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Amoxiline (Amoxicillin)
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Amoxiline

Amoxiline may be recommended to treat infections of the nose, ears, throat, urinary tract, or skin. It can also be used for pneumonia, tonsillitis, or bronchitis. Sometimes it’s given with other medicines to get rid of H. pylori, a species of bacteria that causes ulcers.

Other names for this medication:
Aloxyn, Amoram, Amoxi, Amoxicilina, Amoxicillinum, Amoxivet, Amoxypen, Bimoxan, Cipmox, Clamoxyl, Flemoxin, Flemoxon, Galenamox, Larotid, Lupimox, Novamoxin, Ospamox, Penamox, Penimox, Polymox, Robamox, Servamox, Tolodina, Utimox, Zimox

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Also known as: Amoxicillin

Description

Amoxiline is one of the best forms of antibiotic available today. It is used to treat infections caused by certain bacteria, including: infections of the ear, nose, and throat (pneumonia, bronchitis); infections of the genitourinary tract; infections of the skin and skin structure; infections of the lower respiratory tract; gonorrhea, acute uncomplicated (ano-genital and urethral infections) in male and females.

Amoxiline is also used before some surgery or dental work to prevent infection. It is also used in combination with other medications to eliminate H. pylori, a bacteria that causes ulcers. Amoxiline may also be used for other purposes not listed here.

Amoxiline acts by inhibiting the synthesis of bacterial cell wall and stopping the growth of bacteria.

Amoxiline is available in capsules.

Amoxiline is usually taken every 8 hours (three times a day). It can be taken with or without food.

The chewable tablets should be crushed or chewed thoroughly before they are swallowed. The tablets and capsules should be swallowed whole and taken with a full glass of water.

Take Amoxiline exactly as directed. Do not take more or less Amoxiline or take it more often than prescribed by your doctor. Do not stop taking Amoxiline without talking to your doctor. To clear up your infection completely, continue taking Amoxiline for the full course of treatment even if you feel better in a few days. Stopping Amoxiline too soon may cause bacteria to become resistant to antibiotics.

Dosage

Adults: 1 g PO once daily or 500 mg PO twice daily for 10 days. The American Heart Association (AHA) recommends extended-release Amoxiline as an alternative to penicillin V for rheumatic fever prophylaxis.

Infants, Children, and Adolescents: 25 mg/kg/dose (Max: 500 mg/dose) PO twice daily for 10 days is recommended by the Infectious Diseases Society of America (IDSA). Alternatively, 50 mg/kg/dose PO once daily (Max: 1 g/dose) for 10 days is recommended by The American Heart Association (AHA) as an alternative to penicillin V. For ear/nose/throat infections in general, the FDA-approved dosage is 20 mg/kg/day PO in divided doses every 8 hours (Max: 250 mg/dose) or 25 mg/kg/day PO in divided doses every 12 hours (Max: 500 mg/dose) for mild to moderate infections and 40 mg/kg/day PO in divided doses every 8 hours (Max: 500 mg/dose) or 45 mg/kg/day PO in divided doses every 12 hours (Max: 875 mg/dose) for severe infections.

Overdose

In case of overdosage, discontinue medication, treat symptomatically, and institute supportive measures as required. If the overdosage is very recent and there is no contraindication, an attempt at emesis or other means of removal of drug from the stomach may be performed. A prospective study of 51 pediatric patients at a poison-control center suggested that overdosages of less than 250 mg/kg of Amoxiline are not associated with significant clinical symptoms and do not require gastric emptying.

Interstitial nephritis resulting in oliguric renal failure has been reported in a small number of patients after overdosage with Amoxiline.

Crystalluria, in some cases leading to renal failure, has also been reported after Amoxiline overdosage in adult and pediatric patients. In case of overdosage, adequate fluid intake and diuresis should be maintained to reduce the risk of Amoxiline crystalluria.

Renal impairment appears to be reversible with cessation of drug administration. High blood levels may occur more readily in patients with impaired renal function because of decreased renal clearance of Amoxiline. Amoxiline may be removed from circulation by hemodialysis.

Storage

Generic: store at controlled room temperature (between 68 and 77 degrees F)

Amoxil: store at controlled room temperature (between 68 and 77 degrees F)

Moxatag: store at 77 degrees F; excursions permitted to 59-86 degrees F

Moxilin: store at controlled room temperature (between 68 and 77 degrees F)

Sumox: store at controlled room temperature (between 68 and 77 degrees F)

Trimox: store at controlled room temperature (between 68 and 77 degrees F)

Side effects

The most common side effects associated with Amoxiline are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Colitis, diarrhea, GI disease, inflammatory bowel disease, pseudomembranous colitis, ulcerative colitis.

Almost all antibacterial agents have been associated with pseudomembranous colitis (antibiotic-associated colitis) which may range in severity from mild to life-threatening. In the colon, overgrowth of Clostridia may exist when normal flora is altered subsequent to antibacterial administration. The toxin produced by Clostridium difficile is a primary cause of pseudomembranous colitis. It is known that systemic use of antibiotics predisposes patients to development of pseudomembranous colitis. Consideration should be given to the diagnosis of pseudomembranous colitis in patients presenting with diarrhea following antibacterial administration. Systemic antibiotics should be prescribed with caution to patients with inflammatory bowel disease such as ulcerative colitis or other GI disease. If diarrhea develops during therapy, the drug should be discontinued. Following diagnosis of pseudomembranous colitis, therapeutic measures should be instituted. In milder cases, the colitis may respond to discontinuation of the offending agent. In moderate to severe cases, fluids and electrolytes, protein supplementation, and treatment with an antibacterial effective against Clostridium difficile may be warranted. Products inhibiting peristalsis are contraindicated in this clinical situation. Practitioners should be aware that antibiotic-associated colitis has been observed to occur over two months or more following discontinuation of systemic antibiotic therapy; a careful medical history should be taken.

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