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Abbotic (Clarithromycin)
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Abbotic

Abbotic is used for the treatment of various infections in the body like infections of the throat, sinus, skin, soft tissue, chest (infection of lungs and windpipe). It is also used in the treatment of ulcers in the intestine caused by bacteria known as helicobacter pylori. It is also used for pneumonia as well as for skin infections.

Other names for this medication:
Biclar, Bicrolid, Ciclinil, Cidoclar, Clabact, Clacee, Clacina, Claritab, Clarithromycin, Clariwin, Clarogen, Claron, Claryl, Claxid, Clormicin, Derizic, Emimycin, Glartin, Helozym, Kalixocin, Klariger, Klarimac, Klarithrin, Klazidem, Klonacid, Larizin, Laromin, Maclar, Macrobid, Onexid, Rocin, Rodizim, Rolicytin, Synclar, Taclar, Veclam, Zeclar

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Also known as: Clarithromycin

Description

Abbotic (generic name: clarithromycin; brand names include: Maclar / Klaricid / Klacid / Clarimac / Claribid) is used to treat many different types of bacterial infections affecting the skin and respiratory system, including: Strep throat, Pneumonia, Sinusitis (inflamed sinuses), Tonsillitis (inflamed tonsils), Acute middle ear infections, Acute flare-ups of chronic bronchitis.

It also is used to treat and prevent disseminated Mycobacterium avium complex (MAC) infection [a type of lung infection that often affects people with human immunodeficiency virus (HIV)]. It is used in combination with other medications to eliminate H. pylori, a bacteria that causes ulcers.

It also is used sometimes to treat other types of infections including Lyme disease (an infection that may develop after a person is bitten by a tick), crypotosporidiosis (an infection that causes diarrhea), cat scratch disease (an infection that may develop after a person is bitten or scratched by a cat), Legionnaires' disease (a type of lung infection), and pertussis (whooping cough; a serious infection that can cause severe coughing). It is also sometimes used to prevent heart infection in patients having dental or other procedures.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Abbotic works by stopping the growth of or killing sensitive bacteria by interfering with their protein synthesis.

Dosage

The recommended daily dosage is 15 mg/kg/day divided every 12 hours for 10 days (up to the adult dose). Refer to dosage regimens for mycobacterial infections in pediatric patients for additional dosage information.

For the treatment of disseminated infection due to Mycobacterium avium complex (MAC), Abbotic Filmtab and Abbotic Granules are recommended as the primary agents. Abbotic Filmtab and Abbotic Granules should be used in combination with other antimycobacterial drugs (e.g. ethambutol) that have shown in vitro activity against MAC or clinical benefit in MAC treatment.

For treatment and prophylaxis of mycobacterial infections in adults, the recommended dose of Abbotic is 500 mg every 12 hours.

For treatment and prophylaxis of mycobacterial infections in pediatric patients, the recommended dose is 7.5 mg/kg every 12 hours up to 500 mg every 12 hours.

Abbotic therapy should continue if clinical response is observed. Abbotic can be discontinued when the patient is considered at low risk of disseminated infection.

Overdose

Overdose symptoms may include severe stomach pain, nausea, vomiting, or diarrhea.

Storage

Store Abbotic at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Abbotic out of the reach of children and away from pets.

Side effects

The most common side effects associated with Abbotic are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Concomitant cisapride, pimozide, ergots, HMG-CoA reductase inhibitors extensively metabolized by CYP3A4 (lovastatin or simvastatin). History of QT prolongation or ventricular cardiac arrhythmia (including torsades de pointes). Concomitant colchicine (in renal or hepatic impairment). Cholestatic jaundice/hepatic dysfunction with prior clarithromycin use.

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Optical coherence tomography scans of human eyes were obtained in vivo during femtosecond laser-assisted cataract surgery. Endothelin-1 inhibits endothelium-dependent vasodilatation in the human forearm: reversal by ETA receptor blockade in patients with atherosclerosis. A small circular TAR RNA decoy specifically inhibits Tat-activated HIV-1 transcription. The analysis with Ad12 mutants showed that Ad12 E1B products, especially the 19K protein, were important for the expression of the endogenous beta interferon gene and Ad12 E1A products were not involved in the expression. Nevertheless, because the proteins are probably indirectly involved in ageing and cancer, we assess their possible role in these processes. Magnetofection provides a novel tool for high throughput gene screening in vitro and can help to overcome fundamental limitations to gene therapy in vivo.

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