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Chloromycetin (Chloramphenicol)
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Chloromycetin

Chloramphenicol (brand names include: Chlornitromycin / Chloromycetin / Fenicol / Phenicol / Nevimycin / Vernacetin / Veticol) is a broad-spectrum synthetic antibiotic. Chloramphenicol is used to treat a wide variety of bacterial infections, including lung and blood infections; infections of the brain including bacterial meningitis and brain abscesses; and infections of the eye, ear or skin.

Other names for this medication:
Chloramphenicol, Chloroptic, Fenicol, Sopamycetin

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Also known as: Chloramphenicol

Description

Chloramphenicol belongs to the family of medicines called antibiotics. Chloramphenicol otic drops are used to treat infections of the ear canal. This medicine may be used alone or with other medicines that are taken by mouth for ear canal infections.

Chloramphenicol is available only with your doctor's prescription.

Dosage

Adults should receive 50 mg/kg/day in divided doses at 6-hour intervals. In exceptional cases patients with infections due to moderately resistant organisms may require increased dosage up to 100 mg/kg/day to achieve blood levels inhibiting the pathogen, but these high doses should be decreased as soon as possible. Adults with impairment of hepatic or renal function or both may have reduced ability to metabolize and excrete the drug. In instances of impaired metabolic processes, dosages should be adjusted accordingly. Precise control of concentration of the drug in the blood should be carefully followed in patients with impaired metabolic processes by the available microtechniques (information available on request).

Pediatric Patients. Dosage of 50 mg/kg/day divided into 4 doses at 6-hour intervals yields blood levels in the range effective against most susceptible organisms. Severe infections (eg, bacteremia or meningitis), especially when adequate cerebrospinal fluid concentrations are desired, may require dosage up to 100 mg/kg/day; however, it is recommended that dosage be reduced to 50 mg/kg/day as soon as possible. Children with impaired liver or kidney function may retain excessive amounts of the drug.

Neonates. A total of 25 mg/kg/day in 4 equal doses at 6-hour intervals usually produces and maintains concentrations in blood and tissues adequate to control most infections for which the drug is indicated. Increased dosage in these individuals, demanded by severe infections, should be given only to maintain the blood concentration within a therapeutically effective range. After the first two weeks of life, full-term neonates ordinarily may receive up to a total of 50 mg/kg/day equally divided into 4 doses at 6-hour intervals. These dosage recommendations are extremely important because blood concentration in all premature and full-term neonates under two weeks of age differs from that of other infants neonates. This difference is due to variations in the maturity of the metabolic functions of the liver and the kidneys. When these functions are immature (or seriously impaired in adults), high concentrations of the drug are found which tend to increase with succeeding doses.

Overdose

Overdosing by the patient is nearly impossible, as Chloromycetin is administered via IV delivery, however an overdose can still happen. The symptoms of an overdose are likely to include nausea, vomiting, mouth odor or unpleasant taste in the mouth, bone marrow suppression, and diarrhea.

Storage

Keep all medicines out of the reach and sight of children.

Chloramphenicol eye drops (including single-use units) must be kept in a fridge (2 to 8 degrees C).

Chloramphenicol eye ointment should be stored in a cool, dry place, away from direct heat and light.

Throw away the bottle or tube of chloramphenicol after you have finished the five-day course of treatment, even if there is some left. Never keep opened bottles or tubes to use later.

Single-use units should be used as soon as the unit is opened. Do not store or re-use opened units for subsequent doses. This is because the units do not contain any preservative.

Side effects

The most common side effects associated with Chloromycetin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Chloromycetin if you are allergic to Generic Chloromycetin components. Try to be careful with Generic Chloromycetin if you're pregnant or you plan to have a baby, or you are a nursing mother. Generic Chloromycetin can harm your baby. Generic Chloromycetin should not be used for colds, flu, other virus infections, sore throats or other minor infections, or to prevent infections. It can be dangerous to stop Generic Chloromycetin taking suddenly.

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