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Acquire (Levofloxacin)
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Acquire

Acquire is an antibiotic that is used to treat bacterial infections resulting in pneumonia (Fluid build up in the lungs), urinary tract infection, bladder infection, prostate gland infection as well as skin infections.

Other names for this medication:
Acquire, Benfloxin, Cravit, Cravox, Difloxin, Evonex, Floxlevo, Ledric, Lefex, Leflokin, Levocine, Levoday, Levof, Levoflox, Levofloxacin, Levofloxacina, Levofloxacinum, Levomac, Levonix, Levoproxol, Levoquinol, Levores, Levovid, Levox, Levoxa, Levoxal, Levoxetina, Levoxin, Lovicin, Loxof, Nivoloc, Oftaquix, Orlev, Prixar, Septibiotic, Tamiram, Ultraquin, Voflaxin, Volequin, Xenoxin

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Terramycin, Rulide, Chloromycetin, Ceftin, Duricef, Ilosone

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Also known as: Levofloxacin

Description

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Acquire and other antibacterial drugs, Acquire should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Acquire Tablets/Injection and Oral Solution are indicated for the treatment of adults (≥18 years of age) with mild, moderate, and severe infections caused by susceptible strains of the designated microorganisms in the conditions listed in this section. Acquire Injection is indicated when intravenous administration offers a route of administration advantageous to the patient (e.g., patient cannot tolerate an oral dosage form).

Dosage

Rapid or bolus intravenous infusion of Acquire has been associated with hypotension and must be avoided. Acquire Injection should be infused intravenously slowly over a period of not less than 60 or 90 minutes, depending on the dosage. Acquire Injection should be administered only by intravenous infusion. It is not for intramuscular, intrathecal, intraperitoneal, or subcutaneous administration.

Overdose

Overdose of the drug should be strictly avoided and if anyone has accidentally taken the overdose of the drug, then the victim should be provided with emergency medical help. Overdose victim can also consult to their local poison helpline. Some of the overdose symptoms include loss of coordination, drooping eyelids, weakness, decreased activity, trouble breathing, sweating, tremors, or seizure.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep in a tightly closed container. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Acquire are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Risk of tendinitis and tendon rupture is increased. This risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroids, and in patients with kidney, heart and lung transplants. Discontinue if pain or inflammation in a tendon occurs.

Anaphylactic reactions and allergic skin reactions, serious, occasionally fatal, may occur after first dose.

Hematologic (including agranulocytosis, thrombocytopenia), and renal toxicities may occur after multiple doses.

Hepatotoxicity: Severe, and sometimes fatal, hepatoxicity has been reported. Discontinue immediately if signs and symptoms of hepatitis occur.

Central nervous system effects, including convulsions, anxiety, confusion, depression, and insomnia may occur after the first dose. Use with caution in patients with known or suspected disorders that may predispose them to seizures or lower the seizure threshold.

Clostridium difficile-associated colitis: evaluate if diarrhea occurs.

Peripheral neuropathy: discontinue if symptoms occur in order to prevent irreversibility.

Prolongation of the QT interval and isolated cases of torsade de pointes have been reported. Avoid use in patients with known prolongation, those with hypokalemia, and with other drugs that prolong the QT interval.

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In addition, differentiation into neuron-like cells expressing markers typical for mature neurons has been reported. Rapid serologic diagnosis of dengue virus infection using a commercial capture ELISA that distinguishes primary and secondary infections. The effects of SKF 38393 (D1-agonist) and SCH 23390 (D1-antagonist) were compared with those of haloperidol (D2 greater than D1-antagonist) and metoclopramide (D2-antagonist) in the absence or presence of apomorphine (D1/D2-agonist) and RU 24213 (D2 agonist) in non-habituated mice. Irritable bowel syndrome is extremely common and its severity is widely underestimated. Evaluation of the Roche Amplicor polymerase chain reaction assay for detection of enteroviruses in cerebrospinal fluid and its potential impact on patient management. We have previously reported that serum TARC levels correlate with the severity of AD. The recurrence of dysuria, after the intervention, has always been caused by an additional lower urinary tract pathology. This might lead to the incomplete phagocytosis of apoptotic PMNs by Mphis. Inhalation of antigen in immunized mice induces an infiltration of eosinophils into the airways and increased bronchial hyperreactivity as are observed in human asthma.

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In 2012, the first Nigerian Hepatitis B Virus (HBV) immune escape mutant (IEM) case was detected in a pregnant woman in southwestern Nigeria. Application of pharmacoeconomics to formulary decision making in managed care organizations. During the first 3 months of life, bone mineral density was reduced, whereas percent body fat was increased in transgenic animals compared with wild-type littermates, with associated decreased bone formation rate and osteoblast number, but normal osteoclast number. An attempt has been made to apply the analytical process to the context of health visiting. Identification, mapping, and genomic structural analysis of an immunoreceptor tyrosine-based inhibition motif-bearing C-type lectin from homozygous clones of rainbow trout (Oncorhynchus mykiss). Here, we show that K1-5 bound to endothelial cell surface ATP synthase and triggered caspase-mediated endothelial cell apoptosis. The path analysis revealed that the genes pobA and pytH had the greatest direct effects on the degradation of beta-cypermethrin (pobA), alpha-cypermethrin (pobA), theta-cypermethrin (pytH) and 3-phenoxybenzoic acid (pytH). We systemically reviewed published studies (January 2007 to September 2013) from full-text databases such as VIP, Chinese National Knowledge Infrastructure, and PubMed and assessed HBsAg-positive rates using a random effects regression model with comprehensive meta-analysis software.

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Surgery for patients with central protruded lumbar discs who have failed conservative therapy. Alpha-tocopherol, ascorbate, catalase, and NAC can inhibit MEP-induced genotoxicity, indicating that ROS might be involved in this effect. Achieving positive changes in behavior related to pain management requires a well-developed plan that incorporates model-based instruction in both cognitive and affective domains. An indirect solid phase radioimmunoassay using rabbit antibodies to the synthetic double-stranded RNA poly rI-rC and 125I-labelled sheep anti-rabbit IgG could detect 1 ng of poly rI-rC. We report the pre-operative preparation and anaesthetic management for resection of an intracerebral tumour during awake craniotomy in a 9-year-old boy.

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Urinary Bladder Paraganglioma: AIRP Best Cases in Radiologic-Pathologic Correlation. These recent developments provide new insights into the functions of this enigmatic receptor. These results are flagyl yeast infection medicine particularly relevant in the light of the recent report that the urokinase-type plasminogen activator receptor, a protein that also binds VN, has been shown to associate with the cation-independent mannose-6-phosphate/IGF-II receptor and suggest a possible role for IGF-II in cell adhesion and invasion. Identification of miRNAs in Bovine Endometrium through RNAseq and Prediction of Regulated Pathways. Twenty-one derived components of the CO2 expirogram were evaluated as predictors of cardiac output. In this report, the structures of the detyrosinated carboxy-terminal peptides of alpha-tubulin from newborn and adult mouse brain were compared. in the absence of dystonia, the expression of Fos-ir did not reveal any differences between dtsz hamsters and controls. Human skin is the first defense barrier against the external environment, especially microbial pathogens and physical stimulation. This is the first report of the CRY-DASH members from vertebrates and fungi. Clinical significance of hemostatic molecular markers in acute leukemia.

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