Tetracin

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Also known as: Oxytetracycline

Description

Cotet is a product of the metabolism of Streptomyces rimosus and is one of the family of Cotet antibiotics. A 1 percent solution in water is acidic (pH about 2.5). Its potency is affected in solutions more acid than pH 2 and it is rapidly destroyed by alkali hydroxides.

Cotet diffuses readily through the placenta into the fetal circulation, into the pleural fluid and, under some circumstances, into the cerebrospinal fluid. It appears to be concentrated in the hepatic system and excreted in the bile, so that it appears in the feces, as well as in the urine, in a biologically active form.

Inert ingredients in the formulation are: glucosamine hydrochloride; hard gelatin capsules (which may contain Red 3, Yellow 10 and other inert ingredients); magnesium stearate; sodium lauryl sulfate; starch.

Dosage

Take Cotet by mouth with a full glass of water on an empty stomach at least 1 hour before or 2 hours after eating. Do not lie down for 30 minutes after taking Cotet. Avoid taking milk, dairy products, calcium-enriched juices before and after consuming the drug. It is better to take Cotet every day at the same time. Cotet treats different types of bacterial infections and can be used both by adults and by children. Thus, each age has different instructions. For children above 8 years of age: the usual daily dose is 25–50 mg per kg of body weight divided into 4 equal doses. For Adults: the usual daily dose is 1–2 g divided in 4 equal doses, depending on the severity of the infection. For treatment of brucellosis, 500 mg oxytetracycline four times daily for 3 weeks should be accompanied by streptomycin, 1 gram intramuscularly twice daily the first week, and once daily the second week. For treatment of uncomplicated gonorrhea, when penicillin is contraindicated, tetracycline may be used for the treatment of both males and females in the following divided dosage schedule: 1.5 grams initially followed by 0.5 gram q.i.d. for a total of 9.0 grams. For treatment of syphilis, a total of 30–40 grams in equally divided doses over a period of 10–15 days should be given. Do not stop taking Cotet suddenly. Therapy should be continued for at least 24–48 hours after symptoms and fever have subsided.

Overdose

If you overdose Generic Tetracycline and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Cotet overdosage: retching, diarrhoea, nausea.

Storage

Store Cotet at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Keep away from heat, moisture, and light. Do not store in the bathroom. Keep Cotet out of the reach of children and away from pets.

Side effects

The most common side effects associated with Cotet are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

This drug is contraindicated in persons who have shown hypersensitivity to any of the tetracyclines.

As with other antibiotic preparations, use of this drug may result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs, the antibiotic should be discontinued and appropriate therapy instituted.

In venereal diseases when coexistent syphilis is suspected, a dark field examination should be done before treatment is started and the blood serology repeated monthly for at least 4 months.

Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.

In long term therapy, periodic laboratory evaluation of organ systems, including hematopoietic, renal and hepatic studies should be performed.

All infections due to Group A beta-hemolytic streptococci should be treated for at least 10 days.

Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline in conjunction with penicillin.

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